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Gene Review

CENPH  -  centromere protein H

Homo sapiens

Synonyms: CENP-H, Centromere protein H, ICEN35, Interphase centromere complex protein 35
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Disease relevance of CENPH


High impact information on CENPH

  • We have analyzed a functional human centromere and defined a region of increased chromosome scaffold/matrix attachment that overlaps three other distinct and nonoverlapping domains for constitutive centromere proteins CENP-A and CENP-H, and heterochromatin protein HP1 [3].
  • Here, we isolated a multi-subunit complex, which includes the established inner kinetochore components CENP-H and CENP-I, and nine other proteins, from both human and chicken cells [4].
  • The checkpoint protein BubR1, the fibrous corona component centromere protein (CENP) E, and the inner kinetochore proteins CENP-A and CENP-H also failed to accumulate to wild-type levels in depleted cells [5].
  • Coimmunoprecipitation experiments revealed that CENP-50 interacted with the CENP-H/CENP-I complex in chicken DT40 cells [6].
  • Moreover, CENP-H stable transfectant of mouse embryonic fibroblast/3T3 cell lines showed aberrant interphase micronuclei, characteristic of chromosome missegregation [1].

Biological context of CENPH


Anatomical context of CENPH


Other interactions of CENPH

  • Strong reduction of CENP-H resulted in a slightly reduced CENP-C level at the kinetochores and normal localisation of hBubR1, indicating a functional mitotic checkpoint at the hBubR1 protein level [9].
  • In CENP-H knocked-down human cells, the misaligned chromosomes contained only reduced levels of CENP-E [9].
  • Centromeric localization of CENP-50 was abolished in both CENP-H- and CENP-I-deficient cells [6].
  • A significant correlation between the expression levels of CENP-H protein and the Ki-67 labeling index was found (Mann-Whitney U test, P=0.005) [2].

Analytical, diagnostic and therapeutic context of CENPH


  1. Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Tomonaga, T., Matsushita, K., Ishibashi, M., Nezu, M., Shimada, H., Ochiai, T., Yoda, K., Nomura, F. Cancer Res. (2005) [Pubmed]
  2. Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S., Taki, M., Kamata, N. Oncol. Rep. (2006) [Pubmed]
  3. Transcription within a functional human centromere. Saffery, R., Sumer, H., Hassan, S., Wong, L.H., Craig, J.M., Todokoro, K., Anderson, M., Stafford, A., Choo, K.H. Mol. Cell (2003) [Pubmed]
  4. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Okada, M., Cheeseman, I.M., Hori, T., Okawa, K., McLeod, I.X., Yates, J.R., Desai, A., Fukagawa, T. Nat. Cell Biol. (2006) [Pubmed]
  5. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. Kline, S.L., Cheeseman, I.M., Hori, T., Fukagawa, T., Desai, A. J. Cell Biol. (2006) [Pubmed]
  6. The constitutive centromere component CENP-50 is required for recovery from spindle damage. Minoshima, Y., Hori, T., Okada, M., Kimura, H., Haraguchi, T., Hiraoka, Y., Bao, Y.C., Kawashima, T., Kitamura, T., Fukagawa, T. Mol. Cell. Biol. (2005) [Pubmed]
  7. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Niikura, Y., Ohta, S., Vandenbeldt, K.J., Abdulle, R., McEwen, B.F., Kitagawa, K. Oncogene (2006) [Pubmed]
  8. Centromere protein h is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Liao, W.T., Song, L.B., Zhang, H.Z., Zhang, X., Zhang, L., Liu, W.L., Feng, Y., Guo, B.H., Mai, H.Q., Cao, S.M., Li, M.Z., Qin, H.D., Zeng, Y.X., Zeng, M.S. Clin. Cancer Res. (2007) [Pubmed]
  9. RNAi knockdown of human kinetochore protein CENP-H. Orthaus, S., Ohndorf, S., Diekmann, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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