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Gene Review

OCLN  -  occludin

Gallus gallus

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Disease relevance of LOC396026

  • When chicken occludin was overexpressed in insect cells by recombinant baculovirus infection, peculiar multilamellar structures accumulated in the cytoplasm [1].

High impact information on LOC396026


Biological context of LOC396026


Anatomical context of LOC396026


Associations of LOC396026 with chemical compounds

  • Once steady state transepithelial electrical resistance was achieved, isopropyl- beta-D-thiogalactoside was added to induce chick occludin expression [7].
  • Two days after plating confluent monolayers that were induced to express chick occludin, mannitol flux was reduced to a variable degree relative to control monolayers [7].
  • Under supplementation with DMSO, immunofluorescently demonstrable occludin and ZO-1 were induced progressively at cell borders in parallel with the increase in TER that occurred with decreases in inulin and dextran permeability [10].
  • The existence of a blood-brain barrier is demonstrated by the exclusion of intravascularly injected tracer (horseradish peroxidase), and immunocytochemical demonstration of glucose transporter-1 as a functional marker and of neurothelin, occludin and ZO-1 as structural markers [11].

Other interactions of LOC396026


Analytical, diagnostic and therapeutic context of LOC396026


  1. Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. Furuse, M., Fujimoto, K., Sato, N., Hirase, T., Tsukita, S., Tsukita, S. J. Cell. Sci. (1996) [Pubmed]
  2. COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. Chen, Y., Merzdorf, C., Paul, D.L., Goodenough, D.A. J. Cell Biol. (1997) [Pubmed]
  3. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. Balda, M.S., Whitney, J.A., Flores, C., González, S., Cereijido, M., Matter, K. J. Cell Biol. (1996) [Pubmed]
  4. Biogenesis of tight junctions: the C-terminal domain of occludin mediates basolateral targeting. Matter, K., Balda, M.S. J. Cell. Sci. (1998) [Pubmed]
  5. Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin. Cordenonsi, M., Turco, F., D'atri, F., Hammar, E., Martinucci, G., Meggio, F., Citi, S. Eur. J. Biochem. (1999) [Pubmed]
  6. Occludin: a novel integral membrane protein localizing at tight junctions. Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., Tsukita, S. J. Cell Biol. (1993) [Pubmed]
  7. Occludin is a functional component of the tight junction. McCarthy, K.M., Skare, I.B., Stankewich, M.C., Furuse, M., Tsukita, S., Rogers, R.A., Lynch, R.D., Schneeberger, E.E. J. Cell. Sci. (1996) [Pubmed]
  8. Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression. Schuster, M.K., Schmierer, B., Shkumatava, A., Kuchler, K. Biol. Reprod. (2004) [Pubmed]
  9. Developmental expression of the tight junction protein, occludin, in the gastrointestinal tract of the chick embryo. Kawasaki, K., Hayashi, Y., Nishida, Y., Miki, A., Itoh, H. Histochem. Cell Biol. (1998) [Pubmed]
  10. Development of the blood-retinal barrier in vitro: formation of tight junctions as revealed by occludin and ZO-1 correlates with the barrier function of chick retinal pigment epithelial cells. Konari, K., Sawada, N., Zhong, Y., Isomura, H., Nakagawa, T., Mori, M. Exp. Eye Res. (1995) [Pubmed]
  11. The blood-brain barrier of the chick glycogen body (corpus gelatinosum) and its functional implications. Möller, W., Kummer, W. Cell Tissue Res. (2003) [Pubmed]
  12. Simultaneous cell death and desquamation of the embryonic diffusion barrier during epidermal development. Saathoff, M., Blum, B., Quast, T., Kirfel, G., Herzog, V. Exp. Cell Res. (2004) [Pubmed]
  13. N-cadherin expression in endothelial cells during early angiogenesis in the eye and brain of the chicken: relation to blood-retina and blood-brain barrier development. Gerhardt, H., Liebner, S., Redies, C., Wolburg, H. Eur. J. Neurosci. (1999) [Pubmed]
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