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Psmd9  -  proteasome (prosome, macropain) 26S...

Mus musculus

Synonyms: 1500011J20Rik, 2610202L11Rik, 26S proteasome non-ATPase regulatory subunit 9, 26S proteasome regulatory subunit p27, Bridge-1, ...
 
 
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High impact information on Psmd9

 

Biological context of Psmd9

 

Anatomical context of Psmd9

  • In Staggerer, however, neuraminidase peak activity was observed at P27 in the cerebellum, whereas the activity was close to normal in Staggerer cerebrum and liver [7].
  • We examined the ability of its two major forms of 38 (P38) and 27 (P27) amino acid residues to cross the murine blood-brain barrier [8].
  • P27 kept its antigenicity after incorporation in ISCOMs, which induced, after iterative intubations by the oral route to groups of mice, a systemic IgG response, a local IgA response, and a local enhanced cellular response as demonstrated by lymphoproliferation of mesenteric lymph node cells upon in vitro stimulation with antigen [9].
  • Immunostimulating complexes (ISCOMs) were built after treatment of a purified surface protein from Eimeria falciformis sporozoites with a palmitic acid derivation, leading to a high ratio (33-64%) of P27 incorporation in these cage-like structures [9].
  • By immunoblot analysis, mouse anti-recombinant P27/30 serum reacted with major constituent protein bands in extracts of adult ticks, and also immunoreacted with muscle, cuticle, gut, and salivary gland in H. longicornis ticks [6].
 

Associations of Psmd9 with chemical compounds

  • D1 dopamine receptor regulation of the levels of the cell-cycle-controlling proteins, cyclin D, P27 and Raf-1, in cerebral cortical precursor cells is mediated through cAMP-independent pathways [3].
  • Paradoxically, revascularization was markedly accelerated and neovascularization markedly reduced in mice maintained in prolonged hyperoxia (P7-P27) compared with mice recovering in room air [10].
 

Analytical, diagnostic and therapeutic context of Psmd9

  • All mAbs bound to the same immunoaffinity-purified antigens in Western-blot analysis (P27 for E. falciformis and P25 for E. tenella and E. acervulina) [11].
  • Moreover, immunohistochemistry using the anti-P27/30 serum showed a strong reactivity in muscle, suggesting that native P27/30 is expressed abundantly in that tissue [6].

References

  1. Mechanisms of energy restriction: effects of corticosterone on cell growth, cell cycle machinery, and apoptosis. Jiang, W., Zhu, Z., Bhatia, N., Agarwal, R., Thompson, H.J. Cancer Res. (2002) [Pubmed]
  2. Overexpression of the coactivator bridge-1 results in insulin deficiency and diabetes. Volinic, J.L., Lee, J.H., Eto, K., Kaur, V., Thomas, M.K. Mol. Endocrinol. (2006) [Pubmed]
  3. D1 dopamine receptor regulation of the levels of the cell-cycle-controlling proteins, cyclin D, P27 and Raf-1, in cerebral cortical precursor cells is mediated through cAMP-independent pathways. Zhang, L., Bai, J., Undie, A.S., Bergson, C., Lidow, M.S. Cereb. Cortex (2005) [Pubmed]
  4. P27 knockout mice: reduced myostatin in muscle and altered adipogenesis. Lin, J., Della-Fera, M.A., Li, C., Page, K., Choi, Y.H., Hartzell, D.L., Baile, C.A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  5. The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis. Bigi, F., Gioffré, A., Klepp, L., de la Paz Santangelo, M., Alito, A., Caimi, K., Meikle, V., Zumárraga, M., Taboga, O., Romano, M.I., Cataldi, A. Microbes Infect. (2004) [Pubmed]
  6. Molecular characterization of a troponin I-like protein from the hard tick Haemaphysalis longicornis. You, M., Xuan, X., Tsuji, N., Kamio, T., Igarashi, I., Nagasawa, H., Mikami, T., Fujisaki, K. Insect Biochem. Mol. Biol. (2001) [Pubmed]
  7. Changes in particulate neuraminidase activity during normal and staggerer mutant mouse development. Wille, W., Trenkner, E. J. Neurochem. (1981) [Pubmed]
  8. Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38 across the blood-brain barrier. Banks, W.A., Kastin, A.J., Komaki, G., Arimura, A. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  9. Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeria falciformis in ISCOMs. Kazanji, M., Laurent, F., Péry, P. Vaccine (1994) [Pubmed]
  10. Effects of sustained hyperoxia on revascularization in experimental retinopathy of prematurity. Gu, X., Samuel, S., El-Shabrawey, M., Caldwell, R.B., Bartoli, M., Marcus, D.M., Brooks, S.E. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  11. Production and characterization of monoclonal antibodies directed against Eimeria falciformis and cross-reactive with sporozoites from two species of avian coccidia. Kazanji, M., Rhalem, A., Péry, P. Parasitol. Res. (1994) [Pubmed]
 
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