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Gene Review

v  -  vermilion

Drosophila melanogaster

Synonyms: 152559_at, CG2155, CG5163, DmTDO, Dmel\CG2155, ...
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Disease relevance of v


High impact information on v

  • We estimated DNA sequence variation within and between four populations of Drosophila ananassae at Om(1D) and vermilion (v) by using single-strand conformation polymorphism analysis and direct DNA sequencing [2].
  • The possibility that tyrosine tRNA modifies the catalytic activity of tryptophan oxygenase that is produced by the vermilion mutant (v) in Drosophila melanogaster is reconsidered [3].
  • Mechanism of suppression in Drosophila. VII. Correlation between disappearance of an isoacceptor of tyrosine tRNA and activation of the vermilion locus [3].
  • We surveyed sequence variation in four X-linked genes (runt, sevenless, Sex-lethal, and vermilion) that have been used in a parallel study in the closely related species D. melanogaster [4].
  • Specific locus mutations generated in the vermilion gene by CEA under NER(-) conditions were almost exclusively base pair substitutions (93%) [5].

Biological context of v


Anatomical context of v


Associations of v with chemical compounds


Other interactions of v

  • Males with one of three recessive mutants: White, vermilion, or vestigial, competed with wild type males for females [16].
  • We have estimated DNA sequence variation within and between two populations of Drosophila ananassae, using six-cutter restriction site variation at vermilion (v) and furrowed (fw) [17].
  • The other essential segment lies between the crossveinless and vermilion loci and may contain multiple factors that influence the attachment process [18].
  • The focuses of the l(1)BP4 gene do not coincide with the known focuses of vermilion and sevenless genes, which means that all three genes are active in different tissues [19].
  • This paper describes the genetic analysis of X-ray-induced mutations at several visible loci (yellow, white, Notch, vermilion and forked) located on the X-chromosome of Drosophila melanogaster after recovery in excision repair-deficient condition (mus-201) [20].

Analytical, diagnostic and therapeutic context of v


  1. The Anopheles gambiae tryptophan oxygenase gene expressed from a baculovirus promoter complements Drosophila melanogaster vermilion. Besansky, N.J., Mukabayire, O., Benedict, M.Q., Rafferty, C.S., Hamm, D.M., Mcnitt, L. Insect Biochem. Mol. Biol. (1997) [Pubmed]
  2. A test of the background selection hypothesis based on nucleotide data from Drosophila ananassae. Stephan, W., Xing, L., Kirby, D.A., Braverman, J.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Mechanism of suppression in Drosophila. VII. Correlation between disappearance of an isoacceptor of tyrosine tRNA and activation of the vermilion locus. Jacobson, K.B. Nucleic Acids Res. (1978) [Pubmed]
  4. Contrasted polymorphism patterns in a large sample of populations from the evolutionary genetics model Drosophila simulans. Baudry, E., Derome, N., Huet, M., Veuille, M. Genetics (2006) [Pubmed]
  5. The in vivo genetic activity profile of the monofunctional nitrogen mustard 2-chloroethylamine differs drastically from its bifunctional counterpart mechlorethamine. Wijen, J.P., Nivard, M.J., Vogel, E.W. Carcinogenesis (2000) [Pubmed]
  6. Structure and transcription of the Drosophila melanogaster vermilion gene and several mutant alleles. Searles, L.L., Ruth, R.S., Pret, A.M., Fridell, R.A., Ali, A.J. Mol. Cell. Biol. (1990) [Pubmed]
  7. Molecular genetic variation in the centromeric region of the X chromosome in three Drosophila ananassae populations. I. Contrasts between the vermilion and forked loci. Stephan, W., Langley, C.H. Genetics (1989) [Pubmed]
  8. Mutation spectra of 1,2-dibromoethane, 1,2-dichloroethane and 1-bromo-2-chloroethane in excision repair proficient and repair deficient strains of Drosophila melanogaster. Ballering, L.A., Nivard, M.J., Vogel, E.W. Carcinogenesis (1994) [Pubmed]
  9. The cross-linking agent hexamethylphosphoramide predominantly induces intra-locus and multi-locus deletions in postmeiotic germ cells of Drosophila. Aguirrezabalaga, I., Nivard, M.J., Comendador, M.A., Vogel, E.W. Genetics (1995) [Pubmed]
  10. Molecular variation at the vermilion locus in geographically diverse populations of Drosophila melanogaster and D. simulans. Begun, D.J., Aquadro, C.F. Genetics (1995) [Pubmed]
  11. O-ethylthymidine adducts are the most relevant damages for mutation induced by N-ethyl-N-nitrosourea in female germ cells of Drosophila melanogaster. Alvarez, L., Comendador, M.A., Sierra, L.M. Environ. Mol. Mutagen. (2002) [Pubmed]
  12. Neutron- and X-ray-induced mutations at the yellow, white, forked and vermilion loci of Drosophila melanogaster; a preliminary analysis. Leigh, B., Schalet, A.P., Paradi, E. Mutat. Res. (1982) [Pubmed]
  13. Age-dependent changes in memory and mushroom bodies in the Drosophila mutant vermilion deficient in the kynurenine pathway of tryptophan metabolism. Savvateeva, E.V., Popov, A.V., Kamyshev, N.G., Iliadi, K.G., Bragina, J.V., Heisenberg, M., Kornhuber, J., Riederer, P. Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. (1999) [Pubmed]
  14. Molecular analysis of mutations induced in the vermilion gene of Drosophila melanogaster by methyl methanesulfonate. Nivard, M.J., Pastink, A., Vogel, E.W. Genetics (1992) [Pubmed]
  15. Preferential formation of deletions following in vivo exposure of postmeiotic Drosophila germ cells to the DNA etheno-adduct-forming carcinogen vinyl carbamate. Ballering, L.A., Nivard, M.J., Vogel, E.W. Environ. Mol. Mutagen. (1997) [Pubmed]
  16. Success of mutant Drosophila at different sex ratios. Just, J., Markow, T. Hereditas (1989) [Pubmed]
  17. Reduced levels of DNA polymorphism and fixed between-population differences in the centromeric region of Drosophila ananassae. Stephan, W., Mitchell, S.J. Genetics (1992) [Pubmed]
  18. Spontaneous formation of compound X chromosomes in Drosophila melanogaster. Morrison, R.J., Raymond, J.D., Zunt, J.R., Lim, J.K., Simmons, M.J. Genetics (1988) [Pubmed]
  19. Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. III. The fate mapping of the lethal focus of the l(1)BP4 gene. Bgatov, A.V., Zharkikh, A.A., Zhimulev, I.F. Mol. Gen. Genet. (1984) [Pubmed]
  20. The nature of X-ray-induced mutations after recovery in excision repair-deficient (mus-201) Drosophila females. Eeken, J.C., Vreeken, C., de Jong, A.W., Pastink, A. Mutat. Res. (1991) [Pubmed]
  21. Sequence analysis of N-ethyl-N-nitrosourea-induced vermilion mutations in Drosophila melanogaster. Pastink, A., Vreeken, C., Nivard, M.J., Searles, L.L., Vogel, E.W. Genetics (1989) [Pubmed]
  22. Genetic effects of exocyclic DNA adducts in vivo: heritable genetic damage in comparison with loss of heterozygosity in somatic cells. Nivard, M.J., Vogel, E.W. IARC Sci. Publ. (1999) [Pubmed]
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