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MeSH Review


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Disease relevance of Sinusitis


Psychiatry related information on Sinusitis


High impact information on Sinusitis

  • Secondary complications such as bronchitis and sinusitis occurred in 15% of placebo recipients compared with 7% of combined oseltamivir recipients (P = .03) [8].
  • The published literature weakly supports a positive association between GER and both sinusitis and laryngeal malignancy, and a negative association between GER and otitis media [4].
  • This study was conducted to review and evaluate the published evidence for an association between gastroesophageal reflux (GER) and 3 supraesophageal pathologies: sinusitis, otitis media, and laryngeal malignancy [4].
  • SETTING: The Johns Hopkins Hospital. RESULTS: Sinusitis was identified in 72 HIV-infected patients, predominantly individuals with a CD4 cell count of less than 200/mm3 [9].
  • In this study, a 5-day course (one dose per day) of azithromycin proved to have efficacy, safety, and tolerability that was equal to a 10-day course (three doses per day) of amoxicillin in the treatment of acute bacterial sinusitis [10].

Chemical compound and disease context of Sinusitis

  • A case of sinusitis due to Aspergillus flavus that developed in a patient with acute leukemia during the third week of treatment with amphotericin B is described [11].
  • Amoxicillin is appropriate therapy for patients with uncomplicated sinusitis in geographic areas in which the prevalence of beta-lactamase-producing pathogens is less than 20% [12].
  • Erythromycin (EM) and its 14-member macrolide analogues have attracted attention for its effectiveness in a variety of airway diseases, including diffuse panbronchiolitis (DPB), sinobronchial syndrome, and chronic sinusitis [13].
  • The mean +/- SEM NO nasal concentration in children with sinusitis was 70 +/- 8.7 parts per billion (ppb) and increased significantly to 220 +/- 15 ppb (p < 0.001) after antibiotic therapy (amoxicillin/clavulanate) [14].
  • BACKGROUND: The need for antimicrobials in the treatment of subacute sinusitis was evaluated in 96 afebrile children who were prescribed antimicrobial (amoxicillin, amoxicillin clavulanate potassium, or trimethoprim-sulfamethoxazole) or no antimicrobial medication in addition to a decongestant and saline nasal spray for 3 weeks [15].

Biological context of Sinusitis


Anatomical context of Sinusitis


Gene context of Sinusitis

  • Immunoreactive interleukin-1 (IL-1) alpha and beta levels in nasal polyp (NP) extracts were measured from 22 adult patients with chronic sinusitis (CS) in order to determine their significance in the pathogenesis of NP [25].
  • From this preliminary study, we conclude that nasal mucus is not a suitable substitute for sinus mucus in sinus mucin gene studies and that different pathological processes are taking place in nasal and sinus tissue in chronic sinusitis [26].
  • Mutations of the CFTR gene can lead either to cystic fibrosis or to idiopathic chronic pancreatitis, and to a variety of cystic fibrosis-associated disorders, including congenital bilateral absence of the vas deferens and sinusitis [27].
  • Interleukin-1 beta (IL-1 beta) is a predominant cytokine in retained paranasal sinus fluid of chronic sinusitis where infiltration by polymorphonuclear neutrophils (PMNs) of nasal and paranasal mucosa is characteristic [28].
  • Interleukin-1 beta, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in chronic sinusitis: response to systemic corticosteroids [29].

