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Gene Review

LRPAP1  -  low density lipoprotein receptor-related...

Homo sapiens

Synonyms: A2MRAP, A2RAP, Alpha-2-MRAP, Alpha-2-macroglobulin receptor-associated protein, HBP44, ...
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Disease relevance of LRPAP1


High impact information on LRPAP1


Biological context of LRPAP1


Anatomical context of LRPAP1


Other interactions of LRPAP1

  • Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1) [11].
  • Three coding polymorphisms of LRP1 (exon 3, C766T; exon 14, A217V; and exon 39, D2080N), together with an insertion/deletion polymorphism within the first intron of lipoprotein receptor-associated protein (LRPAP1), have been identified [12].
  • A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease [9].

Analytical, diagnostic and therapeutic context of LRPAP1


  1. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. Van Leuven, F., Hilliker, C., Serneels, L., Umans, L., Overbergh, L., De Strooper, B., Fryns, J.P., Van den Berghe, H. Genomics (1995) [Pubmed]
  2. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. Striekland, D.K., Ashcom, J.D., Williams, S., Battey, F., Behre, E., McTigue, K., Battey, J.F., Argraves, W.S. J. Biol. Chem. (1991) [Pubmed]
  3. Heparin binding protein-44 (HBP-44)/receptor-associated protein (RAP)mediates cell-substratum adhesion of mouse NIH/3T3 cells through its binding to low density lipoprotein (LDL) receptor-related protein (LRP). Terada, H., Tsutsui, J., Sanada, J., Arima, T., Ozawa, M. Mol. Membr. Biol. (1997) [Pubmed]
  4. gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Orlando, R.A., Kerjaschki, D., Kurihara, H., Biemesderfer, D., Farquhar, M.G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. MR portography: preliminary comparison with CT portography and conventional MR imaging. Dravid, V.S., Shapiro, M.J., Mitchell, D.G., Outwater, E.K., Piccoli, C.W., Feld, R.I., Wechsler, R.J., Rosato, F.E. Journal of magnetic resonance imaging : JMRI. (1994) [Pubmed]
  6. Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) and other gene fragments to human chromosome 4p16.3 by direct cDNA selection. Jou, Y.S., Goold, R.D., Myers, R.M. Genomics (1994) [Pubmed]
  7. Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease. Dixit, M., Choudhuri, G., Keshri, L.J., Mittal, B. J. Gastroenterol. Hepatol. (2006) [Pubmed]
  8. Association of lipoprotein receptor, receptor-associated protein, and metabolizing enzyme gene polymorphisms with gallstone disease: A case-control study. Dixit, M., Choudhuri, G., Mittal, B. Hepatol. Res. (2006) [Pubmed]
  9. A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease. Schutte, D.L., Maas, M., Buckwalter, K.C. Research and theory for nursing practice. (2003) [Pubmed]
  10. Location of gp330/alpha 2-m receptor-associated protein (alpha 2-MRAP) and its binding sites in kidney: distribution of endogenous alpha 2-MRAP is modified by tissue processing. Abbate, M., Bachinsky, D., Zheng, G., Stamenkovic, I., McLaughlin, M., Niles, J.L., McCluskey, R.T., Brown, D. Eur. J. Cell Biol. (1993) [Pubmed]
  11. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). Korenberg, J.R., Argraves, K.M., Chen, X.N., Tran, H., Strickland, D.K., Argraves, W.S. Genomics (1994) [Pubmed]
  12. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. Cunningham, N., Laffan, M.A., Manning, R.A., O'Donnell, J.S. Blood Coagul. Fibrinolysis (2005) [Pubmed]
  13. Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation. Van Leuven, F., Thiry, E., Stas, L., Nelissen, B. Genomics (1998) [Pubmed]
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