Disease relevance of CNO

• The majority of the Down syndrome fetuses had CRL, FL and CNO values within the range of those for normal age-matched fetuses [1].
• Results of analysis of variance (ANOVA) of central obesity status (CNO = no, CO = yes) and BMI (BMI tertiles used as a categorical variable) with these metabolic variables revealed that CO status had a significant effect (p < 0.05) on TC, VLDL-C, FPG and FTG [2].

Psychiatry related information on CNO

• CNO and CEO decision-making patterns and compatability: Part 2, Using the MBTI [3].

High impact information on CNO

• We performed mutation screening of patients with HPS and failed to identify any CNO defects [4].
• Levels of globin carbamylation of 0.5 moles CNO/mole hemoglobin, shown to be clinically effective in prolonging the life span of sickle erythrocytes, are obtained under these conditions and reach maximal levels after only 30 min of incubation [5].
• Red blood cells exposed to cyanate (CNO) in vitro have a concentration-dependent decreased cell survival time associated with an inhibition of the ability of the cell membrane to synthesize lipids [5].
• The values of K1K2 from kinetics are in good agreement with those obtained from spectral and [O2] determinations of equilibrated mixtures of Hr, CNO-, and O2 [6].
• Impairment of this arm of neutrophil bactericidal activity by CNO- formed from urea may be one factor in the risk of urinary-tract infection associated with urinary stasis and perhaps in the generalized increase in susceptibility to infection in uraemic patients [7].

Biological context of CNO

• In the former case it has been shown that "metal poisons" such as CN- and CNO- are not directly coordinated to the active site Zn(II) ion whereas spectroscopic studies indicate otherwise [8].
• During the same exhalation, ENO(b/o) was compared to CNO at multiple sites in the airway as the catheter was progressively withdrawn [9].
• These stages are related partly to general parameters of fetal development, such as M age (menstrual age), CRL (crown-rump length), CNO (composite number of ossified bones in hand and foot) and partly to stages in the skeletal development of the symphysis menti (SM I to SM V) [10].

Anatomical context of CNO

• We have explored the possibility that CNO- might be one of the unknown substances responsible for the reported impairment, by urine and uraemic plasma, of neutrophil oxidative metabolism (especially as measured by luminol-enhanced chemiluminescence) [7].
• Cyanate (CNO-) forms spontaneously in solutions containing urea, and is present in urine and the body fluids of uraemic patients [7].
• As the catheter was withdrawn, mean CNO concentration progressively increased both in absolute values and as a proportion of ENO(b/o), until in the oropharynx, it was 96.1 +/- 5.2% ENO(b/o) [9].
• A similar mechanism of cation is proposed for some other inhibitors of gastric acid secretion, e.g. nitrite (NO2-), cyanate (CNO-) and NH4+ [11].
• The material available did not justify a description of skeletal development of the maxilla as a function of CRL or CNO [12].

Associations of CNO with chemical compounds

• The larger univalent anions such as HCO3-, Br-, Cl-, NO3-, CNO- and I- seemed most effective, whereas the bivalent anion SO42- was relatively ineffective at 0.1 M, as were acetate and formate [13].
• The heterotrophic and autotrophic alkaliphiles that grew with thiocyanate as an N source possessed a relatively high level of cyanase activity which converted cyanate (CNO-) to ammonia and CO2 [14].
• Functional groups imaged by negative ion TOF-SIMS on (111) faces of the octahedral platelets were predominantly Cl and CN, with smaller amounts of C(2)H and CNO [15].
• Our results show that the product P1 (CO2 + CNO) is the major product with absolute yield, while the product P4 (2CO + NO) is the minor product with less abundance [16].
• Our data indicate that CNO quenches selectively one or two tryptophan residue(s) in the active site [17].

Analytical, diagnostic and therapeutic context of CNO

• The crown-rump length (CRL), foot length (FL) and number of ossified bones in the hand and foot (CNO) were recorded [1].

References