Gene Review:
Il12b - interleukin 12b
Mus musculus
Synonyms:
CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 p40, IL-12 subunit p40, IL-12B, ...
Cooper,
Kipnis,
Turner,
Magram,
Ferrante,
Orme,
Pahan,
Sheikh,
Liu,
Hilger,
McKinney,
Petro,
Cua,
Sherlock,
Chen,
Murphy,
Joyce,
Seymour,
Lucian,
To,
Kwan,
Churakova,
Zurawski,
Wiekowski,
Lira,
Gorman,
Kastelein,
Sedgwick,
Shiraki,
Aihara,
Kinouchi,
Takahashi,
Oki,
Noguchi,
Takahashi,
Miyazaki,
Shimosegawa,
Huaux,
Arras,
Tomasi,
Barbarin,
Delos,
Coutelier,
Vink,
Phan,
Renauld,
Lison,
Becher,
Durell,
Noelle,
Fulton,
Martin,
Redline,
Henry Boom,
- Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. Becher, B., Durell, B.G., Noelle, R.J. J. Clin. Invest. (2002)
- Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Murphy, T.L., Cleveland, M.G., Kulesza, P., Magram, J., Murphy, K.M. Mol. Cell. Biol. (1995)
- A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Huaux, F., Arras, M., Tomasi, D., Barbarin, V., Delos, M., Coutelier, J.P., Vink, A., Phan, S.H., Renauld, J.C., Lison, D. J. Immunol. (2002)
- Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. Cooper, A.M., Kipnis, A., Turner, J., Magram, J., Ferrante, J., Orme, I.M. J. Immunol. (2002)
- The human interferon alpha/beta receptor: characterization and molecular cloning. Novick, D., Cohen, B., Rubinstein, M. Cell (1994)
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Cua, D.J., Sherlock, J., Chen, Y., Murphy, C.A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., Zurawski, S., Wiekowski, M., Lira, S.A., Gorman, D., Kastelein, R.A., Sedgwick, J.D. Nature (2003)
- A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Sanjabi, S., Williams, K.J., Saccani, S., Zhou, L., Hoffmann, A., Ghosh, G., Gerondakis, S., Natoli, G., Smale, S.T. Genes Dev. (2005)
- Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Stark, M.A., Huo, Y., Burcin, T.L., Morris, M.A., Olson, T.S., Ley, K. Immunity (2005)
- CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Schulz, O., Edwards, A.D., Schito, M., Aliberti, J., Manickasingham, S., Sher, A., Reis e Sousa, C. Immunity (2000)
- Role of Toll-Like Receptor 9 in Legionella pneumophila-Induced Interleukin-12 p40 Production in Bone Marrow-Derived Dendritic Cells and Macrophages from Permissive and Nonpermissive Mice. Newton, C.A., Perkins, I., Widen, R.H., Friedman, H., Klein, T.W. Infect. Immun. (2007)
- Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Plevy, S.E., Gemberling, J.H., Hsu, S., Dorner, A.J., Smale, S.T. Mol. Cell. Biol. (1997)
- Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Alleva, D.G., Pavlovich, R.P., Grant, C., Kaser, S.B., Beller, D.I. Diabetes (2000)
- Schistosoma mansoni-infected mice show augmented hepatic fibrosis and selective inhibition of liver cytokine production after treatment with anti-NK1.1 antibodies. Asseman, C., Pancré, V., Quatennens, B., Auriault, C. Immunol. Lett. (1996)
- Soluble branched (1,4)-beta-D-glucans from Acetobacter species enhance antitumor activities against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response. Kamiryo, Y., Yajima, T., Saito, K., Nishimura, H., Fushimi, T., Ohshima, Y., Tsukamoto, Y., Naito, S., Yoshikai, Y. Int. J. Cancer (2005)
- Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A., Ozato, K. J. Exp. Med. (1997)
- Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. Zhu, C., Rao, K., Xiong, H., Gagnidze, K., Li, F., Horvath, C., Plevy, S. J. Biol. Chem. (2003)
