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Chemical Compound Review

AC1O533P     (4S,5Z,6S)-4-[2-(3,4- dihydroxyphenyl)ethox...

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Disease relevance of Oleuropein

  • Thgoal of this study was to evaluate the efficacy of the antioxidant olive constituent, oleuropein, on infarct size, oxidative damage, and the metabolic profile in rabbits subjected to ischemia [1].
  • The 52 remaining OVX rats were allocated to 4 groups that received oleuropein at 2.5, 5, 10 or 15mg/kg body weight per day for 100 days [2].
  • Inhibition of Staphylococcus aureus by oleuropein is mediated by hydrogen peroxide [3].
  • The reported data provide the first experimental evidence of a direct cardioprotective effect of oleuropein in the acute events that follow coronary occlusion, likely because of its antioxidant properties [4].
  • Inhibition of Salmonella enteritidis by oleuropein in broth and in a model food system [5].

High impact information on Oleuropein


Chemical compound and disease context of Oleuropein


Biological context of Oleuropein


Anatomical context of Oleuropein


Associations of Oleuropein with other chemical compounds


Gene context of Oleuropein


Analytical, diagnostic and therapeutic context of Oleuropein

  • CONCLUSIONS: Every dose of oleuropein elicited protective effects on bone mass in this model of ovariectomy associated with inflammation, probably by modulating inflammatory parameters [2].
  • Three weeks before necropsy, an inflammation was induced by subcutaneous injections of talc in half of the SH and OVX rats and in all oleuropein-treated animals [2].
  • Rapid high-performance liquid chromatography analysis for the quantitative determination of oleuropein in Olea europaea leaves [28].
  • The determination of antioxidants was performed using HPLC, and the K(p) was estimated to be from as low as 0.0006 for oleuropein to a maximum of 1.5 for 3,4-DHPEA-EA (di-hydroxy-phenyl-ethanol-elenolic acid, oleuropein aglycon) [29].
  • The proposed bioreactor could also find application in the utilization of olive mill waste waters (OMWW), medium rich in large amounts of oleuropein, which can be converted in pharmacologically active compounds [30].


