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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

BK Virus

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Disease relevance of BK Virus


High impact information on BK Virus

  • CONCLUSIONS: Testing for BK virus DNA in plasma from renal-allograft recipients with use of the polymerase chain reaction is a sensitive and specific method for identifying viral nephropathy [6].
  • Antibody increases to BK virus were associated with a rising seurum creatinine (P = 0.02) and need for transplant biopsy (P = 0.02) [7].
  • BK virus (BKV), which infects a large percentage of the human population and has been associated with a variety of human tumors, encodes a TAg homologous to SV40 TAg [8].
  • Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains [8].
  • By creating deletion mutants, we determined that the high-level activation of the hybrid BL transcriptional unit by the E1A proteins requires both MLP sequences and an intact BK virus enhancer [9].

Chemical compound and disease context of BK Virus

  • In addition, the MLP could be cis-activated by the BK virus enhancer in both human and monkey kidney cells; approximately 20 times more chloramphenicol acetyltransferase was produced from expression vectors containing a hybrid promoter (BL), in which the BK enhancer was upstream of the MLP, than from expression vectors containing the MLP alone [9].
  • The relative contributions of cyclophosphamide metabolites and BK virus in the development of HC following BMT are unknown [10].
  • The effect of steroid hormones on multiplication of the human polyomavirus BK (BKV) was studied [11].
  • An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus [12].
  • A comparison of the proteins of BK virus and SV40 iodinated with chloramine T before and after disruption in alkaline buffer at pH 10.5 revealed differences between the two viruses in the number and distribution of tyrosines available for iodination [13].

Biological context of BK Virus


Anatomical context of BK Virus

  • We have monitored BK virus (BKV) antigen expression and multiplication in human monocytes and in a human macrophage (M luminal diameter)-like cell line (U937) in the presence or absence of dilution series of human or rabbit anti-BKV antisera [19].
  • Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector [20].

