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Gene Review

REXO1  -  REX1, RNA exonuclease 1 homolog (S....

Homo sapiens

Synonyms: ELOABP1, EloA-BP1, Elongin-A-binding protein 1, KIAA1138, REX1, ...
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Disease relevance of REXO1

  • By using fresh peripheral blood mononuclear cells, the expression of tax1/rex1 mRNA was detected in five of the six adult T-cell leukemia patients and four of the eight HTLV-I carriers examined [1].
  • Furthermore, a p21X protein lacking the N-terminus of Rex1 was expressed at high levels; our data indicate that p21X is translated from the 1.6-kb mRNA which is derived primarily from deleted proviruses [2].

High impact information on REXO1

  • The Leishmania major RNA ligase-containing complex protein 2 expressed in insect cells has a 3'-5' exoribonuclease activity and was therefore renamed RNA editing exonuclease 1 (REX1) [3].
  • The evidence involves both in vivo down-regulation of REX1 expression in Trypanosoma brucei by RNA interference and the reconstitution of precleaved U-deletion in vitro editing with only two recombinant enzymes: recombinant REX1 and recombinant RNA editing ligase 1 [3].
  • The amounts of tax1/rex1 mRNA detected corresponded to approximately 10(5) to 10(6) times less than that in the HTLV-I-infected MT-2 cell line [1].
  • REX1, a novel gene required for DNA repair [4].
  • At least three of these ancient Rex1 lineages were detected within the genome of poeciliids [5].

Biological context of REXO1


Anatomical context of REXO1


Associations of REXO1 with chemical compounds

  • We discovered that, at proliferative state, these cells express transcription factors of pluripotent cells, OCT-3/4 and REX-1, and embryonic cell surface antigens SSEA-1, SSEA-3, and SSEA-4, as well as TRA-1-60 and TRA-1-81 [7].

Other interactions of REXO1


Analytical, diagnostic and therapeutic context of REXO1

  • The presence of a premature termination codon in the Tax1/Rex1 mRNA encoded by the full-length provirus was inferred from the presence of small Rex1-related polypeptides lacking C-terminal sequences and confirmed by sequence analysis [2].


  1. Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Kinoshita, T., Shimoyama, M., Tobinai, K., Ito, M., Ito, S., Ikeda, S., Tajima, K., Shimotohno, K., Sugimura, T. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. HTLV-1 gene expression by defective proviruses in an infected T-cell line. Bhat, N.K., Adachi, Y., Samuel, K.P., Derse, D. Virology (1993) [Pubmed]
  3. Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes. Kang, X., Rogers, K., Gao, G., Falick, A.M., Zhou, S., Simpson, L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. REX1, a novel gene required for DNA repair. Cenkci, B., Petersen, J.L., Small, G.D. J. Biol. Chem. (2003) [Pubmed]
  5. Multiple lineages of the non-LTR retrotransposon Rex1 with varying success in invading fish genomes. Volff, J.N., Körting, C., Schartl, M. Mol. Biol. Evol. (2000) [Pubmed]
  6. The putative human stem cell marker, Rex-1 (Zfp42): Structural classification and expression in normal human epithelial and carcinoma cell cultures. Mongan, N.P., Martin, K.M., Gudas, L.J. Mol. Carcinog. (2006) [Pubmed]
  7. Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Rieske, P., Krynska, B., Azizi, S.A. Differentiation (2005) [Pubmed]
  8. Taking U out, with two nucleases? Mian, I.S., Worthey, E.A., Salavati, R. BMC Bioinformatics (2006) [Pubmed]
  9. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. Tamura, K., Miyata, K., Sugahara, K., Onishi, S., Shuin, T., Aso, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells. D'Ippolito, G., Diabira, S., Howard, G.A., Roos, B.A., Schiller, P.C. Bone (2006) [Pubmed]
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