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Gene Review

SAB1192  -  catalase

Staphylococcus aureus RF122

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Disease relevance of SAB1192


High impact information on SAB1192

  • Addition of superoxide dismutase or catalase to the O2.- generating system resulted in protection of thermally stressed and nonstressed cells, with the protective effect being greater for thermally stressed cells [6].
  • It was positive for urease, oxidase, catalase, glycosidases, porphyrin, and indole, and it fermented glucose and sucrose [7].
  • The effects of the addition of catalase (EC or pyruvate on the enumeration of Staphylococcus aureus in Trypticase soy broth with 10% NaCl were examined using a most-probable-number technique [8].
  • Of 289 isolates of catalase-positive, gram-positive cocci, 122 were identified as S. aureus based on positive reactions in at least three of the following tests: tube coagulase, slide coagulase, DNase production, or anaerobic fermentation of mannitol [9].
  • Immunochemical titration experiments with rabbit antiserum against the purified peroxisomal catalase from alkane-grown C. tropicalis indicated that the remarkable variation in the enzyme activity level on different carbon sources was ascribable to a corresponding change in the amount of the enzyme protein [10].

Chemical compound and disease context of SAB1192


Biological context of SAB1192

  • To gain information on metabolic control and peroxisome biogenesis in Candida tropicalis growing on n-alkanes, cell-free translation of catalase (H2O2:H2O2 oxidoreductase, EC, a general marker enzyme of peroxisomes, was performed [10].
  • When the original Delta 1058::Tn551 mutation was transduced into the hemolytic, catalase-positive variant of S6C, none of the transductants exhibited an exoprotein-deficient phenotype [12].
  • The biochemical parameters such as hydroxyproline, protein, DNA, uronic acid, hexosamine, SOD, and catalase content in the granulation tissue of the healing wound revealed increased proliferation of cells involved in tissue reconstruction in PIC-treated groups when compared with OW- and CF-treated groups [13].

Anatomical context of SAB1192

  • When cell-free translation was carried out with the mRNA-dependent reticulocyte lysate system, total RNA prepared from alkane-grown cells was shown to direct the synthesis of catalase subunit in vitro [10].

Associations of SAB1192 with chemical compounds

  • Addition of catalase or pyruvate to the broth increased enumeration of all heat-stressed S. aureus strains tested [8].
  • S. aureus strains with reduced catalase activity show greater sensitivity to oleuropein [14].
  • Hydrogen peroxide resistance could be partly explained by the high catalase activity in the dead-cell fraction [15].
  • These tests were as follows; catalase, oxidase, fermentation and oxidation of glucose and mannitol, v.p. and coagulase activity, heat resistance endonuclease, and lipase production [16].
  • The following procedures are recommended for routine use: Idnetification of Staphylococcus sp. (clinical laboratories): microscopic observation, catalase activity, coagulase production, lysostaphin sensitivity, and (optional) facultative growth in thioglycolate medium [17].

Analytical, diagnostic and therapeutic context of SAB1192

  • The assay was a modification of a 'sandwich' ELISA for the protein A of Staph. aureus, employing catalase-labelled anti-protein A antibody [18].


  1. Synthesis of catalase in Staphylococcus aureus MF-31. Martin, S.E., Chaven, S. Appl. Environ. Microbiol. (1987) [Pubmed]
  2. Clinical laboratory evaluation of the thermonuclease test. Shanholtzer, C.J., Peterson, L.R. Am. J. Clin. Pathol. (1982) [Pubmed]
  3. Corynebacterium camporealensis sp. nov., associated with subclinical mastitis in sheep. Fernández-Garayzábal, J.F., Collins, M.D., Hutson, R.A., Gonzalez, I., Fernández, E., Domínguez, L. Int. J. Syst. Bacteriol. (1998) [Pubmed]
  4. Comparative immunological study of catalases in the genus Micrococcus. Rupprecht, M., Schleifer, K.H. Arch. Microbiol. (1977) [Pubmed]
  5. The effect of interfering substances on the disinfection process: a mathematical model. Lambert, R.J., Johnston, M.D. J. Appl. Microbiol. (2001) [Pubmed]
  6. Effect of free-radical scavengers on enumeration of thermally stressed cells of Staphylococcus aureus MF-31. Bucker, E.R., Martin, S.E. Appl. Environ. Microbiol. (1982) [Pubmed]
  7. Characterization of a Haemophilus paracuniculus isolated from gastrointestinal tracts of rabbits with mucoid enteritis. Targowski, S., Targowski, H. J. Clin. Microbiol. (1979) [Pubmed]
  8. Beneficial effects of catalase or pyruvate in a most-probable-number technique for the detection of Staphylococcus aureus. Brewer, D.G., Martin, S.E., Ordal, Z.J. Appl. Environ. Microbiol. (1977) [Pubmed]
  9. Evaluation of latex agglutination and microtube coagulase tests for detection of Staphylococcus aureus. Pourshadi, M., Klaas, J. Diagn. Microbiol. Infect. Dis. (1984) [Pubmed]
  10. Cell-free translation and regulation of Candida tropicalis catalase messenger RNA. Yamada, T., Tanaka, A., Horikawa, S., Numa, S., Fukui, S. Eur. J. Biochem. (1982) [Pubmed]
  11. The effect of catalase on the toxicity of cadmium in cadmium-sensitive and cadmium-resistant Staphylococcus aureus. Korkeala, H., Sankari, S. Acta Vet. Scand. (1980) [Pubmed]
  12. Isolation of stable hemolysin and catalase variants of Staphylococcus aureus S6C includes one with an exoprotein-deficient phenotype. Hart, M.E., Crum, R.M., St John-Tidwell, M.A., Malakowsky, C.A. Curr. Microbiol. (2001) [Pubmed]
  13. Pexiganan-incorporated collagen matrices for infected wound-healing processes in rat. Gopinath, D., Kumar, M.S., Selvaraj, D., Jayakumar, R. Journal of biomedical materials research. Part A. (2005) [Pubmed]
  14. Inhibition of Staphylococcus aureus by oleuropein is mediated by hydrogen peroxide. Zanichelli, D., Baker, T.A., Clifford, M.N., Adams, M.R. J. Food Prot. (2005) [Pubmed]
  15. The effect of the growth phase of Staphylococcus aureus on resistance to disinfectants in a suspension test. Luppens, S.B., Rombouts, F.M., Abee, T. J. Food Prot. (2002) [Pubmed]
  16. Evaluation of 8 physiological characteristics of clinically isolated Staphylococci and Micrococci. Lashkari, K.B., Yazdany, S., Khataizadeh, H. Acta medica Iranica. (1976) [Pubmed]
  17. The identification of staphylococci in clinical and food microbiology laboratories. Sperber, W.H. CRC critical reviews in clinical laboratory sciences. (1976) [Pubmed]
  18. Development and performance of an enzyme-linked amperometric immunosensor for the detection of Staphylococcus aureus in foods. Mirhabibollahi, B., Brooks, J.L., Kroll, R.G. J. Appl. Bacteriol. (1990) [Pubmed]
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