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Gene Review

Poll  -  polymerase (DNA directed), lambda

Mus musculus

Synonyms: 1110003P06Rik, AV007317, DNA polymerase kappa, DNA polymerase lambda, Pol Lambda, ...
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Disease relevance of Poll


High impact information on Poll


Biological context of Poll


Anatomical context of Poll


Associations of Poll with chemical compounds

  • Pol lambda also conserves the critical residues of Pol beta required for its intrinsic deoxyribose phosphate lyase (dRPase) activity [7].
  • We found here that another phenolic compound, curcumin (diferuloylmethane), which is known as an anti-chronic inflammatory agent and is structurally quite similar to petasiphenol, was also a potent pol lambda inhibitor [9].


  1. Disorder of the inhibitory glycine receptor: inherited myoclonus in Poll Hereford calves. Gundlach, A.L. FASEB J. (1990) [Pubmed]
  2. Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Kobayashi, Y., Watanabe, M., Okada, Y., Sawa, H., Takai, H., Nakanishi, M., Kawase, Y., Suzuki, H., Nagashima, K., Ikeda, K., Motoyama, N. Mol. Cell. Biol. (2002) [Pubmed]
  3. The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair. Ogi, T., Lehmann, A.R. Nat. Cell Biol. (2006) [Pubmed]
  4. The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Trivedi, R.N., Almeida, K.H., Fornsaglio, J.L., Schamus, S., Sobol, R.W. Cancer Res. (2005) [Pubmed]
  5. Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia. Zariwala, M., O'Neal, W.K., Noone, P.G., Leigh, M.W., Knowles, M.R., Ostrowski, L.E. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  6. DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. Braithwaite, E.K., Prasad, R., Shock, D.D., Hou, E.W., Beard, W.A., Wilson, S.H. J. Biol. Chem. (2005) [Pubmed]
  7. DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. García-Díaz, M., Domínguez, O., López-Fernández, L.A., de Lera, L.T., Saníger, M.L., Ruiz, J.F., Párraga, M., García-Ortiz, M.J., Kirchhoff, T., del Mazo, J., Bernad, A., Blanco, L. J. Mol. Biol. (2000) [Pubmed]
  8. Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa. Velasco-Miguel, S., Richardson, J.A., Gerlach, V.L., Lai, W.C., Gao, T., Russell, L.D., Hladik, C.L., White, C.L., Friedberg, E.C. DNA Repair (Amst.) (2003) [Pubmed]
  9. Some anti-chronic inflammatory compounds are DNA polymerase lambda-specific inhibitors. Mizushina, Y., Hirota, M., Murakami, C., Ishidoh, T., Kamisuki, S., Shimazaki, N., Takemura, M., Perpelescu, M., Suzuki, M., Yoshida, H., Sugawara, F., Koiwai, O., Sakaguchi, K. Biochem. Pharmacol. (2003) [Pubmed]
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