Disease relevance of janB

• Although the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway is part of the antiviral response in arthropods such as Drosophila, here we show that white spot syndrome virus (WSSV) uses a shrimp STAT as a transcription factor to enhance viral gene expression in host cells [1].
• Pretreatment with hyperthermia did significantly increase the breakage and chromosome loss induced by 0.85-MeV fission neutrons from the JANUS biological research reactor in spermatozoa, early and late spermatids and spermatocytes [2].

Psychiatry related information on janB

• Drosophila carrying the X-linked mutation dunce (dnc) showed poor learning in a negative reinforcement olfactory conditioning paradigm (Dudai, Y., Y.-N. Jan, D. Byers, W.G. Quinn, and S. Benzer (1976) Proc. Natl. Acad. Sci. U.S.A. 73: 1684-1688) [3].

High impact information on janB

• Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population [4].
• The hop gene encodes a putative nonreceptor tyrosine kinase of the Janus kinase family, based on an internal duplication of the catalytic domain [5].
• With this approach, we discriminate and sort plasmatocytes, the major hemocyte subset, from lamellocytes, an activated subset present in gain-of-function mutants of the Janus kinase and Toll pathways [6].
• The 5' end of the janB mRNA mapped within the 3' untranslated region of the janA transcribed sequence [7].
• In mammals, the JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathway is activated in response to cytokines and growth factors to control blood cell development, proliferation and cell determination [8].

Biological context of janB

• A restriction survey of an additional 28 lines of D. simulans revealed strong linkage disequilibrium over the janA-janB region and identified six more alleles matching the rare haplotype [9].
• Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup [10].
• Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans [9].
• Data obtained from genomic and cDNA sequencing and from a combination of S1 mapping and primer extension experiments indicated a very unusual organization of this locus, which appeared to be composed of two partially overlapping genes, designated janA and janB [7].
• The genes janus (jan) A and B, and serendipity (sry) beta and delta are two pairs of duplicated genes that are adjacent to each other on the third chromosome of Drosophila melanogaster [11].

Anatomical context of janB

• The janB transcript was detected only in males, and its expression at the adult stage was restricted to germ line cells [7].
• The hemolymph-like HL3 saline(Stewart et al., 1994)and standard saline(Jan & Jan, 1976)are two widely used bathing solutions for physiological recordings at the Drosophila larval neuromuscular junction [12].
• In the Drosophila male germline, local activation of the Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway maintains stem cells; germline stem cells lacking Jak-STAT signaling differentiate into spermatogonia without self-renewal [13].

Associations of janB with chemical compounds

• The intracellular part of longer isoforms contained a proline-rich region defining a box1 motif for interaction with the Janus kinases [14].
• The Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT) pathway represents one such signalling cascade whose evolutionarily conserved roles include cell proliferation and haematopoiesis [15].

Analytical, diagnostic and therapeutic context of janB

• The hub specifically expresses Unpaired, a ligand activating the JAK-STAT (Janus kinase-signal transducer and activator of transcription) signaling cascade [16].

References