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MeSH Review


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Disease relevance of Colectomy


High impact information on Colectomy

  • Two patients who had an initial response to neostigmine required colonoscopic decompression for recurrence of colonic distention; one eventually underwent subtotal colectomy [6].
  • Failure to respond to therapy resulted in colectomy, but some patients in the placebo group who had no response and no urgent need for surgery were subsequently treated with cyclosporine [7].
  • While in the hospital, patients assigned to LAC required fewer days of both parenteral analgesics compared with patients assigned to open colectomy (mean [median], 3.2 [3] vs 4.0 [4] days; P<.001) and oral analgesics (mean [median], 1.9 [1] vs 2.2 [2] days; P =.03) [8].
  • Colectomy specimens from five patients were assayed for N-myristoyltransferase activity [9].
  • Activated-carbon-oriented laparoscopic colectomy [10].

Chemical compound and disease context of Colectomy


Biological context of Colectomy


Anatomical context of Colectomy

  • Bile obtained from the gallbladder of 18 FAP patients immediately before colectomy, and from 18 control patients, was incubated with salmon sperm DNA in solution at 37 degrees C for 1 h, after which the purified DNA was analysed for DNA adducts, using the nuclease P1 method of 32P-postlabelling [21].
  • We correlated results with regional lymph node status and tumor stage, identified in subsequent colectomy specimens. bcl-2 and p53 protein expression were demonstrated by immunohistochemical methods, using formalin-fixed, paraffin-embedded biopsy tissues [22].
  • METHODS: Twenty-four pigs were randomized into the following four groups, based on the method for obtaining surgical exposure while a colectomy or laparoscopic-assisted colectomy was performed: Open surgery (n = 6), CO2 pneumoperitoneum (n = 6), Helium pneumoperitoneum (n = 6), and abdominal wall Lifter (n = 6) [23].
  • PURPOSE: The recent introduction of the immune suppressor cyclosporin for treatment of steroid-refractory ulcerative colitis has required surgeons to perform a colectomy in those patients who eventually fail this rescue treatment, thus raising questions as to the safety of surgery as performed in patients with a heavily manipulated immune system [24].
  • Gastric acid secretion (retention, basic, and stimulated) was studied, together with serum gastrin, pentagastrin, and pepsinogen, in patients before colectomy and after having had the pelvic pouch functioning for 12 months [25].

Associations of Colectomy with chemical compounds

  • The trial was completed either when the prednisone was reduced to 10 mg/day or when the patient came to colectomy [26].
  • Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis [27].
  • A significant increase in the molar percentage of cholesterol and a decrease in that of total bile acid associated with significantly decreased secondary bile acids (p < 0.05) were observed in the post colectomy group [28].
  • Five patients treated with metronidazole and six with placebo had no improvement and all proceeded to urgent colectomy with no operative mortality [29].
  • The aim of this study was to evaluate, in a prospective, randomized, double-blind fashion, the efficacy of a short perioperative course compared to an extended postoperative course of intravenous antibiotics (cefoxitin) in patients undergoing colectomy with ileoanal anastomosis [30].

Gene context of Colectomy

  • Colonic FAP severity was quantitated as the number of polyps per colectomy specimen, standardised for colon size [31].
  • Now that the deleterious genes at 2p and 3p have been identified, we are offering candidates, in whom the MSH2 or MLH1 mutation has been verified, an option of prophylactic subtotal colectomy as opposed to annual life time colonoscopy [32].
  • Thus, we evaluated perioperative plasma concentrations of soluble VEGF (sVEGF) and soluble VEGFR1 (sVEGFR1) in patients undergoing elective colectomy [33].
  • METHODS: Specific androgen (AR), estrogen (ER) and progesterone (PgR) receptors were measured in the tissue samples of 35 patients (15 males, 20 females) undergoing colectomy or coloproctectomy for adenocarcinoma [34].
  • CONCLUSIONS: Colectomy causes acute release of cytokines and CRP in both the portal and systemic circulation [35].

