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Gene Review

ETV7  -  ets variant 7

Homo sapiens

Synonyms: ETS translocation variant 7, ETS-related protein Tel2, TEL-2, TEL2, TELB, ...
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Disease relevance of ETV7


Psychiatry related information on ETV7


High impact information on ETV7

  • Although both proteins are transcriptional inhibitors binding similar DNA recognition sequences, they have opposite biologic effects: TEL inhibits proliferation while TEL2 promotes it [2].
  • TEL2 is expressed in the hematopoietic system, and its expression is up-regulated in bone marrow samples of some patients with leukemia, suggesting a role in oncogenesis [2].
  • Treating mice receiving transplants with TEL2-expressing bone marrow with the chemical carcinogen N-ethyl-N-nitrosourea (ENU) resulted in significantly accelerated disease onset [2].
  • Together our data identify TEL2 as a bona fide oncogene, but leukemic transformation is dependent on secondary mutations [2].
  • Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies [1].

Biological context of ETV7

  • The TEL2 gene consists of 8 exons spanning approximately 21 kilobases (kb) in human chromosome 6p21 [3].
  • These results suggest that TEL2 may play an important role in hematopoiesis and oncogenesis [4].
  • In addition, these mutants blocked TEL2-mediated transcriptional repression of a synthetic promoter containing TEL2 binding sites [4].
  • PSE1 is immunologically similar to and shares amino acid sequence with a protein (TREF) which binds the human transferrin receptor (HTFR) promoter [5].
  • Given that Tel2p has been shown to bind to a variety of nucleic acid structures in vitro, we speculate that the RAD-5/CLK-2 checkpoint protein may act at sites of DNA damage, either as a sensor of DNA damage or to aid in the repair of damaged DNA [6].

Anatomical context of ETV7

  • In addition, forced expression of TEL2 but not TEL blocks vitamin D3-induced differentiation of U937 and HL60 myeloid cells [2].
  • Additionally, the TEL2 protein is capable of associating with itself and with TEL1 in doubly transfected Hela cells, and this interaction is mediated through the pointed (PNT) domain of TEL1 [3].
  • Overexpression of TEL2 in U937 cells inhibited differentiation induced by vitamin D3 [4].
  • An enhanced activity of the TEL-2 cell membrane, consisting of several thin thread-like projections either with or without an expanded termination, was involved with contacting the thymocytes [7].
  • Morphological study of thymus stromal cells (TEL-2 cell) which play a role in the elimination of double positive immature thymocytes by phagocytosis [7].

Associations of ETV7 with chemical compounds

  • The HD % (the percentage of high-density component, i.e., the percentage of homopolymer component) results obtained by CTREF (CRYSTAF in TREF mode) technique are used as the input data together with the respective FT-IR spectra for PLS analyses to establish a calibration curve [8].

Physical interactions of ETV7

  • DNA binding assays show that TEL2 can bind the same consensus DNA binding sequence recognized by TEL1/ETV6 [3].

Other interactions of ETV7

  • TEL2 is a member of the ETS family of transcription factors, which is highly similar to TEL1/ETV6 [4].
  • Therefore, one of the internal primers of each translocation (ABL-2, TEL-2, AF4-2) was labeled with a characteristic fluorescent dye, and an automatic fluorescence-based DNA fragment analysis was performed [9].
  • The ETS factor TEL2 is a hematopoietic oncoprotein [2].
  • In the eight patients with cytogenetic or cryptic 6p gains, we identified a common overrepresented region extending for 5-6 megabases from the TNF gene to the ETV-7 gene [10].

Analytical, diagnostic and therapeutic context of ETV7

  • For every session, index temperatures T90 (temperature attained at 90% of tumour related measurement points), cumulative minutes for T90 > Tref, tumour related power density (SAR: specific absorption rate, in W/kg) and the effective perfusion Weff (in ml/100 g min) were calculated [11].


  1. The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. Cardone, M., Kandilci, A., Carella, C., Nilsson, J.A., Brennan, J.A., Sirma, S., Ozbek, U., Boyd, K., Cleveland, J.L., Grosveld, G.C. Mol. Cell. Biol. (2005) [Pubmed]
  2. The ETS factor TEL2 is a hematopoietic oncoprotein. Carella, C., Potter, M., Bonten, J., Rehg, J.E., Neale, G., Grosveld, G.C. Blood (2006) [Pubmed]
  3. Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6. Potter, M.D., Buijs, A., Kreider, B., van Rompaey, L., Grosveld, G.C. Blood (2000) [Pubmed]
  4. TEL2, an ETS factor expressed in human leukemia, regulates monocytic differentiation of U937 Cells and blocks the inhibitory effect of TEL1 on ras-induced cellular transformation. Kawagoe, H., Potter, M., Ellis, J., Grosveld, G.C. Cancer Res. (2004) [Pubmed]
  5. Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter. Knuth, M.W., Gunderson, S.I., Thompson, N.E., Strasheim, L.A., Burgess, R.R. J. Biol. Chem. (1990) [Pubmed]
  6. C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Ahmed, S., Alpi, A., Hengartner, M.O., Gartner, A. Curr. Biol. (2001) [Pubmed]
  7. Morphological study of thymus stromal cells (TEL-2 cell) which play a role in the elimination of double positive immature thymocytes by phagocytosis. Kawabuchi, M., Nakamura, K., Hirata, K., Mori, K., Nakashima, M., Kishi, H., Islam, S., Chongjian, Z., Watanabe, T. Anat. Rec. (1996) [Pubmed]
  8. Determination of the percentage of homopolymer component in Ziegler/Natta catalyst linear low-density polyethylene resins using high-temperature cell Fourier transform infrared and partial least squares quantitative analysis technique. Cossar, M., Teh, J., Kivisto, A., Mackenzie, J. Applied spectroscopy. (2005) [Pubmed]
  9. Multiplex PCR--a rapid screening method for detection of gene rearrangements in childhood acute lymphoblastic leukemia. Viehmann, S., Borkhardt, A., Lampert, F., Harbott, J. Ann. Hematol. (1999) [Pubmed]
  10. Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic syndrome and acute myeloid leukemia. La Starza, R., Aventin, A., Matteucci, C., Crescenzi, B., Romoli, S., Testoni, N., Pierini, V., Ciolli, S., Sambani, C., Locasciulli, A., Di Bona, E., Lafage-Pochitaloff, M., Martelli, M.F., Marynen, P., Mecucci, C. Leukemia (2006) [Pubmed]
  11. Temperature data and specific absorption rates in pelvic tumours: predictive factors and correlations. Tilly, W., Wust, P., Rau, B., Harder, C., Gellermann, J., Schlag, P., Budach, V., Felix, R. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (2001) [Pubmed]
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