The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lta4h  -  leukotriene A4 hydrolase

Mus musculus

Synonyms: LTA-4 hydrolase, LTA4 hydrodase, Leukotriene A(4) hydrolase, Leukotriene A-4 hydrolase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lta4h


High impact information on Lta4h


Chemical compound and disease context of Lta4h


Biological context of Lta4h


Anatomical context of Lta4h


Associations of Lta4h with chemical compounds

  • Surprisingly, this change in localization of LTA4 hydrolase did not affect the capacity of isolated cells to convert LTA4 to LTB4 [2].
  • In the AOM-treated mice not receiving green tea, the high-fat diet significantly enhanced colonic levels of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene B4, but it did not significantly alter prostaglandin E2 levels and aberrant crypt foci formation [11].
  • Leukotriene-A4 hydrolase (EC cleaved the NH2-terminal amino acid from several tripeptides, typified by arginyl-glycyl-aspartic acid, arginyl-glycyl-glycine, and arginyl-histidyl-phenylalanine, with catalytic efficiencies (kcat/Km) > or = 1 x 10(6) M-1 s-1 [12].
  • From sequence comparisons with aminopeptidases, a tyrosine at position 383 in LTA4 hydrolase has been suggested as a possible catalytic amino acid [13].

Other interactions of Lta4h


Analytical, diagnostic and therapeutic context of Lta4h


  1. Recombinant mouse leukotriene A4 hydrolase: a zinc metalloenzyme with dual enzymatic activities. Wetterholm, A., Medina, J.F., Rådmark, O., Shapiro, R., Haeggström, J.Z., Vallee, B.L., Samuelsson, B. Biochim. Biophys. Acta (1991) [Pubmed]
  2. Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung. Brock, T.G., Lee, Y.J., Maydanski, E., Marburger, T.L., Luo, M., Paine, R., Peters-Golden, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  3. The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. Menard, A., Papini, E., Mock, M., Montecucco, C. Biochem. J. (1996) [Pubmed]
  4. Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis. Tsuji, F., Miyake, Y., Enomoto, H., Horiuchi, M., Mita, S. Eur. J. Pharmacol. (1998) [Pubmed]
  5. Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase. Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rådmark, O., Samuelsson, B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. Byrum, R.S., Goulet, J.L., Snouwaert, J.N., Griffiths, R.J., Koller, B.H. J. Immunol. (1999) [Pubmed]
  7. Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid. Implications for the epoxide hydrolase mechanism. Andberg, M.B., Hamberg, M., Haeggström, J.Z. J. Biol. Chem. (1997) [Pubmed]
  8. Effect of azelastine on leukotriene synthesis in murine peritoneal cells and on thromboxane synthesis in human platelets. Nishihira, J., Hayakawa, T., Suzuki, K., Kato, K., Ishibashi, T. Int. Arch. Allergy Appl. Immunol. (1989) [Pubmed]
  9. Amino-acid sequence and tissue distribution of guinea-pig leukotriene A4 hydrolase. Minami, M., Mutoh, H., Ohishi, N., Honda, Z., Bito, H., Shimizu, T. Gene (1995) [Pubmed]
  10. Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase. Haeggström, J., Meijer, J., Rådmark, O. J. Biol. Chem. (1986) [Pubmed]
  11. Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model. Ju, J., Liu, Y., Hong, J., Huang, M.T., Conney, A.H., Yang, C.S. Nutrition and cancer. (2003) [Pubmed]
  12. The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity. Orning, L., Gierse, J.K., Fitzpatrick, F.A. J. Biol. Chem. (1994) [Pubmed]
  13. Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase. Blomster, M., Wetterholm, A., Mueller, M.J., Haeggström, J.Z. Eur. J. Biochem. (1995) [Pubmed]
  14. Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system. Chiba, Y., Shimada, A., Satoh, M., Saitoh, Y., Kawamura, N., Hanai, A., Keino, H., Ide, Y., Shimizu, T., Hosokawa, M. Neuroscience (2006) [Pubmed]
  15. Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis. Medina, J.F., Wetterholm, A., Rådmark, O., Shapiro, R., Haeggström, J.Z., Vallee, B.L., Samuelsson, B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  16. Molecular cloning and expression of mouse leukotriene A4 hydrolase cDNA. Medina, J.F., Rådmark, O., Funk, C.D., Haeggström, J.Z. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
WikiGenes - Universities