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Chemical Compound Review

triflate     trifluoromethanesulfonic acid

Synonyms: Trimsylate, tfmsa, HOTf, TfOH, PFC-MS, ...
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Disease relevance of trifluoromethanesulfonic acid


High impact information on trifluoromethanesulfonic acid


Biological context of trifluoromethanesulfonic acid


Anatomical context of trifluoromethanesulfonic acid


Associations of trifluoromethanesulfonic acid with other chemical compounds


Gene context of trifluoromethanesulfonic acid

  • MAb PANH3 raised against a synthetic peptide derived from the MG2 (MUC7) sequence reacted with the native molecule and stained a narrow smear of ca. 200,000 to 210,000 in Western blots of concentrated saliva and a lower-molecular-weight smear of trifluoromethanesulfonic-acid-treated MG2 [25].
  • PANH2 binding was increased by deglycosylation with trifluoromethanesulfonic acid as well as with subsequent periodate treatment, and was eliminated by pronase treatment, strongly suggesting that MAb PANH2 was directed to a peptide epitope of MG1 [25].
  • Assays for the detection of glycoconjugates (periodate oxidation, sialidase treatment, trifluoromethanesulfonic acid treatment) indicate that the hGH variant has carbohydrate moieties [26].
  • Studies on the deglycosylation of porcine submaxillary mucin and human tracheobronchial mucin indicate that this approach provides more efficient removal of carbohydrate and less peptide core degradation than a more vigorous (25 degrees C) treatment with TFMSA alone [27].
  • No binding occurred to the core protein of HSPG obtained after removal of HS with trifluoromethanesulfonic acid [28].

Analytical, diagnostic and therapeutic context of trifluoromethanesulfonic acid


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