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Gene Review

SULT2B1  -  sulfotransferase family, cytosolic, 2B,...

Homo sapiens

Synonyms: Alcohol sulfotransferase, HSST2, Hydroxysteroid sulfotransferase 2, ST2B1, Sulfotransferase 2B1, ...
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Disease relevance of SULT2B1

  • This fluorometric assay was used to determine the activities of AST as purified form and in crude extracts of pig liver, rat liver, and Escherichia coli [1].

High impact information on SULT2B1

  • The gene for human hydroxysteroid sulfotransferase (SULT2B1) encodes two peptides, SULT2B1a and SULT2B1b, that differ only at their amino termini [2].
  • In addition, the amino-terminal helix comprising residues Asp19 to Lys26, which determines the specificity difference between the SULT2B1 isoforms, becomes ordered upon pregnenolone binding, covering the substrate binding pocket [2].
  • Thus, if the gene for SULT2B1 employs exon 1B, cholesterol sulfotransferase is synthesized, whereas if exon 1A is used, pregnenolone sulfotransferase is produced [3].
  • cDNAs for rat SULT2B1 steroid/sterol sulfotransferase isoforms were cloned, and the encoded proteins overexpressed, purified and characterized [4].
  • Cloning, characterization and tissue expression of rat SULT2B1a and SULT2B1b steroid/sterol sulfotransferase isoforms: divergence of the rat SULT2B1 gene structure from orthologous human and mouse genes [4].

Biological context of SULT2B1


Anatomical context of SULT2B1


Associations of SULT2B1 with chemical compounds


Other interactions of SULT2B1

  • The outstanding structural feature that distinguishes the SULT2B1 isoforms from the prototypical SULT2A1 isozyme is the presence of extended amino- and carboxyl-terminal ends in the former [3].
  • The recombinant PST did not use the alcohol substrate under the designed condition, and the sensitivity for AST activity was found to be comparable to that of radioactive assay as reported in the literature [1].
  • SULT1C2 expression was abundant in all cell types, whereas that of SULT1E1, SULTIBI or SULT2B1 was restricted to a specific cell type [11].

Analytical, diagnostic and therapeutic context of SULT2B1


  1. Fluorometric assay for alcohol sulfotransferase. Chen, W.T., Liu, M.C., Yang, Y.S. Anal. Biochem. (2005) [Pubmed]
  2. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. Lee, K.A., Fuda, H., Lee, Y.C., Negishi, M., Strott, C.A., Pedersen, L.C. J. Biol. Chem. (2003) [Pubmed]
  3. Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. Fuda, H., Lee, Y.C., Shimizu, C., Javitt, N.B., Strott, C.A. J. Biol. Chem. (2002) [Pubmed]
  4. Cloning, characterization and tissue expression of rat SULT2B1a and SULT2B1b steroid/sterol sulfotransferase isoforms: divergence of the rat SULT2B1 gene structure from orthologous human and mouse genes. Kohjitani, A., Fuda, H., Hanyu, O., Strott, C.A. Gene (2006) [Pubmed]
  5. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. Her, C., Wood, T.C., Eichler, E.E., Mohrenweiser, H.W., Ramagli, L.S., Siciliano, M.J., Weinshilboum, R.M. Genomics (1998) [Pubmed]
  6. Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). Meloche, C.A., Falany, C.N. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  7. Biochemical characterization and tissue distribution of human SULT2B1. Geese, W.J., Raftogianis, R.B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  8. Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Sakakibara, Y., Yanagisawa, K., Takami, Y., Nakayama, T., Suiko, M., Liu, M.C. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  9. Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung. He, D., Frost, A.R., Falany, C.N. Biochim. Biophys. Acta (2005) [Pubmed]
  10. Human cytosolic sulfotransferase 2B1: Isoform expression, tissue specificity and subcellular localization. Falany, C.N., He, D., Dumas, N., Frost, A.R., Falany, J.L. J. Steroid Biochem. Mol. Biol. (2006) [Pubmed]
  11. Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues. Tamura, H.O., Taniguchi, K., Hayashi, E., Hiyoshi, Y., Nagai, F. Biol. Pharm. Bull. (2001) [Pubmed]
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