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Gene Review

Scgb2b24  -  secretoglobin, family 2B, member 24

Rattus norvegicus

Synonyms: Abpbg3, Abpz
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Disease relevance of LOC494528

  • Rat 2 cells stably transformed by murine v-fms (pB5 cells) were infected with retroviruses containing a human cDNA encoding either a full-length human T-cell protein tyrosine phosphatase (TC.PTP) or a truncated form (delta C11.PTP) in which an 11-kDa carboxy-terminal extension had been removed [1].

High impact information on LOC494528

  • Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue [2].
  • The established rat thymic epithelial cell line IT-45 R1 produced a polypeptide that resolves as a single band in the region of 11 kDa on NaDodSO4/polyacrylamide gels [3].
  • Mimetic peptides corresponding to leucine-rich repeats 1-3, encompassed by a collagen-binding approximately 11-kDa cyanogen bromide fragment of decorin and leucine-rich repeats 4 and 5, previously shown to bind to collagen, were tested for their ability to inhibit collagen bead binding [4].
  • These results demonstrate that the particulate cGMP-dependent protein kinase mediates the phosphorylation of the 225-, 132-, and 11-kDa proteins [5].
  • The 11-kDa protein is phospholamban based on the characteristic shift in apparent Mr from 11,000 to 27,000 on heating at 37 degrees C rather than boiling prior to electrophoresis [5].

Biological context of LOC494528

  • Transfection of COS cells with LARFN5C-Fc cDNA resulted in expression of the predicted protein, and Western blot analysis verified expression of approximately 11 kDa LARFN5C protein in vivo and its developmental regulation [6].

Anatomical context of LOC494528

  • The estrone conjugating activity of guinea pig microsomes was similarly activated at lower doses of radiation and declined at higher doses (greater than or equal to 36 megarads), with a target size of 57 +/- 11 kDa [7].
  • After a 2-h incubation, PRL-like immunoreactivity in lactating mammary gland medium was composed of 23-, 14-, and 11-kDa forms in the following relative amounts: 65 +/- 9, 17 +/- 1, and 10 +/- 5%, respectively [8].
  • C3a exhibits potent chemotactic activity for rat neutrophils, and C3 beta c is a novel basic neutrophil chemoattractant with molecular mass of about 11 kDa, suggesting that both chemoattractants play a role in the neutrophil infiltration into inflammatory site of carrageenin-induced inflammation in rats [9].

Associations of LOC494528 with chemical compounds

  • By contrast, T3 promotes incorporation of label into a single major 11 kDa species: this incorporated label is somewhat acid-labile, and the incorporation is abolished by nicotinamide [10].
  • Further degradation of the 27 kDa fragment by means of formic acid cleavage at Asp-Pro bonds resulted initially in the formation of two non-immunoreactive fragments of 17 kDa and 11 kDa, indicating that the epitope for 5-B6 has to be localized around the chemical cleavage sites Asp507 and/or Asp510 [11].
  • The molecular mass of OR2DSH was determined to be 11 kDa, which is almost the same as those of other heparin derivatives such as 2-O-desulfated heparin (2DSH), 6-O-desulfated heparin (6DSH) and N-desulfated N-reacetylated heparin (NDSNAc-heparin) [12].
  • Down-regulated genes included various molecular chaperones, the 11-kDa diazepam binding inhibitor, cyclin D1, and mitochondrial aspartate aminotransferase [13].
  • Sodium dodecyl sulfate/gel electrophoresis of the protein produced in this way under non-reducing conditions revealed four protein bands of 18, 16, 14 and 11 kDa [14].

Other interactions of LOC494528

  • DFF40 is typically bound to the 45-kDa subunit of DFF (DFF45), and activation of DFF40 may occur as a result of caspase-3-mediated cleavage of DFF45 into 30- and 11-kDa fragments [15].
  • Peptide-N-glycosidase F, capable of removing all classes of N-linked oligosaccharides, produced 8 and 11 kDa decreases in NEP 1 and NEP 2, respectively [16].
  • Pronase-induced splitting off of a 11 kDa heme-containing fragment of cytochrome b5 did not affect IMP content [17].

Analytical, diagnostic and therapeutic context of LOC494528

  • On gel filtration, the apparent M(r) was 11 kDa [18].
  • The major component of the 11-22-kDa fraction, photolabelled in an ADP/Ca(2+)-sensitive manner, also migrated at 22 kDa on SDS/PAGE; a minor 11-kDa component was also detected [19].


