The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

MMP14  -  matrix metallopeptidase 14 (membrane...

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MT1-MMP

  • These results implicate PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury [1].
  • At peak ischemia, MT1-MMP activity was increased by >40% in the ischemic region, with no change in the remote region, which persisted with reperfusion (P<0.05) [2].
  • Furthermore, in an isolated left ventricular myocyte model of I/R, hypoxia (simulated ischemia) induced a >70% increase in MT1-MMP abundance in myocytes, and confocal microscopy revealed MT1-MMP internalization during this time period and reemergence to the membrane with reperfusion [2].
  • To understand the induction mechanism of MMP-14 under atherogenic conditions, we examined its expression pattern in response to oxidized low-density lipoproteins (ox-LDLs) that are believed to play an important role in atherogenesis [3].

High impact information on MT1-MMP


Biological context of MT1-MMP

  • A porcine MT1-MMP cDNA composed of 3284 bp was isolated from an enamel organ-specific cDNA library [8].
  • Increased binding of SAF-1 to the MMP-14 promoter correlated with the transcriptional upregulation of MMP-14 gene [3].

Anatomical context of MT1-MMP


Associations of MT1-MMP with chemical compounds

  • No change in MT1-MMP mRNA was observed with LY-294002, because equivalent amounts of this mRNA were present in both injured and noninjured vessels [1].
  • The wortmannin sensitivity implicates phosphoinositide 3-kinase as a modulator of the MMP-2 but not the MMP-14 increase [5].

Other interactions of MT1-MMP

  • Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP [1].

Analytical, diagnostic and therapeutic context of MT1-MMP

  • Multiple tissue Northern blot analysis revealed that the MT1-MMP message was expressed highly in the enamel organ and pulp organ when compared to the expression levels observed in other non-mineralizing tissues [8].
  • Differential centrifugation revealed that the endosomal fraction (which contains subcellular organelles) within the ischemic myocardium was associated with a >135% increase in MT1-MMP (P<0.05) [2].


  1. Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP. Zahradka, P., Harding, G., Litchie, B., Thomas, S., Werner, J.P., Wilson, D.P., Yurkova, N. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  2. Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity. Deschamps, A.M., Yarbrough, W.M., Squires, C.E., Allen, R.A., McClister, D.M., Dowdy, K.B., McLean, J.E., Mingoia, J.T., Sample, J.A., Mukherjee, R., Spinale, F.G. Circulation (2005) [Pubmed]
  3. Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process. Ray, B.K., Shakya, A., Turk, J.R., Apte, S.S., Ray, A. Circ. Res. (2004) [Pubmed]
  4. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. Ohuchi, E., Imai, K., Fujii, Y., Sato, H., Seiki, M., Okada, Y. J. Biol. Chem. (1997) [Pubmed]
  5. Signaling pathways used in trabecular matrix metalloproteinase response to mechanical stretch. Bradley, J.M., Kelley, M.J., Rose, A., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  6. Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation. Coker, M.L., Jolly, J.R., Joffs, C., Etoh, T., Holder, J.R., Bond, B.R., Spinale, F.G. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  7. Localization of bradykinin B(2) receptor in the follicles of porcine ovary and increased expression of matrix metalloproteinase-3 and -20 in cultured granulosa cells by bradykinin treatment. Kimura, A., Kihara, T., Ohkura, R., Ogiwara, K., Takahashi, T. Biol. Reprod. (2001) [Pubmed]
  8. Expression and localization of membrane type 1 matrix metalloproteinase in tooth tissues. Caron, C., Xue, J., Bartlett, J.D. Matrix Biol. (1998) [Pubmed]
WikiGenes - Universities