Gene Review:
DMRT1 - doublesex and mab-3 related transcription...
Homo sapiens
Synonyms:
CT154, DM domain expressed in testis protein 1, DMT1, Doublesex-and mab-3-related transcription factor 1
Ounap,
Uibo,
Zordania,
Kiho,
Ilus,
Oiglane-Shlik,
Bartsch,
Looijenga,
Hersmus,
Gillis,
Pfundt,
Stoop,
van Gurp,
Veltman,
Beverloo,
van Drunen,
van Kessel,
Pera,
Schneider,
Summersgill,
Shipley,
McIntyre,
van der Spek,
Schoenmakers,
Oosterhuis,
Kramer,
Malkowski,
Mankad,
Theobald,
Pakstis,
Rogers,
El-Mogharbel,
Wakefield,
Deakin,
Tsend-Ayush,
Gr??tzner,
Alsop,
Ezaz,
Marshall Graves,
- A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators. Raymond, C.S., Parker, E.D., Kettlewell, J.R., Brown, L.G., Page, D.C., Kusz, K., Jaruzelska, J., Reinberg, Y., Flejter, W.L., Bardwell, V.J., Hirsch, B., Zarkower, D. Hum. Mol. Genet. (1999)
- Three patients with 9p deletions including DMRT1 and DMRT2: a girl with XY complement, bilateral ovotestes, and extreme growth retardation, and two XX females with normal pubertal development. Ounap, K., Uibo, O., Zordania, R., Kiho, L., Ilus, T., Oiglane-Shlik, E., Bartsch, O. Am. J. Med. Genet. A (2004)
- Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Looijenga, L.H., Hersmus, R., Gillis, A.J., Pfundt, R., Stoop, H.J., van Gurp, R.J., Veltman, J., Beverloo, H.B., van Drunen, E., van Kessel, A.G., Pera, R.R., Schneider, D.T., Summersgill, B., Shipley, J., McIntyre, A., van der Spek, P., Schoenmakers, E., Oosterhuis, J.W. Cancer Res. (2006)
- Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Wang, X., Li, G.J., Zheng, W. Brain Res. (2006)
- A novel R416C mutation in human DMT1 (SLC11A2) displays pleiotropic effects on function and causes microcytic anemia and hepatic iron overload. Lam-Yuk-Tseung, S., Camaschella, C., Iolascon, A., Gros, P. Blood Cells Mol. Dis. (2006)
- Complex chromosome re-arrangement 45,X,t(Y;9) in a girl with sex reversal and mental retardation. de Ravel, T.J., Fryns, J.P., Van Driessche, J., Vermeesch, J.R. Am. J. Med. Genet. A (2004)
- Evidence for evolutionary conservation of sex-determining genes. Raymond, C.S., Shamu, C.E., Shen, M.M., Seifert, K.J., Hirsch, B., Hodgkin, J., Zarkower, D. Nature (1998)
- High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma. Chen, Y.W., Hu, X.T., Liang, A.C., Au, W.Y., So, C.C., Wong, M.L., Shen, L., Tao, Q., Chu, K.M., Kwong, Y.L., Liang, R.H., Srivastava, G. Blood (2006)
- DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Pospisilova, D., Mims, M.P., Nemeth, E., Ganz, T., Prchal, J.T. Blood (2006)
- Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin-dependent inheritance of familial cerebral palsy. Lerer, I., Sagi, M., Meiner, V., Cohen, T., Zlotogora, J., Abeliovich, D. Hum. Mol. Genet. (2005)
- Magnetic resonance tagging and echocardiographic response to dobutamine and functional improvement after reperfused myocardial infarction. Kramer, C.M., Malkowski, M.J., Mankad, S., Theobald, T.M., Pakstis, D.L., Rogers, W.J. Am. Heart J. (2002)
- Sex-determining gene(s) on distal 9p: clinical and molecular studies in six cases. Muroya, K., Okuyama, T., Goishi, K., Ogiso, Y., Fukuda, S., Kameyama, J., Sato, H., Suzuki, Y., Terasaki, H., Gomyo, H., Wakui, K., Fukushima, Y., Ogata, T. J. Clin. Endocrinol. Metab. (2000)
- The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript. Ottolenghi, C., Veitia, R., Barbieri, M., Fellous, M., McElreavey, K. Genomics (2000)
- DMRT gene cluster analysis in the platypus: New insights into genomic organization and regulatory regions. El-Mogharbel, N., Wakefield, M., Deakin, J.E., Tsend-Ayush, E., Gr??tzner, F., Alsop, A., Ezaz, T., Marshall Graves, J.A. Genomics (2007)
- Sex-specific expression of an evolutionarily conserved male regulatory gene, DMRT1, in birds. Shan, Z., Nanda, I., Wang, Y., Schmid, M., Vortkamp, A., Haaf, T. Cytogenet. Cell Genet. (2000)
- Differential and spermatogenic cell-specific expression of DMRT1 during sex reversal in protogynous hermaphroditic groupers. Xia, W., Zhou, L., Yao, B., Li, C.J., Gui, J.F. Mol. Cell. Endocrinol. (2007)
- "Insects do not have sex hormones": a myth? De Loof, A., Huybrechts, R. Gen. Comp. Endocrinol. (1998)
- Small-Molecule Screening Identifies the Selanazal Drug Ebselen as a Potent Inhibitor of DMT1-Mediated Iron Uptake. Wetli, H.A., Buckett, P.D., Wessling-Resnick, M. Chem. Biol. (2006)
- Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells. Bannon, D.I., Abounader, R., Lees, P.S., Bressler, J.P. Am. J. Physiol., Cell Physiol. (2003)
- DMRT-1 expression during NEC8 human embryonic carcinoma cell differentiation. Koji, H., Yamada, A., Nagasawa, T., Gamou, S. Cancer Sci. (2006)
- Expression of Dmrt1 protein in developing and in sex-reversed gonads of amphibians. Aoyama, S., Shibata, K., Tokunaga, S., Takase, M., Matsui, K., Nakamura, M. Cytogenet. Genome Res. (2003)
- Belgrade rats display liver iron loading. Thompson, K., Molina, R.M., Brain, J.D., Wessling-Resnick, M. J. Nutr. (2006)