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Gene Review

IL12A  -  interleukin 12A (natural killer cell...

Felis catus

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Disease relevance of IL12A

  • These results suggest that the inhibitory effect of IL-12 on both virus replication and apoptosis has potential implications for the design of immunotherapy strategies using IL-12 in FIV infection [1].
  • Here we report the cloning and sequencing of feline IL-12, the expression of the p40-protein in E. coli and production of monoclonal antibodies [2].
  • In contrast, three of five kittens given FeLV DNA and IL-12 became persistently viraemic [3].
  • This adenoviral vector will be a useful tool to examine the effects of intra-tumoural IL-12 delivery in a spontaneously occurring feline soft tissue sarcoma model [4].
  • The interleukin-12 gene has been placed under control of a heat inducible promoter, human heat shock promoter 70b, with the intent of spatially and temporally controlling the expression of IL-12, thus limiting its toxicity [4].

High impact information on IL12A


Biological context of IL12A


Anatomical context of IL12A


Other interactions of IL12A

  • This study extends the data on IL-12 and provides new results on CpG motifs and IL-16 used as adjuvants in the FIV cat model [6].

Analytical, diagnostic and therapeutic context of IL12A


  1. Effect of interleukin-12 and interleukin-10 on the virus replication and apoptosis in T-cells infected with feline immunodeficiency virus. Mortola, E., Endo, Y., Mizuno, T., Ohno, K., Watari, T., Tsujimoto, H., Hasegawa, A. J. Vet. Med. Sci. (1998) [Pubmed]
  2. Nucleotide and predicted peptide sequence of feline interleukin-12 (IL-12). Fehr, D., Dean, G.A., Huder, J., Fan, Z., Huettner, S., Higgins, J.W., Pedersen, N.C., Lutz, H. DNA Seq. (1997) [Pubmed]
  3. A vector expressing feline mature IL-18 fused to IL-1beta antagonist protein signal sequence is an effective adjuvant to a DNA vaccine for feline leukaemia virus. O'Donovan, L.H., McMonagle, E.L., Taylor, S., Bain, D., Pacitti, A.M., Golder, M.C., McDonald, M., Hanlon, L., Onions, D.E., Argyle, D.J., Jarrett, O., Nicolson, L. Vaccine (2005) [Pubmed]
  4. Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. Siddiqui, F., Li, C.Y., Zhang, X., Larue, S.M., Dewhirst, M.W., Ullrich, R.L., Avery, P.R. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (2006) [Pubmed]
  5. Interleukin-12, dendritic cells, and the initiation of host-protective mechanisms against Toxoplasma gondii. Johnson, L.L., Sayles, P.C. J. Exp. Med. (1997) [Pubmed]
  6. Immunization of cats against feline immunodeficiency virus (FIV) infection by using minimalistic immunogenic defined gene expression vector vaccines expressing FIV gp140 alone or with feline interleukin-12 (IL-12), IL-16, or a CpG motif. Leutenegger, C.M., Boretti, F.S., Mislin, C.N., Flynn, J.N., Schroff, M., Habel, A., Junghans, C., Koenig-Merediz, S.A., Sigrist, B., Aubert, A., Pedersen, N.C., Wittig, B., Lutz, H. J. Virol. (2000) [Pubmed]
  7. Protection against feline immunodeficiency virus using replication defective proviral DNA vaccines with feline interleukin-12 and -18. Dunham, S.P., Flynn, J.N., Rigby, M.A., Macdonald, J., Bruce, J., Cannon, C., Golder, M.C., Hanlon, L., Harbour, D.A., Mackay, N.A., Spibey, N., Jarrett, O., Neil, J.C. Vaccine (2002) [Pubmed]
  8. A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. Siddiqui, F., Li, C.Y., Larue, S.M., Poulson, J.M., Avery, P.R., Pruitt, A.F., Zhang, X., Ullrich, R.L., Thrall, D.E., Dewhirst, M.W., Hauck, M.L. Mol. Cancer Ther. (2007) [Pubmed]
  9. Interleukin-12, interferon-gamma and interleukin-4 gene expression in cats infected with Toxoplasma gondii. Koyama, T., Omata, Y., Maki, Y., Toyoda, Y., Saito, A. J. Vet. Med. Sci. (1999) [Pubmed]
  10. Molecular cloning of cat interleukin-12. Schijns, V.E., Wierda, C.M., Vahlenkamp, T.W., Horzinek, M.C. Immunogenetics (1997) [Pubmed]
  11. Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB. Yoshimoto, T., Nagase, H., Ishida, T., Inoue, J., Nariuchi, H. Eur. J. Immunol. (1997) [Pubmed]
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