  1. The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits. Andreadou, I., Iliodromitis, E.K., Mikros, E., Constantinou, M., Agalias, A., Magiatis, P., Skaltsounis, A.L., Kamber, E., Tsantili-Kakoulidou, A., Kremastinos, D.T. J. Nutr. (2006) [Pubmed]
  2. Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Puel, C., Mathey, J., Agalias, A., Kati-Coulibaly, S., Mardon, J., Obled, C., Davicco, M.J., Lebecque, P., Horcajada, M.N., Skaltsounis, A.L., Coxam, V. Clinical nutrition (Edinburgh, Scotland) (2006) [Pubmed]
  3. Inhibition of Staphylococcus aureus by oleuropein is mediated by hydrogen peroxide. Zanichelli, D., Baker, T.A., Clifford, M.N., Adams, M.R. J. Food Prot. (2005) [Pubmed]
  4. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. Manna, C., Migliardi, V., Golino, P., Scognamiglio, A., Galletti, P., Chiariello, M., Zappia, V. J. Nutr. Biochem. (2004) [Pubmed]
  5. Inhibition of Salmonella enteritidis by oleuropein in broth and in a model food system. Tassou, C.C., Nychas, G.J. Lett. Appl. Microbiol. (1995) [Pubmed]
  6. Absolute method for the assay of oleuropein in olive oils by atmospheric pressure chemical ionization tandem mass spectrometry. De Nino, A., Di Donna, L., Mazzotti, F., Muzzalupo, E., Perri, E., Sindona, G., Tagarelli, A. Anal. Chem. (2005) [Pubmed]
  7. Noncovalent Interaction Between Amyloid-beta-Peptide (1-40) and Oleuropein Studied by Electrospray Ionization Mass Spectrometry. Bazoti, F.N., Bergquist, J., Markides, K.E., Tsarbopoulos, A. J. Am. Soc. Mass Spectrom. (2006) [Pubmed]
  8. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Al-Azzawie, H.F., Alhamdani, M.S. Life Sci. (2006) [Pubmed]
  9. Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat. Puel, C., Quintin, A., Agalias, A., Mathey, J., Obled, C., Mazur, A., Davicco, M.J., Lebecque, P., Skaltsounis, A.L., Coxam, V. Br. J. Nutr. (2004) [Pubmed]
  10. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Micol, V., Caturla, N., Pérez-Fons, L., Más, V., Pérez, L., Estepa, A. Antiviral Res. (2005) [Pubmed]
  11. Simultaneous determination of oleuropein and hydroxytyrosol in rat plasma using liquid chromatography with fluorescence detection. Tan, H.W., Tuck, K.L., Stupans, I., Hayball, P.J. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2003) [Pubmed]
  12. Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration. Visioli, F., Galli, C., Grande, S., Colonnelli, K., Patelli, C., Galli, G., Caruso, D. J. Nutr. (2003) [Pubmed]
  13. Oleuropein, an antioxidant polyphenol from olive oil, is poorly absorbed from isolated perfused rat intestine. Edgecombe, S.C., Stretch, G.L., Hayball, P.J. J. Nutr. (2000) [Pubmed]
  14. Free radical-scavenging properties of olive oil polyphenols. Visioli, F., Bellomo, G., Galli, C. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  15. Bioactive derivatives from oleuropein by a biotransformation on Olea europaea leaf extracts. Briante, R., La Cara, F., Febbraio, F., Patumi, M., Nucci, R. J. Biotechnol. (2002) [Pubmed]
  16. Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil. de la Puerta, R., Ruiz Gutierrez, V., Hoult, J.R. Biochem. Pharmacol. (1999) [Pubmed]
  17. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Hamdi, H.K., Castellon, R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  18. Differential effects of oleuropein, a biophenol from Olea europaea, on anionic and zwiterionic phospholipid model membranes. Caturla, N., Pérez-Fons, L., Estepa, A., Micol, V. Chem. Phys. Lipids (2005) [Pubmed]
  19. Effects of polyphenols on human Th1 and Th2 cytokine production. Miles, E.A., Zoubouli, P., Calder, P.C. Clinical nutrition (Edinburgh, Scotland) (2005) [Pubmed]
  20. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Visioli, F., Bellosta, S., Galli, C. Life Sci. (1998) [Pubmed]
  21. Activity and location of olive oil phenolic antioxidants in liposomes. Paiva-Martins, F., Gordon, M.H., Gameiro, P. Chem. Phys. Lipids (2003) [Pubmed]
  22. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. Valavanidis, A., Nisiotou, C., Papageorgiou, Y., Kremli, I., Satravelas, N., Zinieris, N., Zygalaki, H. J. Agric. Food Chem. (2004) [Pubmed]
  23. Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Kruk, I., Aboul-Enein, H.Y., Michalska, T., Lichszteld, K., Kładna, A. Luminescence : the journal of biological and chemical luminescence. (2005) [Pubmed]
  24. Hydrolysis of oleuropein by recombinant beta-glycosidase from hyperthermophilic archaeon Sulfolobus solfataricus immobilised on chitosan matrix. Briante, R., La Cara, F., Febbraio, F., Barone, R., Piccialli, G., Carolla, R., Mainolfi, P., De Napoli, L., Patumi, M., Fontanazza, G., Nucci, R. J. Biotechnol. (2000) [Pubmed]
  25. Inactivation of cytochrome P450 by the food-derived complex phenol oleuropein. Stupans, I., Murray, M., Kirlich, A., Tuck, K.L., Hayball, P.J. Food Chem. Toxicol. (2001) [Pubmed]
  26. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Carluccio, M.A., Siculella, L., Ancora, M.A., Massaro, M., Scoditti, E., Storelli, C., Visioli, F., Distante, A., De Caterina, R. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  27. Pro-oxidant Activity of Oleuropein Determined in Vitro by Electron Spin Resonance Spin-Trapping Methodology. Mazziotti, A., Mazzotti, F., Pantusa, M., Sportelli, L., Sindona, G. J. Agric. Food Chem. (2006) [Pubmed]
  28. Rapid high-performance liquid chromatography analysis for the quantitative determination of oleuropein in Olea europaea leaves. Savournin, C., Baghdikian, B., Elias, R., Dargouth-Kesraoui, F., Boukef, K., Balansard, G. J. Agric. Food Chem. (2001) [Pubmed]
  29. Partitioning of olive oil antioxidants between oil and water phases. Rodis, P.S., Karathanos, V.T., Mantzavinou, A. J. Agric. Food Chem. (2002) [Pubmed]
  30. Production of highly purified hydroxytyrosol from Olea europaea leaf extract biotransformed by hyperthermophilic beta-glycosidase. Briante, R., Patumi, M., Febbraio, F., Nucci, R. J. Biotechnol. (2004) [Pubmed]
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