Gene Review:
LRP2 - low density lipoprotein receptor-related...
Homo sapiens
Synonyms:
DBS, GP330, Glycoprotein 330, LRP-2, Low-density lipoprotein receptor-related protein 2, ...
Marinò,
Chiovato,
Mitsiades,
Latrofa,
Andrews,
Tseleni-Balafouta,
Collins,
Pinchera,
McCluskey,
Moestrup,
Schousboe,
Jacobsen,
Leheste,
Christensen,
Willnow,
Hussain,
Strickland,
Bakillah,
Biemesderfer,
Nagy,
DeGray,
Aronson,
Chen,
Saffitz,
Latour,
Schonfeld,
Nykjaer,
Fyfe,
Kozyraki,
Leheste,
Jacobsen,
Nielsen,
Verroust,
Aminoff,
de la Chapelle,
Moestrup,
Ray,
Gliemann,
Willnow,
Christensen,
Kozyraki,
- Anti-CD69 autoantibodies cross-react with low density lipoprotein receptor-related protein 2 in systemic autoimmune diseases. Yu, X., Matsui, T., Otsuka, M., Sekine, T., Yamamoto, K., Nishioka, K., Kato, T. J. Immunol. (2001)
- Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases. Ooka, S., Matsui, T., Nishioka, K., Kato, T. Arthritis Res. Ther. (2003)
- Megalin-mediated endocytosis of vitamin d binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. Rowling, M.J., Kemmis, C.M., Taffany, D.A., Welsh, J. J. Nutr. (2006)
- Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). Nykjaer, A., Fyfe, J.C., Kozyraki, R., Leheste, J.R., Jacobsen, C., Nielsen, M.S., Verroust, P.J., Aminoff, M., de la Chapelle, A., Moestrup, S.K., Ray, R., Gliemann, J., Willnow, T.E., Christensen, E.I. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Megalin and cubilin: multifunctional endocytic receptors. Christensen, E.I., Birn, H. Nat. Rev. Mol. Cell Biol. (2002)
- Truncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor. Chen, Z., Saffitz, J.E., Latour, M.A., Schonfeld, G. J. Clin. Invest. (1999)
- Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. Striekland, D.K., Ashcom, J.D., Williams, S., Battey, F., Behre, E., McTigue, K., Battey, J.F., Argraves, W.S. J. Biol. Chem. (1991)
- Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. Moestrup, S.K., Birn, H., Fischer, P.B., Petersen, C.M., Verroust, P.J., Sim, R.B., Christensen, E.I., Nexø, E. Proc. Natl. Acad. Sci. U.S.A. (1996)
- The mammalian low-density lipoprotein receptor family. Hussain, M.M., Strickland, D.K., Bakillah, A. Annu. Rev. Nutr. (1999)
- Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. Kounnas, M.Z., Loukinova, E.B., Stefansson, S., Harmony, J.A., Brewer, B.H., Strickland, D.K., Argraves, W.S. J. Biol. Chem. (1995)
- Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes. Andreasen, P.A., Sottrup-Jensen, L., Kjøller, L., Nykjaer, A., Moestrup, S.K., Petersen, C.M., Gliemann, J. FEBS Lett. (1994)
- beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin. Moestrup, S.K., Schousboe, I., Jacobsen, C., Leheste, J.R., Christensen, E.I., Willnow, T.E. J. Clin. Invest. (1998)
- The Heymann nephritis antigenic complex: megalin (gp330) and RAP. Farquhar, M.G., Saito, A., Kerjaschki, D., Orlando, R.A. J. Am. Soc. Nephrol. (1995)
- The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. Patrie, K.M., Drescher, A.J., Goyal, M., Wiggins, R.C., Margolis, B. J. Am. Soc. Nephrol. (2001)
- Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro. Kounnas, M.Z., Chappell, D.A., Strickland, D.K., Argraves, W.S. J. Biol. Chem. (1993)
- Circulating thyroglobulin transcytosed by thyroid cells in complexed with secretory components of its endocytic receptor megalin. Marinò, M., Chiovato, L., Mitsiades, N., Latrofa, F., Andrews, D., Tseleni-Balafouta, S., Collins, A.B., Pinchera, A., McCluskey, R.T. J. Clin. Endocrinol. Metab. (2000)
- Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule. Biemesderfer, D., Nagy, T., DeGray, B., Aronson, P.S. J. Biol. Chem. (1999)
- Cubilin, a multifunctional epithelial receptor: an overview. Kozyraki, R. J. Mol. Med. (2001)
- The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. Hvidberg, V., Jacobsen, C., Strong, R.K., Cowland, J.B., Moestrup, S.K., Borregaard, N. FEBS Lett. (2005)
- Cubilin and megalin in radiation-induced renal injury with labelled somatostatin analogues: are we just dealing with the kidney? Rolleman, E.J., Valkema, R., Melis, M., Krenning, E.P., Visser, T.J., de Jong, M. Eur. J. Nucl. Med. Mol. Imaging (2006)
- Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. Hammad, S.M., Ranganathan, S., Loukinova, E., Twal, W.O., Argraves, W.S. J. Biol. Chem. (1997)
- gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex. Stefansson, S., Kounnas, M.Z., Henkin, J., Mallampalli, R.K., Chappell, D.A., Strickland, D.K., Argraves, W.S. J. Cell. Sci. (1995)
- Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). Korenberg, J.R., Argraves, K.M., Chen, X.N., Tran, H., Strickland, D.K., Argraves, W.S. Genomics (1994)
- Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells. Wolff, N.A., Abouhamed, M., Verroust, P.J., Thévenod, F. J. Pharmacol. Exp. Ther. (2006)
- Degradation of urokinase plasminogen activator (UPA) in endometrial stromal cells requires both the UPA receptor and the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor. Casslén, B., Gustavsson, B., Angelin, B., Gåfvels, M. Mol. Hum. Reprod. (1998)