Analytical, diagnostic and therapeutic context of Colectomy


  1. The interleukin 1 receptor antagonist gene allele 2 as a predictor of pouchitis following colectomy and IPAA in ulcerative colitis. Carter, M.J., Di Giovine, F.S., Cox, A., Goodfellow, P., Jones, S., Shorthouse, A.J., Duff, G.W., Lobo, A.J. Gastroenterology (2001) [Pubmed]
  2. Ileorectal anastomosis is appropriate for a subset of patients with familial adenomatous polyposis. Bülow, C., Vasen, H., Järvinen, H., Björk, J., Bisgaard, M.L., Bülow, S. Gastroenterology (2000) [Pubmed]
  3. Hepatic metabolism of cholesterol in Crohn's disease. Effect of partial resection of ileum. Akerlund, J.E., Reihnér, E., Angelin, B., Rudling, M., Ewerth, S., Björkhem, I., Einarsson, K. Gastroenterology (1991) [Pubmed]
  4. Ileal adenomas after colectomy in nine patients with adenomatous polyposis coli/Gardner's syndrome. Hamilton, S.R., Bussey, H.J., Mendelsohn, G., Diamond, M.P., Pavlides, G., Hutcheon, D., Harbison, M., Shermeta, D., Morson, B.C., Yardley, J.H. Gastroenterology (1979) [Pubmed]
  5. Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment. Spagnesi, M.T., Tonelli, F., Dolara, P., Caderni, G., Valanzano, R., Anastasi, A., Bianchini, F. Gastroenterology (1994) [Pubmed]
  6. Neostigmine for the treatment of acute colonic pseudo-obstruction. Ponec, R.J., Saunders, M.D., Kimmey, M.B. N. Engl. J. Med. (1999) [Pubmed]
  7. Cyclosporine in severe ulcerative colitis refractory to steroid therapy. Lichtiger, S., Present, D.H., Kornbluth, A., Gelernt, I., Bauer, J., Galler, G., Michelassi, F., Hanauer, S. N. Engl. J. Med. (1994) [Pubmed]
  8. Short-term quality-of-life outcomes following laparoscopic-assisted colectomy vs open colectomy for colon cancer: a randomized trial. Weeks, J.C., Nelson, H., Gelber, S., Sargent, D., Schroeder, G. JAMA (2002) [Pubmed]
  9. Increased N-myristoyltransferase activity observed in rat and human colonic tumors. Magnuson, B.A., Raju, R.V., Moyana, T.N., Sharma, R.K. J. Natl. Cancer Inst. (1995) [Pubmed]
  10. Activated-carbon-oriented laparoscopic colectomy. Kitamura, K., Yamane, T., Shimotsuma, M., Hagiwara, A., Yamaguchi, T., Takahashi, T. Lancet (1995) [Pubmed]
  11. Hepatotoxic effect of bile acids in inflammatory bowel disease. Dew, M.J., van Berge Henegouwen, G.P., Huybregts, A.W., Allan, R.N. Gastroenterology (1980) [Pubmed]
  12. Influence of injury and nutrition on muscle water electrolytes: effect of elective operation. Bergström, J., Fürst, P., Holmström, B.U., Vinnars, E., Askanasi, J., Elwyn, D.H., Michelsen, C.B., Kinney, J.M. Ann. Surg. (1981) [Pubmed]
  13. Effect of azodisal sodium and sulphasalazine on ileostomy output of fluid and PGE2 and PGF2 alpha in subjects with a permanent ileostomy. Sandberg-Gertzén, H., Järnerot, G., Bukhave, K., Lauritsen, K., Rask-Madsen, J. Gut (1986) [Pubmed]
  14. Response of refractory colitis to intravenous or oral tacrolimus (FK506). Fellermann, K., Tanko, Z., Herrlinger, K.R., Witthoeft, T., Homann, N., Bruening, A., Ludwig, D., Stange, E.F. Inflamm. Bowel Dis. (2002) [Pubmed]
  15. Short- and long-term outcome of patients treated with cyclosporin for severe acute ulcerative colitis. Stack, W.A., Long, R.G., Hawkey, C.J. Aliment. Pharmacol. Ther. (1998) [Pubmed]
  16. The 'ileal brake' after ileal pouch-anal anastomosis. Soper, N.J., Chapman, N.J., Kelly, K.A., Brown, M.L., Phillips, S.F., Go, V.L. Gastroenterology (1990) [Pubmed]
  17. Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Brentnall, T.A., Crispin, D.A., Rabinovitch, P.S., Haggitt, R.C., Rubin, C.E., Stevens, A.C., Burmer, G.C. Gastroenterology (1994) [Pubmed]
  18. Female fecundity before and after operation for familial adenomatous polyposis. Olsen, K.Ø., Juul, S., Bülow, S., Järvinen, H.J., Bakka, A., Björk, J., Oresland, T., Laurberg, S. The British journal of surgery. (2003) [Pubmed]
  19. Reduced urinary and serum total estriol levels in pregnancies after colectomy. Osathanondh, R., Fencl, M.D., Schiff, I., Himmel, M., Tulchinsky, D. Obstetrics and gynecology. (1979) [Pubmed]
  20. The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon. Roberts, P.J., Riley, G.P., Morgan, K., Miller, R., Hunter, J.O., Middleton, S.J. J. Clin. Pathol. (2001) [Pubmed]
