Gene Review:
RFX5 - regulatory factor X, 5 (influences HLA...
Homo sapiens
Synonyms:
DNA-binding protein RFX5, Regulatory factor X 5
- Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Gajiwala, K.S., Chen, H., Cornille, F., Roques, B.P., Reith, W., Mach, B., Burley, S.K. Nature (2000)
- Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency. Villard, J., Reith, W., Barras, E., Gos, A., Morris, M.A., Antonarakis, S.E., Van den Elsen, P.J., Mach, B. Hum. Mutat. (1997)
- Cleavage-dependent activation of a chlamydia-secreted protease. Dong, F., Pirbhai, M., Zhong, Y., Zhong, G. Mol. Microbiol. (2004)
- Assembly of functional regulatory complexes on MHC class II promoters in vivo. Fontes, J.D., Jabrane-Ferrat, N., Peterlin, B.M. J. Mol. Biol. (1997)
- Regulation of MHC class II genes: lessons from a disease. Mach, B., Steimle, V., Martinez-Soria, E., Reith, W. Annu. Rev. Immunol. (1996)
- A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Steimle, V., Durand, B., Barras, E., Zufferey, M., Hadam, M.R., Mach, B., Reith, W. Genes Dev. (1995)
- Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Clausen, B.E., Waldburger, J.M., Schwenk, F., Barras, E., Mach, B., Rajewsky, K., Förster, I., Reith, W. Immunity (1998)
- A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y. Villard, J., Peretti, M., Masternak, K., Barras, E., Caretti, G., Mantovani, R., Reith, W. Mol. Cell. Biol. (2000)
- Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex. Xu, Y., Wang, L., Buttice, G., Sengupta, P.K., Smith, B.D. J. Biol. Chem. (2003)
- The RFX family interacts at the collagen (COL1A2) start site and represses transcription. Sengupta, P.K., Fargo, J., Smith, B.D. J. Biol. Chem. (2002)
- A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression. Nagarajan, U.M., Long, A.B., Harreman, M.T., Corbett, A.H., Boss, J.M. J. Immunol. (2004)
- Analysis of the defect in IFN-gamma induction of MHC class II genes in G1B cells: identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X 5 transcription factor. Brickey, W.J., Wright, K.L., Zhu, X.S., Ting, J.P. J. Immunol. (1999)
- Transcriptional control of MHC genes in fetal trophoblast cells. van den Elsen, P.J., Gobin, S.J., van der Stoep, N., Datema, G., Viëtor, H.E. J. Reprod. Immunol. (2001)
- Associations and interactions between bare lymphocyte syndrome factors. DeSandro, A.M., Nagarajan, U.M., Boss, J.M. Mol. Cell. Biol. (2000)
- Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells. Butticè, G., Miller, J., Wang, L., Smith, B.D. Circ. Res. (2006)
- Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells. Zhong, G., Liu, L., Fan, T., Fan, P., Ji, H. J. Exp. Med. (2000)
- Collagen alpha1(I) gene (COL1A1) is repressed by RFX family. Sengupta, P., Xu, Y., Wang, L., Widom, R., Smith, B.D. J. Biol. Chem. (2005)
- Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. Scholl, T., Mahanta, S.K., Strominger, J.L. Proc. Natl. Acad. Sci. U.S.A. (1997)
- A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. Masternak, K., Barras, E., Zufferey, M., Conrad, B., Corthals, G., Aebersold, R., Sanchez, J.C., Hochstrasser, D.F., Mach, B., Reith, W. Nat. Genet. (1998)
- Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma). Xu, Y., Wang, L., Butticè, G., Sengupta, P.K., Smith, B.D. J. Biol. Chem. (2004)
- Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression. Xu, Y., Sengupta, P.K., Seto, E., Smith, B.D. J. Biol. Chem. (2006)
- Expression and translocation of chlamydial protease during acute and persistent infection of the epithelial HEp-2 cells with Chlamydophila (Chlamydia) pneumoniae. Heuer, D., Brinkmann, V., Meyer, T.F., Szczepek, A.J. Cell. Microbiol. (2003)
- Assembly of major histocompatability complex (MHC) class II transcription factors: association and promoter recognition of RFX proteins. Burd, A.L., Ingraham, R.H., Goldrick, S.E., Kroe, R.R., Crute, J.J., Grygon, C.A. Biochemistry (2004)