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Gene Review

ADRB1  -  adrenoceptor beta 1

Sus scrofa

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Disease relevance of ADRB1


High impact information on ADRB1

  • Fat cell beta 1-adrenergic receptors display Mr = 67,000 under reducing conditions and Mr = 54,000 under nonreducing conditions, as previously reported (Moxham, C. P., and Malbon, C. C. (1985) Biochemistry 24, 6072-6077) [2].
  • Peptide maps of beta 1-adrenergic receptors from the myocardial tissue of different species (pig versus rat) yield slightly different maps while the maps derived from the beta 2-adrenergic receptors of hamster lung and rat lung or erythrocytes reveal no interspecies differences [3].
  • The affinity of the 2-fluoro analogue for beta 1-adrenergic receptors (inhibition of the specific binding of [3H]dihydroalprenolol, rat cerebral cortical membranes) was 2 times greater, while the 6-fluoro analogue was 1450 times less than the parent [4].
  • The effects of tulobuterol in the saphenous vein (but not in the coronary artery) were antagonized by the selective beta-2 adrenergic blocker ICI 118,551 but were not affected by the selective beta-1 adrenergic inhibitor metoprolol [5].
  • Effects of the new selectively beta 1-adrenergic cardiotonic drug denopamine (TA-064), (-)-(R)-1-(p-hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]ethanol, on the adenylate cyclase-adenosine-3',5'-monophosphate (c-AMP) system of various tissues and cells in rats and guinea pigs were investigated in comparison with those of isoproterenol [6].

Biological context of ADRB1


Anatomical context of ADRB1


Associations of ADRB1 with chemical compounds


Regulatory relationships of ADRB1


Other interactions of ADRB1


  1. In vivo and in vitro characterization of the novel antiarrhythmic agent SSR149744C: electrophysiological, anti-adrenergic, and anti-angiotensin II effects. Gautier, P., Guillemare, E., Djandjighian, L., Marion, A., Planchenault, J., Bernhart, C., Herbert, J.M., Nisato, D. J. Cardiovasc. Pharmacol. (2004) [Pubmed]
  2. Mammalian beta 1- and beta 2-adrenergic receptors. Immunological and structural comparisons. Moxham, C.P., George, S.T., Graziano, M.P., Brandwein, H.J., Malbon, C.C. J. Biol. Chem. (1986) [Pubmed]
  3. Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps. Stiles, G.L., Strasser, R.H., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1983) [Pubmed]
  4. Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol. Adejare, A., Nie, J.Y., Hebel, D., Brackett, L.E., Choi, O., Gusovsky, F., Padgett, W.L., Daly, J.W., Creveling, C.R., Kirk, K.L. J. Med. Chem. (1991) [Pubmed]
  5. Beta-2 adrenergic responses to tulobuterol in airway smooth muscle, vascular smooth muscle and adrenergic nerves. Ruff, F., Zander, J.F., Edoute, Y., Santais, M.C., Flavahan, N.A., Verbeuren, T.J., Vanhoutte, P.M. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  6. Beta 1-adrenergic selectivity of the new cardiotonic agent denopamine in its stimulating effects on adenylate cyclase. Inamasu, M., Totsuka, T., Ikeo, T., Nagao, T., Takeyama, S. Biochem. Pharmacol. (1987) [Pubmed]
  7. Effect of feed restriction on adipose tissue transcript concentrations in genetically lean and obese pigs. McNeel, R.L., Ding, S.T., Smith, E.O., Mersmann, H.J. J. Anim. Sci. (2000) [Pubmed]
  8. Acute metabolic effects of adrenergic agents in swine. Mersmann, H.J. Am. J. Physiol. (1987) [Pubmed]
  9. Derivatives related to betaxolol with alpha- and beta-adrenergic activities. Leclerc, G., Decker, N., Schwartz, J. Arzneimittel-Forschung. (1985) [Pubmed]
  10. Properties of beta-adrenergic receptors on porcine corpora lutea and granulosa cells. Perkins, S.N., Cronin, M.J., Veldhuis, J.D. Endocrinology (1986) [Pubmed]
  11. Bovine anterior descending coronary artery possesses a homogeneous population of beta-1 adrenergic receptors. Purdy, R.E., Stupecky, G.L. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  12. Changes in membrane proteins in chronic mechanical overload of the heart. Swynghedauw, B. Am. J. Cardiol. (1990) [Pubmed]
  13. Isoeugenolol: a selective beta1-adrenergic antagonist with tracheal and vascular smooth muscle relaxant properties. Lin, Y.T., Wu, B.N., Horng, C.F., Huang, Y.C., Hong, S.J., Lo, Y.C., Cheng, C.J., Chen, I.J. Jpn. J. Pharmacol. (1999) [Pubmed]
  14. Effects of higenamine on regulation of ion transport in guinea pig distal colon. Liu, W., Sato, Y., Hosoda, Y., Hirasawa, K., Hanai, H. Jpn. J. Pharmacol. (2000) [Pubmed]
  15. Synthesis and irreversible beta-adrenergic blockade with a bromoacetamido derivative of betaxolol. Amlaiky, N., Leclerc, G. Journal of pharmaceutical sciences. (1985) [Pubmed]
  16. Ligand binding to the porcine adipose tissue beta-adrenergic receptor. Mersmann, H.J., McNeel, R.L. J. Anim. Sci. (1992) [Pubmed]
  17. Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing. Abou-Mohamed, G., Nagarajan, R., Ibrahim, T.M., Caldwell, R.W. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1996) [Pubmed]
  18. Protein kinase C regulates functional coupling of beta1-adrenergic receptors to Gi/o-mediated responses in cardiac myocytes. Belevych, A.E., Juranek, I., Harvey, R.D. FASEB J. (2004) [Pubmed]
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