The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CCDC88A  -  coiled-coil domain containing 88A

Homo sapiens

Synonyms: APE, Akt phosphorylation enhancer, Coiled-coil domain-containing protein 88A, FLJ10392, G alpha-interacting vesicle-associated protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of KIAA1212

  • Analysis using clinical stool specimens revealed that the present system was capable of detecting SaV GI, GII, GIV, and GV sequences, and no cross-reactivity was observed against other enteric viruses, including norovirus (NoV), rotavirus, astrovirus, and adenovirus [1].
  • In a prospective work, we have studied the non-polio enterovirus (NPEV) excretion in spot urine and stools by four appropriate cell cultures, in four different groups: 20 exposed controls (GI), 88 patients with renal biopsy 'proven GN' (GII), 38 cases with 'proven nonGN' (GIII), and 9 with 'probable nonGN' (GIV) [2].

High impact information on KIAA1212

  • Sequence analysis of the T-20 resistant domain (a.a. 547-549, GIV) revealed that 99% of the specimens (149 of 150) carried a T-20 sensitive genotype [3].
  • While no mutations were found within a highly conserved 3-amino-acid sequence (GIV) known to be critical for fusion at baseline, after 14 days of therapy, virus from one patient in the 30-mg dose group (30-1) developed a mutation in this motif, specifically an aspartic acid (D) substitution for glycine (G) at position 36 [4].
  • The alignment of the SaV full-length ORF1 amino acid sequences indicated that the dipeptides used for the cleavage sites were either E or Q at the P1 position and A, G or S at the P1' position, which were conserved in the GI, GII, GIII, GIV and GV SaV ORF1 polyprotein [5].
  • Ultrastructural studies reveal that expression of the C-terminal HkRP1 domain causes an accumulation of internal membranes with an electron-dense coat [6].
  • We propose that HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains [6].

Biological context of KIAA1212

  • The reactivity was confirmed with SaV GI, GII, GIV, and GV control plasmids, and the efficiency ranged from 2.5 x 10(7) to 2.5 x 10(1) copies per tube [1].
  • Among the 184 strains studied, no amino acid mutation was found in the highly conserved three amino acid motif at codons 36-38 (GIV) that are important determinants of viral susceptibility to enfuvirtide [7].
  • GIII and IV exhibited statistically significant lower percentages of cell viability: GIV only at the 0 h experimental time, whereas in GIII this viability markedly diminished reaching values of 10% by 12 h [8].

Anatomical context of KIAA1212

  • Girdin (GIRDers of actIN filament, also reported as APE, GIV, or HkRP1) is a novel protein expressed ubiquitously in mammals and was recently identified as a binding partner of the serine/threonine kinase Akt [9].
  • From January 1995 to July 1996, the authors used Mitek GIV titanium anchors to treat seven patients with acute rupture of the Achilles tendon (four men, three women; average age 52.42 years; range, 33-62 years) [10].

Associations of KIAA1212 with chemical compounds

  • The patients of GII, GIIII and GIV when using MT presented amelioration of sex symptoms, mainly satisfaction and desire (p<0.01); however, GIII at T1 (1.3+/-0.3) presented similar problem score results as compared to GIII at T2 (1.5+/-0.6) [11].
  • The experimental groups were GI (control) no sodium alendronate, and GII, GIII, and GIV with sodium alendronate at the concentrations of 10(-5), 10(-6), and 10(-7) M, respectively [12].
  • RESULTS: Teicoplanin release in the calcium sulfate powder added groups (GIII and GIV) was higher than that of GII [13].
  • Eighty-eight samples of metallic supported feldspathic porcelain were randomly divided into four groups according to their surface preparation as follows: the porcelain was maintained intact (GI), roughened with a diamond bur (GII), etched with 10% hydrofluoric acid (GIII), or sandblasted with aluminum oxide (GIV) [14].
  • Groups GIII and GIV had final irrigation with EDTA-T and citric acid, respectively, plus an association of irrigating solution and Er:YAG laser [15].

Analytical, diagnostic and therapeutic context of KIAA1212

  • Procedures were also categorized into four different groups: GI, total abdominal colectomies; GII, segmental resections; GIII, diverting procedures; GIV, others (abdominoperineal resection, Hartmann's creation or closure, anterior resection, and rectopexy) [16].
  • A significant improvement in change of cough scores was found in end of intervention (2-3 months) in those receiving PPI with a standardised mean difference of -0.41 (95%CI -0.75, -0.07) using GIV analysis on cross over trials [17].
  • No fibers were added to group I (GI, control group); acrylic stain (AS) was added to GII and GIII in concentrations of 0.5 and 1.5% w/w, respectively; acrylic fibers (AF) were added to groups GIV and GV in concentrations of 0.5 and 1.5% w/w, respectively [18].
  • The methods used were GI, visual inspection; GII, tactile inspection (explorer probe); GIII, conventional radiographic exam; GIV, digital radiographic exam (Digora for Windows 1.51 and 1.51N, SoredexOrion Co.); GV, low-intensity laser for diagnosis (DIAGNOdent, KaVo, Germany); and GVI, histological inspection [19].


