Gene Review:
ABCB4 - ATP-binding cassette, sub-family B...
Homo sapiens
Synonyms:
ABC21, ATP-binding cassette sub-family B member 4, GBD1, ICP3, MDR2, ...
Sugiyama,
Kosters,
Portincasa,
Cohen,
Ban,
Meier,
Groen,
Kullak-Ublick,
vanBerge-Henegouwen,
Venneman,
Tsuji,
Mizutani,
Ikegami,
Terabe,
Sugiura,
Togari,
Tanaka,
Weiss,
Schiff,
Parada,
Pauli-Magnus,
Schwartz,
Kusama,
Kerb,
Inada,
Anwald,
Sugiyama,
Keelan,
Lang,
Suzuki,
van Erpecum,
Beuers,
Shoda,
Fattinger,
Evseenko,
Paxton,
Ueda,
Ando,
Goto,
- Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. Schneider, G., Paus, T.C., Kullak-Ublick, G.A., Meier, P.J., Wienker, T.F., Lang, T., van de Vondel, P., Sauerbruch, T., Reichel, C. Hepatology (2007)
- Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4. Shoda, J., Inada, Y., Tsuji, A., Kusama, H., Ueda, T., Ikegami, T., Suzuki, H., Sugiyama, Y., Cohen, D.E., Tanaka, N. J. Lipid Res. (2004)
- Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian cancer cells. Duan, Z., Brakora, K.A., Seiden, M.V. Mol. Cancer Ther. (2004)
- Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. Herweijer, H., Sonneveld, P., Baas, F., Nooter, K. J. Natl. Cancer Inst. (1990)
- Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter ABCB4 gene. Wasmuth, H.E., Glantz, A., Keppeler, H., Simon, E., Bartz, C., Rath, W., Mattsson, L.A., Marschall, H.U., Lammert, F. Gut (2007)
- MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. van Helvoort, A., Smith, A.J., Sprong, H., Fritzsche, I., Schinkel, A.H., Borst, P., van Meer, G. Cell (1996)
- P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. Schinkel, A.H., Wagenaar, E., Mol, C.A., van Deemter, L. J. Clin. Invest. (1996)
- Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. Schinkel, A.H., Wagenaar, E., van Deemter, L., Mol, C.A., Borst, P. J. Clin. Invest. (1995)
- Activity of P-glycoprotein in B-cell chronic lymphocytic leukemia determined by a flow cytometric assay. Ludescher, C., Hilbe, W., Eisterer, W., Preuss, E., Huber, C., Gotwald, M., Hofmann, J., Thaler, J. J. Natl. Cancer Inst. (1993)
- ABCB4 gene mutation-associated cholelithiasis in adults. Rosmorduc, O., Hermelin, B., Boelle, P.Y., Parc, R., Taboury, J., Poupon, R. Gastroenterology (2003)
- MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. Rosmorduc, O., Hermelin, B., Poupon, R. Gastroenterology (2001)
- Analysis of the in vivo functions of Mrp3. Belinsky, M.G., Dawson, P.A., Shchaveleva, I., Bain, L.J., Wang, R., Ling, V., Chen, Z.S., Grinberg, A., Westphal, H., Klein-Szanto, A., Lerro, A., Kruh, G.D. Mol. Pharmacol. (2005)
- Spontaneous multidrug transport in human glioma cells is regulated by transforming growth factors type beta. Schluesener, H.J., Meyermann, R. Acta Neuropathol. (1991)
- Effects of type and level of training on variation in physician knowledge in the use and acquisition of blood cultures: a cross sectional survey. Parada, J.P., Schwartz, D.N., Schiff, G.D., Weiss, K.B. BMC Infect. Dis. (2005)
- Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11). Lang, T., Haberl, M., Jung, D., Drescher, A., Schlagenhaufer, R., Keil, A., Mornhinweg, E., Stieger, B., Kullak-Ublick, G.A., Kerb, R. Drug Metab. Dispos. (2006)
- The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. Van der Bliek, A.M., Baas, F., Ten Houte de Lange, T., Kooiman, P.M., Van der Velde-Koerts, T., Borst, P. EMBO J. (1987)
- Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells. Zhao, J.Y., Ikeguchi, M., Eckersberg, T., Kuo, M.T. Endocrinology (1993)
- ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Evseenko, D.A., Paxton, J.W., Keelan, J.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006)
- Relevance of hereditary defects in lipid transport proteins for the pathogenesis of cholesterol gallstone disease. vanBerge-Henegouwen, G.P., Venneman, N.G., Portincasa, P., Kosters, A., van Erpecum, K.J., Groen, A.K. Scand. J. Gastroenterol. Suppl. (2004)
- Farnesoid X receptor activates transcription of the phospholipid pump MDR3. Huang, L., Zhao, A., Lew, J.L., Zhang, T., Hrywna, Y., Thompson, J.R., de Pedro, N., Royo, I., Blevins, R.A., Peláez, F., Wright, S.D., Cui, J. J. Biol. Chem. (2003)
- Expression of the MDR1 and MDR3 gene products in acute and chronic leukemias. Arai, Y., Masuda, M., Sugawara, I., Arai, T., Motoji, T., Tsuruo, T., Oshimi, K., Mizoguchi, H. Leuk. Res. (1997)
- MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. Smith, A.J., van Helvoort, A., van Meer, G., Szabo, K., Welker, E., Szakacs, G., Varadi, A., Sarkadi, B., Borst, P. J. Biol. Chem. (2000)
- Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies. Schinkel, A.H., Roelofs, E.M., Borst, P. Cancer Res. (1991)
- Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Keitel, V., Burdelski, M., Warskulat, U., Kühlkamp, T., Keppler, D., Häussinger, D., Kubitz, R. Hepatology (2005)
- Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. Stöckel, B., König, J., Nies, A.T., Cui, Y., Brom, M., Keppler, D. Eur. J. Biochem. (2000)
- Frequent expression of P-glycoprotein/MDR1 by nasal T-cell lymphoma cells. Yamaguchi, M., Kita, K., Miwa, H., Nishii, K., Oka, K., Ohno, T., Shirakawa, S., Fukumoto, M. Cancer (1995)
- Bile salt export pump gene mutations in two Japanese patients with progressive familial intrahepatic cholestasis. Goto, K., Sugiyama, K., Sugiura, T., Ando, T., Mizutani, F., Terabe, K., Ban, K., Togari, H. J. Pediatr. Gastroenterol. Nutr. (2003)
- Hepatic expression of ABC transporters G5 and G8 does not correlate with biliary cholesterol secretion in liver transplant patients. Geuken, E., Visser, D.S., Leuvenink, H.G., de Jong, K.P., Peeters, P.M., Slooff, M.J., Kuipers, F., Porte, R.J. Hepatology (2005)
- BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. Pauli-Magnus, C., Kerb, R., Fattinger, K., Lang, T., Anwald, B., Kullak-Ublick, G.A., Beuers, U., Meier, P.J. Hepatology (2004)
- MDR-1, but not MDR-3 gene expression, is associated with unmutated IgVH genes and poor prognosis chromosomal aberrations in chronic lymphocytic leukemia. Matthews, C., Catherwood, M.A., Larkin, A.M., Clynes, M., Morris, T., Alexander, H.D. Leuk. Lymphoma (2006)
- Differential regulation of mdr genes in response to 2-acetylaminofluorene treatment in cultured rat and human hepatocytes. Lecureur, V., Guillouzo, A., Fardel, O. Carcinogenesis (1996)