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Gene Review

Dmrt1  -  doublesex and mab-3 related transcription...

Mus musculus

Synonyms: Doublesex-and mab-3-related transcription factor 1
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High impact information on Dmrt1

  • Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation [1].
  • Such evidence is highly suggestive of a conserved role(s) for Dmrt1 in vertebrate sexual development, but there has been no functional analysis of this gene in any species [1].
  • Here we show that murine Dmrt1 is essential for postnatal testis differentiation, with mutant phenotypes similar to those caused by human chromosome 9p deletions that remove the gene [1].
  • Of seven mammalian DM domain genes, only Dmrt1 and Dmrt2 have been functionally analyzed [2].
  • Gata4 regulates testis expression of Dmrt1 [3].

Biological context of Dmrt1

  • Multiple alternative splicing of mouse Dmrt1 during gonadal differentiation [4].
  • These results provide new insight into roles of regulation at level of splicing of the Dmrt1 in governing sex differentiation [4].
  • Northern blot and real time fluorescent quantitative RT-PCR further indicated that the expression of Dmrt1 a was dominantly higher than those of Dmrt1 b, c, and d, although they showed a similar up and down pattern of expression during embryo development [4].
  • Dmrt1, a gene that contains the DM-domain (Doublesex/Mab-3 DNA-binding motif), is considered to be one of the essential genes involved in the testicular differentiation cascade in mammals, birds, reptiles, and fish [5].
  • In this study, we have successfully isolated a Dmrt1 homolog from the frog Rana rugosa testes cDNA library and examined its expression during gonadal differentiation and in sex-reversed gonads [5].

Anatomical context of Dmrt1


Other interactions of Dmrt1

  • Further transient-transfection assays of various mutant promoters established the functional relevance of the Gata4-response and unknown factor-response elements, while studies of Dmrt1 expression in 13.5 days postcoitum Fog2 null gonads supported the in vivo importance of Gata4's regulation [3].

Analytical, diagnostic and therapeutic context of Dmrt1


  1. Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Raymond, C.S., Murphy, M.W., O'Sullivan, M.G., Bardwell, V.J., Zarkower, D. Genes Dev. (2000) [Pubmed]
  2. Mice Mutant in the DM Domain Gene Dmrt4 Are Viable and Fertile but Have Polyovular Follicles. Balciuniene, J., Bardwell, V.J., Zarkower, D. Mol. Cell. Biol. (2006) [Pubmed]
  3. Gata4 regulates testis expression of Dmrt1. Lei, N., Heckert, L.L. Mol. Cell. Biol. (2004) [Pubmed]
  4. Multiple alternative splicing of mouse Dmrt1 during gonadal differentiation. Lu, H., Huang, X., Zhang, L., Guo, Y., Cheng, H., Zhou, R. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  5. The Dmrt1 expression in sex-reversed gonads of amphibians. Shibata, K., Takase, M., Nakamura, M. Gen. Comp. Endocrinol. (2002) [Pubmed]
  6. Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. Raymond, C.S., Kettlewell, J.R., Hirsch, B., Bardwell, V.J., Zarkower, D. Dev. Biol. (1999) [Pubmed]
  7. Molecular cloning of Dmrt1 and its expression in the gonad of Xenopus. Osawa, N., Oshima, Y., Nakamura, M. Zool. Sci. (2005) [Pubmed]
  8. Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells. Lei, N., Heckert, L.L. Biol. Reprod. (2002) [Pubmed]
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