- Inhibition of interleukin-12 p40 transcription and NF-kappaB activation by nitric oxide in murine macrophages and dendritic cells. Xiong, H., Zhu, C., Li, F., Hegazi, R., He, K., Babyatsky, M., Bauer, A.J., Plevy, S.E. J. Biol. Chem. (2004)
- Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter. Maruyama, S., Sumita, K., Shen, H., Kanoh, M., Xu, X., Sato, M., Matsumoto, M., Shinomiya, H., Asano, Y. J. Immunol. (2003)
- ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. Tsujimura, H., Tamura, T., Gongora, C., Aliberti, J., Reis e Sousa, C., Sher, A., Ozato, K. Blood (2003)
- The critical role of IL-12p40 in initiating, enhancing, and perpetuating pathogenic events in murine experimental autoimmune neuritis. Bao, L., Lindgren, J.U., van der Meide, P., Zhu, S., Ljunggren, H.G., Zhu, J. Brain Pathol. (2002)
- Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells. Pahan, K., Sheikh, F.G., Liu, X., Hilger, S., McKinney, M., Petro, T.M. J. Biol. Chem. (2001)
- Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. Pagenstecher, A., Lassmann, S., Carson, M.J., Kincaid, C.L., Stalder, A.K., Campbell, I.L. J. Immunol. (2000)
- Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Khan, N., Rahim, S.S., Boddupalli, C.S., Ghousunnissa, S., Padma, S., Pathak, N., Thiagarajan, D., Hasnain, S.E., Mukhopadhyay, S. Blood (2006)
- Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2. Rothe, H., O'Hara, R.M., Martin, S., Kolb, H. Diabetologia (1997)
- Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma. Haskó, G., Kuhel, D.G., Marton, A., Nemeth, Z.H., Deitch, E.A., Szabó, C. Shock (2000)
- Mechanisms of strain-dependent development of mast cells from mouse splenocytes. Hu, Z.Q., Zhao, W.H., Shimamura, T. Immunol. Cell Biol. (2006)
- Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-kappa B expression and binding to the IL-12 p40 promoter. Liu, J., Beller, D. J. Immunol. (2002)
- Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages. Jana, M., Dasgupta, S., Saha, R.N., Liu, X., Pahan, K. J. Neurochem. (2003)
- IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice. Shiraki, M., Aihara, H., Kinouchi, Y., Takahashi, S., Oki, M., Noguchi, M., Takahashi, K., Miyazaki, J., Shimosegawa, T. Lab. Invest. (2004)
- Signaling through CD40 ligand decreases CD80 expression on murine Langerhans cells and enhances IL-12 p40 production. Sugaya, M., Nakamura, K., Asahina, A., Fujita, H., Tada, Y., Torii, H., Tamaki, K. Biochem. Biophys. Res. Commun. (2005)
- Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor. Lawlor, K.E., Wong, P.K., Campbell, I.K., van Rooijen, N., Wicks, I.P. Arthritis Rheum. (2005)
- Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages. Peng, X., Mosser, D.M., Adler, M.W., Rogers, T.J., Meissler, J.J., Eisenstein, T.K. J. Leukoc. Biol. (2000)
- Intradermal delivery of IL-12 naked DNA induces systemic NK cell activation and Th1 response in vivo that is independent of endogenous IL-12 production. Watanabe, M., Fenton, R.G., Wigginton, J.M., McCormick, K.L., Volker, K.M., Fogler, W.E., Roessler, P.G., Wiltrout, R.H. J. Immunol. (1999)
- IL-12 production by central nervous system microglia is inhibited by astrocytes. Aloisi, F., Penna, G., Cerase, J., Menéndez Iglesias, B., Adorini, L. J. Immunol. (1997)
- Pulmonary immune responses during primary mycobacterium bovis- Calmette-Guerin bacillus infection in C57Bl/6 mice. Fulton, S.A., Martin, T.D., Redline, R.W., Henry Boom, W. Am. J. Respir. Cell Mol. Biol. (2000)
- Dendritic cells and the regulation of a granulomatous immune response in the lung. Iyonaga, K., McCarthy, K.M., Schneeberger, E.E. Am. J. Respir. Cell Mol. Biol. (2002)