Gene context of BK Virus


Analytical, diagnostic and therapeutic context of BK Virus


  1. BK virus-plasmid expression vector that persists episomally in human cells and shuttles into Escherichia coli. Milanesi, G., Barbanti-Brodano, G., Negrini, M., Lee, D., Corallini, A., Caputo, A., Grossi, M.P., Ricciardi, R.P. Mol. Cell. Biol. (1984) [Pubmed]
  2. Cell-specific modulation of the papovavirus promoters by tumor-suppressor protein p53 in the absence of large T-antigen. Das, G.C., Shivakumar, C.V., Todd, S.D. Oncogene (1995) [Pubmed]
  3. Promotion of tumour metastases and induction of angiogenesis by native HIV-1 Tat protein from BK virus/tat transgenic mice. Corallini, A., Campioni, D., Rossi, C., Albini, A., Possati, L., Rusnati, M., Gazzanelli, G., Benelli, R., Masiello, L., Sparacciari, V., Presta, M., Mannello, F., Fontanini, G., Barbanti-Brodano, G. AIDS (1996) [Pubmed]
  4. Relationship between the methionine tryptic peptides of simian virus 40 and BK virus tumor antigens. Simmons, D.T., Takemoto, K.K., Martin, M.A. J. Virol. (1977) [Pubmed]
  5. Transcription of BK virus DNA by Escherichia coli RNA polymerase: size and sequence analysis of RNA. Meneguzzi, G., Milanesi, G. J. Virol. (1978) [Pubmed]
  6. Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. Nickeleit, V., Klimkait, T., Binet, I.F., Dalquen, P., Del Zenero, V., Thiel, G., Mihatsch, M.J., Hirsch, H.H. N. Engl. J. Med. (2000) [Pubmed]
  7. Human polyomavirus infections with JC virus and BK virus in renal transplant patients. Hogan, T.F., Borden, E.C., McBain, J.A., Padgett, B.L., Walker, D.L. Ann. Intern. Med. (1980) [Pubmed]
  8. Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains. Harris, K.F., Christensen, J.B., Radany, E.H., Imperiale, M.J. Mol. Cell. Biol. (1998) [Pubmed]
  9. Activation of the adenovirus and BK virus late promoters: effects of the BK virus enhancer and trans-acting viral early proteins. Grinnell, B.W., Berg, D.T., Walls, J. Mol. Cell. Biol. (1986) [Pubmed]
  10. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. Bedi, A., Miller, C.B., Hanson, J.L., Goodman, S., Ambinder, R.F., Charache, P., Arthur, R.R., Jones, R.J. J. Clin. Oncol. (1995) [Pubmed]
  11. A steroid hormone response unit in the late leader of the noncoding control region of the human polyomavirus BK confers enhanced host cell permissivity. Moens, U., Subramaniam, N., Johansen, B., Johansen, T., Traavik, T. J. Virol. (1994) [Pubmed]
  12. An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus. Dugan, A.S., Eash, S., Atwood, W.J. J. Virol. (2005) [Pubmed]
  13. Virion polypeptide composition of the human papovavirus BK: comparison with simian virus 40 and polyoma virus. Wright, P.J., Di Mayorca, G. J. Virol. (1975) [Pubmed]
  14. Nucleotide sequence of the human polyomavirus AS virus, an antigenic variant of BK virus. Tavis, J.E., Walker, D.L., Gardner, S.D., Frisque, R.J. J. Virol. (1989) [Pubmed]
  15. Isolation of a papovavirus with a bipartite genome containing unlinked SV40 and BKV sequences. O'Neill, F.J., Miller, T.H. Virology (1985) [Pubmed]
  16. Cross-reaction of BK virus large T antigen with monoclonal antibodies directed against SV40 large T antigen. Mann, R.S., Carroll, R.B. Virology (1984) [Pubmed]
  17. BK virus antigenic variants: sequence analysis within the capsid VP1 epitope. Jin, L., Gibson, P.E., Knowles, W.A., Clewley, J.P. J. Med. Virol. (1993) [Pubmed]
  18. Transforming potential of DNA of the human PLC/PRF/5 hepatoma cell line. Iwamura, Y., Mitamura, K., Yanagi, K., Hashimoto, T., Kato, K. Intervirology (1986) [Pubmed]
  19. Antibody-mediated enhancement of BK virus infection in human monocytes and a human macrophage-like cell line. Traavik, T., Uhlin-Hansen, L., Flaegstad, T., Christie, K.E. J. Med. Virol. (1988) [Pubmed]
  20. Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector. Caputo, A., Sodroski, J.G., Haseltine, W.A. J. Acquir. Immune Defic. Syndr. (1990) [Pubmed]
  21. Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction. Hu, H., Aizenstein, B.D., Puchalski, A., Burmania, J.A., Hamawy, M.M., Knechtle, S.J. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2004) [Pubmed]
  22. Polymorphism in the genome of non-passaged human polyomavirus BK: implications for cell tropism and the pathological role of the virus. Moens, U., Van Ghelue, M. Virology (2005) [Pubmed]
  23. A monoclonal antibody specific for BK virus large T-antigen (clone BK.T-1) also binds the human Ku autoantigen. Zambrano, A., Villarreal, L.P. Oncogene (2002) [Pubmed]
  24. Structure and assembly of a T=1 virus-like particle in BK polyomavirus. Nilsson, J., Miyazaki, N., Xing, L., Wu, B., Hammar, L., Li, T.C., Takeda, N., Miyamura, T., Cheng, R.H. J. Virol. (2005) [Pubmed]
  25. Fatal BK polyoma viral pneumonia associated with immunosuppression. Galan, A., Rauch, C.A., Otis, C.N. Hum. Pathol. (2005) [Pubmed]
  26. Antibodies against BK virus in renal transplant recipient sera: results with five different methods indicate frequent reactivations. Flaegstad, T., Nilsen, I., Skar, A.G., Traavik, T. Scand. J. Infect. Dis. (1991) [Pubmed]
  27. BK virus infection in kidney transplant recipients. Kim, H.C., Hwang, E.A., Kang, M.J., Han, S.Y., Park, S.B., Park, K.K. Transplant. Proc. (2004) [Pubmed]
  28. The importance of pre-treatment of human sera for the titration of hemagglutination-inhibiting antibodies towards BK virus. De Stasio, A., Orsi, N., Panà, A., Seganti, L., Sinibaldi, S., Valenti, P. Annali Sclavo; rivista di microbiologia e di immunologia. (1979) [Pubmed]
  29. Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome. Koelle, D.M., Barcy, S., Huang, M.L., Ashley, R.L., Corey, L., Zeh, J., Ashton, S., Buchwald, D. Clin. Infect. Dis. (2002) [Pubmed]
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