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BRIX1  -  BRX1, biogenesis of ribosomes, homolog (S....

Homo sapiens

Synonyms: BRIX, BRX1, biogenesis of ribosomes, BXDC2, Brix domain-containing protein 2, FLJ11100, ...
 
 
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Disease relevance of BXDC2

  • 1-MCP-treated plums were firmer with lower weight loss, reduced degrees Brix/titratable acidity ratios, and lower color changes during cold storage and subsequent shelf life at 20 degrees C than controls [1].
  • Apple juice concentrate (AJC; 70 degree brix) was diluted into culture medium of SH-SY-5Y human neuroblastoma cells that had been differentiated for 7 days with 5 microM retinoic acid concurrent with the addition of 20 microM Abeta [2].
 

High impact information on BXDC2

  • The Brix domain protein family -- a key to the ribosomal biogenesis pathway [3]?
  • Gadolinium enhancement was analyzed using the Brix pharmacokinetic model to obtain the parameters amplitude and rate of contrast enhancement [4].
  • Increased Brix in ripe fruit was shown to be the result of increased sucrose and glucose, with a more minor contribution from aspartate and alanine [5].
  • Particularly striking was the co-ordinated up-regulation of enzymes of sucrose mobilization and respiration that occurred only in the two lines with the highest Brix increase [6].
  • The Brix values of polymeric diet had a linear additive relationship with the diet formula concentration at various pHs, temperatures, and in the gastric juice [7].
 

Biological context of BXDC2

 

Anatomical context of BXDC2

  • Exudates (agave juice) from a tequila company were collected periodically, and color, Brix, fructose concentration, and reducing sugars were determined as inulin breakdown took place [10].
 

Associations of BXDC2 with chemical compounds

  • The detection limit of patulin in single strength apple juice at a sugar content of 11.2 degrees Brix was lower than 5 micrograms/l. Patulin was detected in all of the samples analyzed, at concentrations ranging from 7 to 375 micrograms/l. Of the samples, 43.5% were found to exceed a patulin contamination level of 50 microgram/l [11].
  • Three types of activated carbon (NORIT SA 4, NORIT SX 4 and NORIT CA 1) were investigated for their ability to reduce patulin levels in apple juice at various Brix levels and temperatures [12].
  • Increments in color, Brix, and reducing sugars were observed as a function of time, but a decrease in fructose concentration was found [10].
  • Treatment and storage had a minimal effect on pH (range, 3.96 to 4.02), soluble solids (range, 11.8 to 12.9 degrees Brix), and total acidity (range, 0.20 to 0.23% malic acid), which are important for apple flavor [13].
  • Repeatability and reproducibility coefficients of variation ranged from 1.0 to 3.5% and 7.7 to 11.7%, respectively, within the range of 26 to 188 mg D-malic acid/100 mL of 12 Brix apple juice [14].
 

Analytical, diagnostic and therapeutic context of BXDC2

  • Several tomato lines carrying defined introgressions from S. pennellii in a S. lycopersicum background produce fruit with elevated Brix, a refractive index measure of soluble solids [6].
  • Determination of total nitrogen content, pH, density, refractive index, and brix in Thai fish sauces and their classification by near-infrared spectroscopy with searching combination moving window partial least squares [15].
  • Berries were sampled at maturity (>19 Brix) for determination of skin and/or pulp chemical and metabolic profiles based on (1) chemical and physicochemical measurement of minerals (N, P, K, Ca, Mg), (2) untargeted 1H NMR metabolic fingerprints, and HPLC targeted analyses of (3) amino acids and (4) phenolics [16].
  • The alginate-oil gels were immersed in 60 degrees Brix sucrose solution for various periods, before freeze-drying [17].
  • Gas chromatography was used to determine sucrose losses as Delta%glucose/%sucrose ratios on a degrees Brix basis [18].

