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Gene Review

PTBP2  -  polypyrimidine tract binding protein 2

Homo sapiens

Synonyms: NPTB, Neural polypyrimidine tract-binding protein, Neurally-enriched homolog of PTB, PTB, PTB-like protein, ...
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Disease relevance of PTBP2


High impact information on PTBP2


Chemical compound and disease context of PTBP2

  • To investigate the mechanism of hyperinsulinaemia in rats with acute liver failure induced by the administration of d-galactosamine (GalN), we focused on the role of polyprimidine tract-binding protein (PTB) in islet insulin synthesis [9].

Biological context of PTBP2


Anatomical context of PTBP2


Associations of PTBP2 with chemical compounds


Analytical, diagnostic and therapeutic context of PTBP2

  • By means of genomic sequence analysis we have isolated and cloned a 1587-base pair region upstream the human nPTB coding region [1].
  • Using UV cross-linking and immunoprecipitation experiments with site-specific labeled RNA in PTB-depleted nuclear extracts, we found that the decrease in PTB was correlated with an increase in U2AF65 [11].
  • PTB in the DRM was resistant to protease digestion, but became sensitive after treatment with the raft-disrupting agents [18].
  • By bromouridine triphosphate (BrUTP) labeling and confocal microscopy of cells harboring an HCV replicon, we showed that the newly synthesized HCV RNA was localized to distinct structures in the cytoplasm, which also contain PTB [18].
  • Overexpression of PTB in resting CD4+ T cells from patients on HAART allowed cytoplasmic accumulation of HIV-1 RNAs [19].


  1. Identification and analysis of the human neural polypyrimidine tract binding protein (nPTB) gene promoter region. Romanelli, M.G., Lorenzi, P., Morandi, C. Gene (2005) [Pubmed]
  2. Molecular cloning and characterization of a new neuron-specific homologue of rat polypyrimidine tract binding protein. Kikuchi, T., Ichikawa, M., Arai, J., Tateiwa, H., Fu, L., Higuchi, K., Yoshimura, N. J. Biochem. (2000) [Pubmed]
  3. Functional significance of the interaction of hepatitis A virus RNA with glyceraldehyde 3-phosphate dehydrogenase (GAPDH): opposing effects of GAPDH and polypyrimidine tract binding protein on internal ribosome entry site function. Yi, M., Schultz, D.E., Lemon, S.M. J. Virol. (2000) [Pubmed]
  4. A novel isoform ratio switch of the polypyrimidine tract binding protein. Wagner, E.J., Carstens, R.P., Garcia-Blanco, M.A. Electrophoresis (1999) [Pubmed]
  5. The polypyrimidine tract-binding protein (PTB) is required for efficient replication of hepatitis C virus (HCV) RNA. Chang, K.S., Luo, G. Virus Res. (2006) [Pubmed]
  6. MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Boutz, P.L., Chawla, G., Stoilov, P., Black, D.L. Genes Dev. (2007) [Pubmed]
  7. Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry. Mitchell, S.A., Spriggs, K.A., Bushell, M., Evans, J.R., Stoneley, M., Le Quesne, J.P., Spriggs, R.V., Willis, A.E. Genes Dev. (2005) [Pubmed]
  8. The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. Moreira, A., Takagaki, Y., Brackenridge, S., Wollerton, M., Manley, J.L., Proudfoot, N.J. Genes Dev. (1998) [Pubmed]
  9. Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure. Kuwahata, M., Tomoe, Y., Harada, N., Amano, S., Segawa, H., Tatsumi, S., Ito, M., Oka, T., Miyamoto, K. Biochim. Biophys. Acta (2007) [Pubmed]
  10. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mitchell, S.A., Spriggs, K.A., Coldwell, M.J., Jackson, R.J., Willis, A.E. Mol. Cell (2003) [Pubmed]
  11. The Polypyrimidine Tract Binding Protein (PTB) Represses Splicing of Exon 6B from the {beta}-Tropomyosin Pre-mRNA by Directly Interfering with the Binding of the U2AF65 Subunit. Sauli??re, J., Sureau, A., Expert-Bezan??on, A., Marie, J. Mol. Cell. Biol. (2006) [Pubmed]
  12. Polypyrimidine tract-binding protein down-regulates fibroblast growth factor receptor 1 alpha-exon inclusion. Jin, W., Bruno, I.G., Xie, T.X., Sanger, L.J., Cote, G.J. Cancer Res. (2003) [Pubmed]
  13. Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. Gromak, N., Matlin, A.J., Cooper, T.A., Smith, C.W. RNA (2003) [Pubmed]
  14. The Polypyrimidine Tract-binding Protein (PTB) Is Involved in the Post-transcriptional Regulation of Human Inducible Nitric Oxide Synthase Expression. Pautz, A., Linker, K., Hubrich, T., Korhonen, R., Altenh??fer, S., Kleinert, H. J. Biol. Chem. (2006) [Pubmed]
  15. Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA. De Nova-Ocampo, M., Villegas-Sepúlveda, N., del Angel, R.M. Virology (2002) [Pubmed]
  16. A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain. Rideau, A.P., Gooding, C., Simpson, P.J., Monie, T.P., Lorenz, M., Hüttelmaier, S., Singer, R.H., Matthews, S., Curry, S., Smith, C.W. Nat. Struct. Mol. Biol. (2006) [Pubmed]
  17. Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane. Stroeken, P.J., Alvarez, B., Van Rheenen, J., Wijnands, Y.M., Geerts, D., Jalink, K., Roos, E. J. Cell. Physiol. (2006) [Pubmed]
  18. Polypyrimidine-tract-binding protein is a component of the HCV RNA replication complex and necessary for RNA synthesis. Aizaki, H., Choi, K.S., Liu, M., Li, Y.J., Lai, M.M. J. Biomed. Sci. (2006) [Pubmed]
  19. Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells. Lassen, K.G., Ramyar, K.X., Bailey, J.R., Zhou, Y., Siliciano, R.F. PLoS Pathog. (2006) [Pubmed]
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