Gene Review:
Lta4h - leukotriene A4 hydrolase
Mus musculus
Synonyms:
LTA-4 hydrolase, LTA4 hydrodase, Leukotriene A(4) hydrolase, Leukotriene A-4 hydrolase
- Recombinant mouse leukotriene A4 hydrolase: a zinc metalloenzyme with dual enzymatic activities. Wetterholm, A., Medina, J.F., Rådmark, O., Shapiro, R., Haeggström, J.Z., Vallee, B.L., Samuelsson, B. Biochim. Biophys. Acta (1991)
- Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung. Brock, T.G., Lee, Y.J., Maydanski, E., Marburger, T.L., Luo, M., Paine, R., Peters-Golden, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. Menard, A., Papini, E., Mock, M., Montecucco, C. Biochem. J. (1996)
- Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis. Tsuji, F., Miyake, Y., Enomoto, H., Horiuchi, M., Mita, S. Eur. J. Pharmacol. (1998)
- Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase. Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rådmark, O., Samuelsson, B. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. Byrum, R.S., Goulet, J.L., Snouwaert, J.N., Griffiths, R.J., Koller, B.H. J. Immunol. (1999)
- Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid. Implications for the epoxide hydrolase mechanism. Andberg, M.B., Hamberg, M., Haeggström, J.Z. J. Biol. Chem. (1997)
- Effect of azelastine on leukotriene synthesis in murine peritoneal cells and on thromboxane synthesis in human platelets. Nishihira, J., Hayakawa, T., Suzuki, K., Kato, K., Ishibashi, T. Int. Arch. Allergy Appl. Immunol. (1989)
- Amino-acid sequence and tissue distribution of guinea-pig leukotriene A4 hydrolase. Minami, M., Mutoh, H., Ohishi, N., Honda, Z., Bito, H., Shimizu, T. Gene (1995)
- Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase. Haeggström, J., Meijer, J., Rådmark, O. J. Biol. Chem. (1986)
- Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model. Ju, J., Liu, Y., Hong, J., Huang, M.T., Conney, A.H., Yang, C.S. Nutrition and cancer. (2003)
- The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity. Orning, L., Gierse, J.K., Fitzpatrick, F.A. J. Biol. Chem. (1994)
- Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase. Blomster, M., Wetterholm, A., Mueller, M.J., Haeggström, J.Z. Eur. J. Biochem. (1995)
- Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system. Chiba, Y., Shimada, A., Satoh, M., Saitoh, Y., Kawamura, N., Hanai, A., Keino, H., Ide, Y., Shimizu, T., Hosokawa, M. Neuroscience (2006)
- Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis. Medina, J.F., Wetterholm, A., Rådmark, O., Shapiro, R., Haeggström, J.Z., Vallee, B.L., Samuelsson, B. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Molecular cloning and expression of mouse leukotriene A4 hydrolase cDNA. Medina, J.F., Rådmark, O., Funk, C.D., Haeggström, J.Z. Biochem. Biophys. Res. Commun. (1991)