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Gene Review

Slc38a2  -  solute carrier family 38, member 2

Mus musculus

Synonyms: 5033402L14Rik, AI316867, ATA2, Amino acid transporter A2, Ata2, ...
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Disease relevance of Slc38a2


High impact information on Slc38a2

  • Decreasing fetal demand genetically by removal of fetal Igf2 abolished up-regulation of both transport systems and reduced placental System A amino acid transport activity and expression of Slc38a2 in late gestation [2].
  • Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells [3].
  • Here we demonstrate that insulin induces an increase in the plasma membrane abundance of SAT2 in a phosphatidylinositol 3-kinase-dependent manner and that this increase is derived from an endosomal compartment that is required for the hormonal activation of System A [3].
  • Our data indicate strongly that insulin increases System A transport in L6 cells by stimulating the exocytosis of SAT2 carriers from a chloroquine-sensitive endosomal compartment [3].
  • The failure to stimulate System A and recruit SAT2 to the cell surface could not be attributed to a block in insulin signaling, as chloroquine had no effect on the insulin-mediated phosphorylation of protein kinase B or glycogen synthase kinase 3 or upon insulin-stimulated GLUT4 translocation and glucose transport [3].

Biological context of Slc38a2

  • These studies provide the first evidence regarding the subcellular distribution and adaptive up-regulation of SAT2 protein and the characterization of molecular probes for this physiologically important transporter, the function of which is altered in several disease states [4].

Anatomical context of Slc38a2


Other interactions of Slc38a2


Analytical, diagnostic and therapeutic context of Slc38a2

  • Binding of the MAbs to 73 SAT 2 field isolates was measured in a sandwich ELISA and defined four distinct antigenic regions [1].


  1. Characterization of monoclonal antibodies against a type SAT 2 foot-and-mouth disease virus. Crowther, J.R., Rowe, C.A., Butcher, R. Epidemiol. Infect. (1993) [Pubmed]
  2. Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Constância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C.P., Reik, W., Fowden, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. Hyde, R., Peyrollier, K., Hundal, H.S. J. Biol. Chem. (2002) [Pubmed]
  4. Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes. Hyde, R., Christie, G.R., Litherland, G.J., Hajduch, E., Taylor, P.M., Hundal, H.S. Biochem. J. (2001) [Pubmed]
  5. Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons. Dolińska, M., Zabłocka, B., Sonnewald, U., Albrecht, J. Neurochem. Int. (2004) [Pubmed]
  6. Evaluation of techniques to demonstrate foot-and-mouth disease virus in bovine tongue epithelium: comparison of the sensitivity of cattle, mice, primary cell cultures, cryopreserved cell cultures and established cell lines. House, C., House, J.A. Vet. Microbiol. (1989) [Pubmed]
  7. Selection of vaccine strains of foot and mouth disease virus for use in southern Africa. Fargeaud, D. Rev. - Off. Int. Epizoot. (1995) [Pubmed]
  8. Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2. Hatanaka, T., Hatanaka, Y., Setou, M. J. Biol. Chem. (2006) [Pubmed]
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