Analytical, diagnostic and therapeutic context of Sinusitis


  1. Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial. Dolor, R.J., Witsell, D.L., Hellkamp, A.S., Williams, J.W., Califf, R.M., Simel, D.L. JAMA (2001) [Pubmed]
  2. Bilateral optic neuropathy and osteolytic sinusitis. Complications of cocaine abuse. Newman, N.M., DiLoreto, D.A., Ho, J.T., Klein, J.C., Birnbaum, N.S. JAMA (1988) [Pubmed]
  3. Botulism associated with Clostridium botulinum sinusitis after intranasal cocaine abuse. Kudrow, D.B., Henry, D.A., Haake, D.A., Marshall, G., Mathisen, G.E. Ann. Intern. Med. (1988) [Pubmed]
  4. Association between gastroesophageal reflux and sinusitis, otitis media, and laryngeal malignancy: a systematic review of the evidence. Weaver, E.M. Am. J. Med. (2003) [Pubmed]
  5. Bacterial bronchitis and bronchiectasis in human immunodeficiency virus infection. Verghese, A., al-Samman, M., Nabhan, D., Naylor, A.D., Rivera, M. Arch. Intern. Med. (1994) [Pubmed]
  6. Effect of oxymetazoline nose drops on acute sinusitis in the rabbit. Bende, M., Fukami, M., Arfors, K.E., Mark, J., Stierna, P., Intaglietta, M. The Annals of otology, rhinology, and laryngology. (1996) [Pubmed]
  7. A retrospective study of risk factors for repeated admissions for asthma in a rural/suburban university hospital. Kuo, A., Craig, T.J. The Journal of the American Osteopathic Association. (2001) [Pubmed]
  8. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group. Treanor, J.J., Hayden, F.G., Vrooman, P.S., Barbarash, R., Bettis, R., Riff, D., Singh, S., Kinnersley, N., Ward, P., Mills, R.G. JAMA (2000) [Pubmed]
  9. Sinusitis in HIV-infected patients: a clinical and radiographic review. Godofsky, E.W., Zinreich, J., Armstrong, M., Leslie, J.M., Weikel, C.S. Am. J. Med. (1992) [Pubmed]
  10. Azithromycin and amoxicillin in the treatment of acute maxillary sinusitis. Casiano, R.R. Am. J. Med. (1991) [Pubmed]
  11. Development of Aspergillus sinusitis in a patient receiving amphotericin B. Treatment with granulocyte transfusions. Swerdlow, B., Deresinski, S. Am. J. Med. (1984) [Pubmed]
  12. Antimicrobial therapy of pediatric patients with sinusitis. Wald, E.R. J. Allergy Clin. Immunol. (1992) [Pubmed]
  13. Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. Takizawa, H., Desaki, M., Ohtoshi, T., Kawasaki, S., Kohyama, T., Sato, M., Tanaka, M., Kasama, T., Kobayashi, K., Nakajima, J., Ito, K. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  14. Effect of antibiotic therapy on nasal nitric oxide concentration in children with acute sinusitis. Baraldi, E., Azzolin, N.M., Biban, P., Zacchello, F. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  15. Subacute sinusitis: are antimicrobials necessary? Dohlman, A.W., Hemstreet, M.P., Odrezin, G.T., Bartolucci, A.A. J. Allergy Clin. Immunol. (1993) [Pubmed]
  16. Multiple sclerosis associated with sinusitis: case-controlled study in general practice. Gay, D., Dick, G., Upton, G. Lancet (1986) [Pubmed]
  17. Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha. Hamilos, D.L., Leung, D.Y., Wood, R., Bean, D.K., Song, Y.L., Schotman, E., Hamid, Q. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  18. Maxillary sinusitis as a surrogate model for CF gene therapy clinical trials in patients with antrostomies. Wagner, J.A., Nepomuceno, I.B., Shah, N., Messner, A.H., Moran, M.L., Norbash, A.M., Moss, R.B., Wine, J.J., Gardner, P. The journal of gene medicine. (1999) [Pubmed]
  19. Adverse effect of air pollution on respiratory health of primary school children in Taiwan. Chen, P.C., Lai, Y.M., Wang, J.D., Yang, C.Y., Hwang, J.S., Kuo, H.W., Huang, S.L., Chan, C.C. Environ. Health Perspect. (1998) [Pubmed]
  20. Science and medicine of canoeing and kayaking. Shephard, R.J. Sports medicine (Auckland, N.Z.) (1987) [Pubmed]
  21. Sinusitis in adults and its relation to allergic rhinitis, asthma, and nasal polyps. Slavin, R.G. J. Allergy Clin. Immunol. (1988) [Pubmed]
  22. Allergic fungal sinusitis: an immunohistologic analysis. Khan, D.A., Cody, D.T., George, T.J., Gleich, G.J., Leiferman, K.M. J. Allergy Clin. Immunol. (2000) [Pubmed]
  23. Mechanism of neutrophil recruitment induced by IL-8 in chronic sinusitis. Suzuki, H., Takahashi, Y., Wataya, H., Ikeda, K., Nakabayashi, S., Shimomura, A., Takasaka, T. J. Allergy Clin. Immunol. (1996) [Pubmed]
  24. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Minshall, E.M., Cameron, L., Lavigne, F., Leung, D.Y., Hamilos, D., Garcia-Zepada, E.A., Rothenberg, M., Luster, A.D., Hamid, Q. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  25. Quantitation and immunocytological identification of interleukin-1 in nasal polyps from patients with chronic sinusitis. Hamaguchi, Y., Suzumura, H., Arima, S., Sakakura, Y. Int. Arch. Allergy Immunol. (1994) [Pubmed]
  26. Mixed nasal mucus as a model for sinus mucin gene expression studies. Ali, M.S., Wilson, J.A., Pearson, J.P. Laryngoscope (2002) [Pubmed]
  27. Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments for the motion. Whitcomb, D.C. Can. J. Gastroenterol. (2003) [Pubmed]
  28. Localization of IL-1 beta mRNA and cell adhesion molecules in the maxillary sinus mucosa of patients with chronic sinusitis. Tokushige, E., Itoh, K., Ushikai, M., Katahira, S., Fukuda, K. Laryngoscope (1994) [Pubmed]
  29. Interleukin-1 beta, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in chronic sinusitis: response to systemic corticosteroids. Lennard, C.M., Mann, E.A., Sun, L.L., Chang, A.S., Bolger, W.E. American journal of rhinology. (2000) [Pubmed]
  30. Randomized double-blind study comparing 3- and 6-day regimens of azithromycin with a 10-day amoxicillin-clavulanate regimen for treatment of acute bacterial sinusitis. Henry, D.C., Riffer, E., Sokol, W.N., Chaudry, N.I., Swanson, R.N. Antimicrob. Agents Chemother. (2003) [Pubmed]
  31. Myeloperoxidase and interleukin-8 levels in chronic sinusitis. Demoly, P., Crampette, L., Mondain, M., Enander, I., Jones, I., Bousquet, J. Clin. Exp. Allergy (1997) [Pubmed]
  32. Cure of Rhizopus sinusitis in a liver transplant recipient with liposomal amphotericin B. Munckhof, W., Jones, R., Tosolini, F.A., Marzec, A., Angus, P., Grayson, M.L. Clin. Infect. Dis. (1993) [Pubmed]
  33. Treatment of upper and lower respiratory tract infections: clinical trials with cefprozil. Aronovitz, G. Pediatr. Infect. Dis. J. (1998) [Pubmed]
  34. Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin. Kraft, M., Cassell, G.H., Pak, J., Martin, R.J. Chest (2002) [Pubmed]
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