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Gene Review

Dsp  -  desmoplakin

Rattus norvegicus

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Disease relevance of Dsp


High impact information on Dsp

  • Redistribution of adducin after addition of extracellular Ca++ is independent of formation of desmosomal and adherens junctions since assembly of adducin at contact sites requires lower concentrations of Ca++ and occurs more rapidly than redistribution of desmoplakin or vinculin [2].
  • It is shown that the desmoplakin-containing structures are often associated with IF stained by antibodies to desmin, i.e., the characteristic type of IF present in these cells [3].
  • Connexin43, desmoplakin, and cadherin were localized between grafted cardiomyocytes themselves and between grafted and host cardiomyocytes [4].
  • In addition, we show that the sequence requirements for the recruitment of desmoplakin, another desmosomal plaque protein, differ and that a short (10 aa) segment of the desmocollin 1a tail, located close to the plasma membrane, is also required for the binding of plakoglobin, as well as of desmoplakin, and also for IF anchorage [5].
  • Immunostaining for connexin 43 (Cx43) and for cell adhesion junction proteins (N-cadherin, catenins, and desmoplakin) in single- and double-label techniques was analyzed and quantified by confocal and electron microscopy [6].

Biological context of Dsp


Anatomical context of Dsp

  • These observations show that anchorage at desmosomal plaques is not restricted to IF of the cytokeratin type and that IF composed of either cytokeratin or desmin, specifically attach, in a lateral fashion, to desmoplakin-containing regions of the plasma membrane [3].
  • The newly formed ID, observed after 5 days, showed the presence of N-cadherin, catenins, and desmoplakin, low levels of Cx43, and absence of ultrastructurally discernible gap junctions [6].
  • To examine this question, we have used immunoelectron and immunoconfocal microscopy to analyze the spatial distributions of gap junctional (connexin43), desmosomal (desmoplakin), and adherens junctional (N-cadherin) components during maturation of rodent and canine left ventricular myocardium [10].
  • Confocal microscopy revealed that the first visible effect of microcystin-LR is disruption of desmoplakin organization at the cell surface, indicating dissociation of desmosomes [7].
  • Rhodamine phalloidin was used to monitor the organizational state of the myofibrils and antibodies to desmoplakin and vinculin were used as markers for the presence of desmosomes and fasciae adherentes, respectively [11].

Other interactions of Dsp


Analytical, diagnostic and therapeutic context of Dsp

  • After treatment with NiCl2 (150 micrograms/ml) for 24 hr, the cytokeratin filaments and desmoplakin became focally detached from the cell cortex and retracted to form an aggregate around the nucleus [15].


  1. Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts. Matsushita, T., Oyamada, M., Fujimoto, K., Yasuda, Y., Masuda, S., Wada, Y., Oka, T., Takamatsu, T. Circ. Res. (1999) [Pubmed]
  2. Adducin: Ca++-dependent association with sites of cell-cell contact. Kaiser, H.W., O'Keefe, E., Bennett, V. J. Cell Biol. (1989) [Pubmed]
  3. Specific attachment of desmin filaments to desmosomal plaques in cardiac myocytes. Kartenbeck, J., Franke, W.W., Moser, J.G., Stoffels, U. EMBO J. (1983) [Pubmed]
  4. Formation of cell junctions between grafted and host cardiomyocytes at the border zone of rat myocardial infarction. Matsushita, T., Oyamada, M., Kurata, H., Masuda, S., Takahashi, A., Emmoto, T., Shiraishi, I., Wada, Y., Oka, T., Takamatsu, T. Circulation (1999) [Pubmed]
  5. Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation. Troyanovsky, S.M., Troyanovsky, R.B., Eshkind, L.G., Leube, R.E., Franke, W.W. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Kostin, S., Hein, S., Bauer, E.P., Schaper, J. Circ. Res. (1999) [Pubmed]
  7. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. Toivola, D.M., Goldman, R.D., Garrod, D.R., Eriksson, J.E. J. Cell. Sci. (1997) [Pubmed]
  8. Androgen induction of in vitro prostate cell differentiation. Whitacre, D.C., Chauhan, S., Davis, T., Gordon, D., Cress, A.E., Miesfeld, R.L. Cell Growth Differ. (2002) [Pubmed]
  9. Loss of homotypic epithelial cell adhesion by selective N-cadherin displacement in bismuth nephrotoxicity. Leussink, B.T., Litvinov, S.V., de Heer, E., Slikkerveer, A., van der Voet, G.B., Bruijn, J.A., de Wolff, F.A. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  10. Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium. Angst, B.D., Khan, L.U., Severs, N.J., Whitely, K., Rothery, S., Thompson, R.P., Magee, A.I., Gourdie, R.G. Circ. Res. (1997) [Pubmed]
  11. Assembly and remodelling of myofibrils and intercalated discs in cultured neonatal rat heart cells. Atherton, B.T., Meyer, D.M., Simpson, D.G. J. Cell. Sci. (1986) [Pubmed]
  12. Formation of the tooth enamel rod pattern and the cytoskeletal organization in secretory ameloblasts of the rat incisor. Nishikawa, S., Fujiwara, K., Kitamura, H. Eur. J. Cell Biol. (1988) [Pubmed]
  13. Development and characterization of conditionally immortalized gastric epithelial cell lines from transgenic rats harboring temperature-sensitive simian virus 40 large T-antigen gene. Tabuchi, Y., Arai, Y., Ohta, S., Shioya, H., Takahashi, R., Ueda, M., Takeguchi, N., Asano, S., Obinata, M. Cell Struct. Funct. (2002) [Pubmed]
  14. Changes in cytokeratin, vimentin and desmoplakin distribution during the repair of irradiation-induced lung injury in adult rats. Kasper, M., Rudolf, T., Haase, M., Schuh, D., Müller, M. Virchows Arch., B, Cell Pathol. (1993) [Pubmed]
  15. Role of cytokeratin intermediate filaments in transhepatic transport and canalicular secretion. Kawahara, H., Cadrin, M., Perry, G., Autilio-Gambetti, L., Swierenga, S.H., Metuzals, J., Marceau, N., French, S.W. Hepatology (1990) [Pubmed]
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