  1. Detection of human sapovirus by real-time reverse transcription-polymerase chain reaction. Oka, T., Katayama, K., Hansman, G.S., Kageyama, T., Ogawa, S., Wu, F.T., White, P.A., Takeda, N. J. Med. Virol. (2006) [Pubmed]
  2. Human glomerulonephritis and persistent non-polio enterovirus infection. Berthoux, F.C., Gaudin, O.G., Sterczinski, O., Granouillet, R., Genin, C., Pozetto, B., Laurent, B., Sabatier, J.C., Gonthier, R. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association. (1980) [Pubmed]
  3. Variability of critical epitopes within HIV-1 heptad repeat domains for selected entry inhibitors in HIV-infected populations worldwide [corrected]. Hanna, S.L., Yang, C., Owen, S.M., Lal, R.B. AIDS (2002) [Pubmed]
  4. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Wei, X., Decker, J.M., Liu, H., Zhang, Z., Arani, R.B., Kilby, J.M., Saag, M.S., Wu, X., Shaw, G.M., Kappes, J.C. Antimicrob. Agents Chemother. (2002) [Pubmed]
  5. Identification of the cleavage sites of sapovirus open reading frame 1 polyprotein. Oka, T., Yamamoto, M., Katayama, K., Hansman, G.S., Ogawa, S., Miyamura, T., Takeda, N. J. Gen. Virol. (2006) [Pubmed]
  6. A novel hook-related protein family and the characterization of hook-related protein 1. Simpson, F., Martin, S., Evans, T.M., Kerr, M., James, D.E., Parton, R.G., Teasdale, R.D., Wicking, C. Traffic (2005) [Pubmed]
  7. Enfuvirtide binding domain is highly conserved in non-B HIV type 1 strains from Cameroon, West Central Africa. Aghokeng, A.F., Ewane, L., Awazi, B., Nanfack, A., Delaporte, E., Zekeng, L., Peeters, M. AIDS Res. Hum. Retroviruses (2005) [Pubmed]
  8. Cytotoxicity of substances leached or dissolved from pulp capping materials. Cavalcanti, B.N., Rode, S.M., Marques, M.M. International endodontic journal. (2005) [Pubmed]
  9. Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the akt and wnt signaling pathways. Enomoto, A., Ping, J., Takahashi, M. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  10. Titanium anchors for the repair of distal Achilles tendon ruptures: preliminary report of a new surgical technique. Maniscalco, P., Bertone, C., Bonci, E., Donelli, L., Pagliantini, L. The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons. (1998) [Pubmed]
  11. The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms. de Paula, F.J., Soares, J.M., Haidar, M.A., Lima, G.R., Baracat, E.C. Maturitas (2007) [Pubmed]
  12. Cytotoxicity evaluation of sodium alendronate on cultured human periodontal ligament fibroblasts. Correia, V.d.e. .F., Caldeira, C.L., Marques, M.M. Dental traumatology : official publication of International Association for Dental Traumatology. (2006) [Pubmed]
  13. Elution characteristics and mechanical properties of calcium sulfate-loaded bone cement containing teicoplanin. Tuzuner, T., Uygur, I., Sencan, I., Haklar, U., Oktas, B., Ozdemir, D. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (2007) [Pubmed]
  14. Bonding brackets to porcelain--in vitro study. Sant'Anna, E.F., Monnerat, M.E., Chevitarese, O., Stuani, M.B. Brazilian dental journal. (2002) [Pubmed]
  15. In vitro evaluation of the effects of the interaction between irrigating solutions, intracanal medication and Er:YAG laser in dentin permeability of the endodontic system. Rald, D.P., Lage-Marques, J.L. Pesquisa odontológica brasileira = Brazilian oral research. (2003) [Pubmed]
  16. Intraoperative laparoscopic complications. Are we getting better? Agachan, F., Joo, J.S., Weiss, E.G., Wexner, S.D. Dis. Colon Rectum (1996) [Pubmed]
  17. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Chang, A.B., Lasserson, T.J., Gaffney, J., Connor, F.L., Garske, L.A. Cochrane database of systematic reviews (Online) (2006) [Pubmed]
  18. Effect of intrinsic pigmentation on the flexural strength of a microwave-cured acrylic resin. Silva, F.A., Silva, T.B., Rached, R.N., Del Bel Cury, A.A. Brazilian dental journal. (2002) [Pubmed]
  19. A comparative in vitro study to diagnose decayed dental tissue using different methods. Lizarelli, R.F., Bregagnolo, J.C., Lizarelli, R.Z., Palhares, J.M., Villa, G.E. Photomedicine and laser surgery. (2004) [Pubmed]
WikiGenes - Universities