  21. DNA adducts, detected by 32P-postlabelling, in DNA treated in vitro with bile from patients with familial adenomatous polyposis and from unaffected controls. Scates, D.K., Spigelman, A.D., Nugent, K.P., Phillips, R.K., Venitt, S. Carcinogenesis (1993) [Pubmed]
  22. Estimation of tumor stage and lymph node status in patients with colorectal adenocarcinoma using probabilistic neural networks and logistic regression. Singson, R.P., Alsabeh, R., Geller, S.A., Marchevsky, A. Mod. Pathol. (1999) [Pubmed]
  23. The effects of elevated intraabdominal pressure, hypercarbia, and positioning on the hemodynamic responses to laparoscopic colectomy in pigs. Horvath, K.D., Whelan, R.L., Lier, B., Viscomi, S., Barry, L., Buck, K., Bessler, M. Surgical endoscopy. (1998) [Pubmed]
  24. Severe steroid-unresponsive ulcerative colitis: outcomes of restorative proctocolectomy in patients undergoing cyclosporin treatment. Pinna-Pintor, M., Arese, P., Bona, R., Falletto, E., Schieroni, R., Villata, E., Massaioli, N., Selvaggi, P., Actis, G.C., Lagget, M., Marzano, A., Ottobrelli, A., Sostegni, R., Torrani-Cerenzia, M.R., Rizzetto, M. Dis. Colon Rectum (2000) [Pubmed]
  25. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels: a prospective study. M'Koma, A.E., Lindquist, K., Liljeqvist, L. Dis. Colon Rectum (1999) [Pubmed]
  26. Controlled trial of intravenous hyperalimentation and total bowel rest as an adjunct to the routine therapy of acute colitis. Dickinson, R.J., Ashton, M.G., Axon, A.T., Smith, R.C., Yeung, C.K., Hill, G.L. Gastroenterology (1980) [Pubmed]
  27. Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis. Williamson, R.C., Bauer, F.L., Terpstra, O.T., Ross, J.S., Malt, R.A. Cancer Res. (1980) [Pubmed]
  28. Rapid cholesterol nucleation time and cholesterol gall stone formation after subtotal or total colectomy in humans. Makino, I., Chijiiwa, K., Higashijima, H., Nakahara, S., Kishinaka, M., Kuroki, S., Mibu, R. Gut (1994) [Pubmed]
  29. Controlled trial of intravenous metronidazole as an adjunct to corticosteroids in severe ulcerative colitis. Chapman, R.W., Selby, W.S., Jewell, D.P. Gut (1986) [Pubmed]
  30. Colectomy, mucosal proctectomy, and ileal pouch-anal anastomosis. A prospective trial of optimal antibiotic management. Becker, J.M., Alexander, D.P. Ann. Surg. (1991) [Pubmed]
  31. Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. Crabtree, M.D., Fletcher, C., Churchman, M., Hodgson, S.V., Neale, K., Phillips, R.K., Tomlinson, I.P. Gut (2004) [Pubmed]
  32. 25 years of HNPCC. Lynch, H.T., Lynch, J.F. Anticancer Res. (1994) [Pubmed]
  33. Influence of open versus laparoscopically assisted colectomy on soluble vascular endothelial growth factor (sVEGF) and its soluble receptor 1 (sVEGFR1). Svendsen, M.N., Werther, K., Christensen, I.J., Basse, L., Nielsen, H.J. Inflamm. Res. (2005) [Pubmed]
  34. Sex steroid receptors, secondary bile acids and colorectal cancer. A possible mechanism of interaction. Berta, L., Fronticelli Baldelli, C., Fazzari, A., Radice, E., Bargoni, A., Frairia, R., Gaetini, A. Panminerva medica. (2003) [Pubmed]
  35. Levels of portal and systemic blood cytokines after colectomy in patients with carcinoma or Crohn's disease. Riché, F., Dosquet, C., Panis, Y., Valleur, P., Laisné, M.J., Briard, C., Wautier, J.L. J. Am. Coll. Surg. (1995) [Pubmed]
  36. Appendectomy protects against the development of ulcerative colitis but does not affect its course. Selby, W.S., Griffin, S., Abraham, N., Solomon, M.J. Am. J. Gastroenterol. (2002) [Pubmed]
  37. Oral methotrexate in ulcerative colitis. Cummings, J.R., Herrlinger, K.R., Travis, S.P., Gorard, D.A., McIntyre, A.S., Jewell, D.P. Aliment. Pharmacol. Ther. (2005) [Pubmed]
  38. A comparison of the quality of life in patients with severe ulcerative colitis after total colectomy versus medical treatment with intravenous cyclosporin. Cohen, R.D., Brodsky, A.L., Hanauer, S.B. Inflamm. Bowel Dis. (1999) [Pubmed]
  39. Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer. Gupta, N., Martin, P.M., Miyauchi, S., Ananth, S., Herdman, A.V., Martindale, R.G., Podolsky, R., Ganapathy, V. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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