References

  1. 1-methylcyclopropene increases storability and shelf life in climacteric and nonclimacteric plums. Martínez-Romero, D., Dupille, E., Guillén, F., Valverde, J.M., Serrano, M., Valero, D. J. Agric. Food Chem. (2003) [Pubmed]
  2. Apple juice prevents oxidative stress induced by amyloid-beta in culture. Ortiz, D., Shea, T.B. J. Alzheimers Dis. (2004) [Pubmed]
  3. The Brix domain protein family -- a key to the ribosomal biogenesis pathway? Eisenhaber, F., Wechselberger, C., Kreil, G. Trends Biochem. Sci. (2001) [Pubmed]
  4. Prediction of radiotherapy outcome using dynamic contrast enhanced MRI of carcinoma of the cervix. Loncaster, J.A., Carrington, B.M., Sykes, J.R., Jones, A.P., Todd, S.M., Cooper, R., Buckley, D.L., Davidson, S.E., Logue, J.P., Hunter, R.D., West, C.M. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  5. Fruit carbohydrate metabolism in an introgression line of tomato with increased fruit soluble solids. Baxter, C.J., Carrari, F., Bauke, A., Overy, S., Hill, S.A., Quick, P.W., Fernie, A.R., Sweetlove, L.J. Plant Cell Physiol. (2005) [Pubmed]
  6. Comparison of changes in fruit gene expression in tomato introgression lines provides evidence of genome-wide transcriptional changes and reveals links to mapped QTLs and described traits. Baxter, C.J., Sabar, M., Quick, W.P., Sweetlove, L.J. J. Exp. Bot. (2005) [Pubmed]
  7. Use of the refractometer as a tool to monitor dietary formula concentration in gastric juice. Chang, W.K., Chen, M.Z., Chao, Y.C. Clinical nutrition (Edinburgh, Scotland) (2002) [Pubmed]
  8. Brix from xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. Kaser, A., Bogengruber, E., Hallegger, M., Doppler, E., Lepperdinger, G., Jantsch, M., Breitenbach, M., Kreil, G. Biol. Chem. (2001) [Pubmed]
  9. Monitoring bolus nasogastric tube feeding by the Brix value determination and residual volume measurement of gastric contents. Chang, W.K., McClave, S.A., Lee, M.S., Chao, Y.C. JPEN. Journal of parenteral and enteral nutrition. (2004) [Pubmed]
  10. Generation of Maillard compounds from inulin during the thermal processing of Agave tequilana Weber Var. azul. Mancilla-Margalli, N.A., López, M.G. J. Agric. Food Chem. (2002) [Pubmed]
  11. Incidence of patulin in apple juice concentrates produced in Turkey. Gökmen, V., Acar, J. Journal of chromatography. A. (1998) [Pubmed]
  12. The reduction of patulin in apple juice by three different types of activated carbon. Leggott, N.L., Shephard, G.S., Stockenström, S., Staal, E., van Schatkwyk, D.J. Food additives and contaminants. (2001) [Pubmed]
  13. Consumer acceptance of raw apples treated with an antibacterial solution designed for home use. McWatters, K.H., Doyle, M.P., Walker, S.L., Rimal, A.P., Venkitanarayanan, K. J. Food Prot. (2002) [Pubmed]
  14. Determination of D-malic acid in apple juice by liquid chromatography: collaborative study. Eisele, T.A. Journal of AOAC International. (1996) [Pubmed]
  15. Determination of total nitrogen content, pH, density, refractive index, and brix in Thai fish sauces and their classification by near-infrared spectroscopy with searching combination moving window partial least squares. Ritthiruangdej, P., Kasemsumran, S., Suwonsichon, T., Haruthaithanasan, V., Thanapase, W., Ozaki, Y. The Analyst. (2005) [Pubmed]
  16. Microclimate influence on mineral and metabolic profiles of grape berries. Pereira, G.E., Gaudillere, J.P., Pieri, P., Hilbert, G., Maucourt, M., Deborde, C., Moing, A., Rolin, D. J. Agric. Food Chem. (2006) [Pubmed]
  17. Oxidation of encapsulated oil in tailor-made cellular solid. Rassis, D., Nussinovitch, A., Saguy, I.S. J. Agric. Food Chem. (2000) [Pubmed]
  18. Minimization of seasonal sucrose losses across Robert's-type evaporators in raw sugar manufacture by pH optimization. Eggleston, G., Monge, A. J. Agric. Food Chem. (2005) [Pubmed]
 
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