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Gene Review

B-G  -  MHC class II antigen

Gallus gallus

 
 
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Disease relevance of B-G

 

High impact information on B-G

 

Biological context of B-G

  • The chicken major histocompatibility complex (MHC) is commonly defined by serologic reactions of erythrocytes with antibodies specific to the highly polymorphic MHC class I (BF) and MHC class IV (BG) antigens [8].
  • The microsatellite marker LEI0258 is known to be physically located within the MHC, between the BG and BF regions [8].
  • The humoral response in another pair of recombinant haplotypes originating in 2 different White Leghorn chickens being BF21, BL21, BG15 (BR4) and BF15, BL15, BG21 (BR5) on the MHC locus indicated that the BG locus may perform an adjuvant effect on the antibody response as well [9].
  • In either case, the B-G (class IV) allele was recombined with both the B-F and B-L alleles of the opposite haplotype [10].
  • Graft survival time after pretreatment of recipients with CB blood could be prolonged by prior induction of neonatal tolerance to the B-G product; this could be done with injections of whole blood or of separated erythrocytes or leucocytes of line CC.R1 chickens (incompatible with CC recipients in the B-G region) [11].
 

Anatomical context of B-G

  • The humoral response of 1 pair of recombinants isolated from a Red Jungle Fowl (BW3 and BW4) being identical on BF and BG, but different on BL, indicated that part of the primary vaccine response was an MHC II restricted T-cell dependent response [9].
  • Since aberrant MHC-class II antigen expression could prove to be an epiphenomenon of virally afflicted TEC, we determined 2,5-oligoadenylate synthetase and 2,5-oligoadenylatepolymer cytosol levels in both chicken lines [12].
  • The primary cultures of TSC isolated from thymus mainly have consisted of epithelial cells which were polygonal in shape, possessed long processes and expressed MHC class II antigen [13].
 

Associations of B-G with chemical compounds

 

Analytical, diagnostic and therapeutic context of B-G

References

  1. Analysis of B-G and immune response genes in the Iowa State University S1 chicken line by hybridization of sperm deoxyribonucleic acid with a major histocompatibility complex class II probe. Pitcovski, J., Lamont, S.J., Nordskog, A.W., Warner, C.M. Poult. Sci. (1989) [Pubmed]
  2. B (MHC) antigen dependent modulation of GvH reactivity by neonatal thymectomy and alloimmunization. Plachý, J., Vilhelmová, M., Schulmannová, J., Karakoz, I. Folia Biol. (Praha) (1989) [Pubmed]
  3. Endothelial MHC class II antigen expression and endarteritis associated with Marek's disease virus infection in chickens. Kariuki Njenga, M., Dangler, C.A. Vet. Pathol. (1995) [Pubmed]
  4. Analysis of transcriptional and translational activities of Marek's disease (MD) virus genes in MD central nervous system lesions in chickens. Cho, K.O., Endoh, D., Onuma, M., Itakura, C. Avian Pathol. (1999) [Pubmed]
  5. Tolerance and autoimmunity to erythroid differentiation (B-G) major histocompatibility complex alloantigens of the chicken. Havele, C., Wegmann, T.G., Longenecker, B.M. J. Exp. Med. (1982) [Pubmed]
  6. Size polymorphism of chicken major histocompatibility complex-encoded B-G molecules is due to length variation in the cytoplasmic heptad repeat region. Kaufman, J., Salomonsen, J., Skjødt, K., Thorpe, D. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Antigen-presenting cell-T cell interaction in the chicken is MHC class II antigen restricted. Vainio, O., Veromaa, T., Eerola, E., Toivanen, P., Ratcliffe, M.J. J. Immunol. (1988) [Pubmed]
  8. Molecular genotype identification of the Gallus gallus major histocompatibility complex. Fulton, J.E., Juul-Madsen, H.R., Ashwell, C.M., McCarron, A.M., Arthur, J.A., O'Sullivan, N.P., Taylor, R.L. Immunogenetics (2006) [Pubmed]
  9. Immune response to a killed infectious bursal disease virus vaccine in inbred chicken lines with different major histocompatibility complex haplotypes. Juul-Madsen, H.R., Dalgaard, T.S., Røntved, C.M., Jensen, K.H., Bumstead, N. Poult. Sci. (2006) [Pubmed]
  10. Analysis of chickens for recombination within the MHC (B-complex). Skjødt, K., Koch, C., Crone, M., Simonsen, M. Tissue Antigens (1985) [Pubmed]
  11. Test of prolongation of skin graft survival by blood injections provides evidence for presence of a new histocompatibility locus in the B-G region of chicken MHC. Vilhelmová, M. Tissue Antigens (1987) [Pubmed]
  12. Genetically determined target organ susceptibility in the pathogenesis of spontaneous autoimmune thyroiditis: aberrant expression of MHC-class II antigens and the possible role of virus. Kühr, T., Hala, K., Dietrich, H., Herold, M., Wick, G. J. Autoimmun. (1994) [Pubmed]
  13. Effects of chicken thymic stromal cells on the growth and differentiation of thymocytes in vitro. Mukamoto, M., Okada, T., Kodama, H., Baba, T. Vet. Immunol. Immunopathol. (1999) [Pubmed]
  14. Cellular expression of MHC glycoproteins on erythrocytes from normal and aneuploid chickens. Delany, M.E., Briles, W.E., Briles, R.W., Dietert, R.R., Willand, E.M., Bloom, S.E. Dev. Comp. Immunol. (1987) [Pubmed]
  15. The chicken erythrocyte-specific MHC antigen. Characterization and purification of the B-G antigen by monoclonal antibodies. Salomonsen, J., Skjødt, K., Crone, M., Simonsen, M. Immunogenetics (1987) [Pubmed]
  16. Biochemical identification of B-F and B-G allelic variants of the chicken major histocompatibility complex. Hepkema, B.G., van der Poel, A., Grosfeld-Stulemeyer, M.C., Hensen, E.J. Anim. Genet. (1991) [Pubmed]
  17. Three new MHC haplotypes in broiler breeder chickens. Livant, E.J., Zheng, D., Johnson, L.W., Shi, W., Ewald, S.J. Anim. Genet. (2001) [Pubmed]
 
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