  1. Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase. Zander, N.F., Cool, D.E., Diltz, C.D., Rohrschneider, L.R., Krebs, E.G., Fischer, E.H. Oncogene (1993) [Pubmed]
  2. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Chen, J., Zheng, X.F., Brown, E.J., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Thymotaxin: a thymic epithelial peptide chemotactic for T-cell precursors. Imhof, B.A., Deugnier, M.A., Girault, J.M., Champion, S., Damais, C., Itoh, T., Thiery, J.P. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  4. Collagen phagocytosis by fibroblasts is regulated by decorin. Bhide, V.M., Laschinger, C.A., Arora, P.D., Lee, W., Hakkinen, L., Larjava, H., Sodek, J., McCulloch, C.A. J. Biol. Chem. (2005) [Pubmed]
  5. Atrial natriuretic peptide-dependent phosphorylation of smooth muscle cell particulate fraction proteins is mediated by cGMP-dependent protein kinase. Sarcevic, B., Brookes, V., Martin, T.J., Kemp, B.E., Robinson, P.J. J. Biol. Chem. (1989) [Pubmed]
  6. Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. Yang, T., Bernabeu, R., Xie, Y., Zhang, J.S., Massa, S.M., Rempel, H.C., Longo, F.M. J. Neurosci. (2003) [Pubmed]
  7. In situ structural analysis of microsomal UDP-glucuronyltransferases by radiation inactivation. Vessey, D.A., Kempner, E.S. J. Biol. Chem. (1989) [Pubmed]
  8. Processing of rat prolactin by rat tissue explants and serum in vitro. Baldocchi, R.A., Tan, L., Nicoll, C.S. Endocrinology (1992) [Pubmed]
  9. Complement component C3-derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation. Nakagawa, H., Komorita, N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  10. The rapid response of isolated mitochondrial particles to 0.1 nM-tri-iodothyronine correlates with the ADP-ribosylation of a single inner-membrane protein. Hardy, D.L., Mowbray, J. Biochem. J. (1992) [Pubmed]
  11. Determination of the epitope for the inhibitory monoclonal antibody 5-B6 on the catalytic subunit of gastric Mg(2+)-dependent H(+)-transporting and K(+)-stimulated ATPase. Van Uem, T.J., Swarts, H.G., De Pont, J.J. Biochem. J. (1991) [Pubmed]
  12. Enhancement of neurite outgrowth-promoting activity by heparin derivatives in sodium chlorate-treated explant cultures of rat central neurons. Usuki, S., Kariya, Y., Rösner, H., Ishihara, M., Sakamoto, T., Masuda, H., Kyogashima, M. J. Biochem. (2003) [Pubmed]
  13. Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Rosen, M.B., Wilson, V.S., Schmid, J.E., Gray, L.E. Reprod. Toxicol. (2005) [Pubmed]
  14. Purification of water-soluble bone-inductive protein from bovine demineralized bone matrix. Yoshimura, Y., Hirano, A., Nishida, M., Kawada, J., Horisaka, Y., Okamoto, Y., Matsumoto, N., Yamashita, K., Takagi, T. Biol. Pharm. Bull. (1993) [Pubmed]
  15. Regional and temporal alterations in DNA fragmentation factor (DFF)-like proteins following experimental brain trauma in the rat. Zhang, C., Raghupathi, R., Saatman, K.E., LaPlaca, M.C., McIntosh, T.K. J. Neurochem. (1999) [Pubmed]
  16. Glycosylation variants of endopeptidase-24.11 ('enkephalinase'). Vida, T.A., Hersh, L.B. Neuropeptides (1992) [Pubmed]
  17. Ultrastructure of reconstituted rat liver microsomal membranes and cytochrome b5- or P-450-containing proteoliposomes. Borovyagin, V.L., Tarachovsky YuS, n.u.l.l., Kanaeva, I.P., Karyakin, A.V., Bachmanova, G.I., Archakov, A.I. J. Ultrastruct. Res. (1985) [Pubmed]
  18. In vitro evidence that an 11-kilodalton N-terminal fragment of proopiomelanocortin is a growth factor specifically stimulating the development of lactotrophs in rat pituitary during postnatal life. Tilemans, D., Andries, M., Proost, P., Devreese, B., Van Beeumen, J., Denef, C. Endocrinology (1994) [Pubmed]
  19. Evidence for the involvement of a membrane-associated cyclosporin-A-binding protein in the Ca(2+)-activated inner membrane pore of heart mitochondria. Andreeva, L., Tanveer, A., Crompton, M. Eur. J. Biochem. (1995) [Pubmed]
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