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Gene Review

hpt  -  hypoxanthine phosphoribosyltransferase

Escherichia coli UTI89

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Disease relevance of hpt


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Chemical compound and disease context of hpt


Biological context of hpt


Associations of hpt with chemical compounds


Analytical, diagnostic and therapeutic context of hpt

  • To test whether the increase in the relative frequency of mutations resulted from inefficient repair at these sites, we adapted ligation-mediated PCR to measure the rates of removal of BPDE adducts from individual sites in exon 3 of the HPRT gene [5].


  1. Expression of the Methanobacterium thermoautotrophicum hpt gene, encoding hypoxanthine (Guanine) phosphoribosyltransferase, in Escherichia coli. Sauer, J., Nygaard, P. J. Bacteriol. (1999) [Pubmed]
  2. Isolation of purine auxotrophic mutants of Lactococcus lactis and characterization of the gene hpt encoding hypoxanthine guanine phosphoribosyltransferase. Nilsson, D., Lauridsen, A.A. Mol. Gen. Genet. (1992) [Pubmed]
  3. A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi. Focia, P.J., Craig, S.P., Nieves-Alicea, R., Fletterick, R.J., Eakin, A.E. Biochemistry (1998) [Pubmed]
  4. Microinjection and growth of bacteria in the cytosol of mammalian host cells. Goetz, M., Bubert, A., Wang, G., Chico-Calero, I., Vazquez-Boland, J.A., Beck, M., Slaghuis, J., Szalay, A.A., Goebel, W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Site-specific rates of excision repair of benzo[a]pyrene diol epoxide adducts in the hypoxanthine phosphoribosyltransferase gene of human fibroblasts: correlation with mutation spectra. Wei, D., Maher, V.M., McCormick, J.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy. Dovey, H.F., McKerrow, J.H., Aldritt, S.M., Wang, C.C. J. Biol. Chem. (1986) [Pubmed]
  7. A single amino acid substitution in the human and a bacterial hypoxanthine phosphoribosyltransferase modulates specificity for the binding of guanine. Lee, C.C., Craig, S.P., Eakin, A.E. Biochemistry (1998) [Pubmed]
  8. Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Guddat, L.W., Vos, S., Martin, J.L., Keough, D.T., de Jersey, J. Protein Sci. (2002) [Pubmed]
  9. Molecular cloning of genes involved in purine biosynthetic and salvage pathways of Salmonella typhimurium. O'Reilly, C., Turner, P.D., Smith-Keary, P.F., McConnell, D.J. Mol. Gen. Genet. (1984) [Pubmed]
  10. A Lactococcus lactis gene encodes a membrane protein with putative ATPase activity that is homologous to the essential Escherichia coli ftsH gene product. Nilsson, D., Lauridsen, A.A., Tomoyasu, T., Ogura, T. Microbiology (Reading, Engl.) (1994) [Pubmed]
  11. Cloning, expression and characterization of an unusual guanine phosphoribosyltransferase from Giardia lamblia. Sommer, J.M., Ma, H., Wang, C.C. Mol. Biochem. Parasitol. (1996) [Pubmed]
  12. High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase. Craig, S.P., Yuan, L., Kuntz, D.A., McKerrow, J.H., Wang, C.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  13. Development of a markerless genetic exchange method for Methanosarcina acetivorans C2A and its use in construction of new genetic tools for methanogenic archaea. Pritchett, M.A., Zhang, J.K., Metcalf, W.W. Appl. Environ. Microbiol. (2004) [Pubmed]
  14. Protection of Chinese hamster cells against the cytotoxic and mutagenic effects of alkylating agents by transfection of the Escherichia coli alkyltransferase gene and a truncated derivative. Fox, M., Brennand, J., Margison, G.P. Mutagenesis (1987) [Pubmed]
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