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Gene Review

COLEC12  -  collectin sub-family member 12

Homo sapiens

Synonyms: CL-P1, CLP1, Collectin placenta protein 1, Collectin-12, NSR2, ...
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Disease relevance of COLEC12


High impact information on COLEC12


Biological context of COLEC12

  • Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene [5].
  • By sequencing the CL-P1 gene in ten Japanese volunteers, we identified five single-nucleotide polymorphisms (SNPs) with a minor allele frequency of at least 29% [5].
  • The clp1 transcript was normally detected only in the presence of the A protein heterodimer formed when homokaryons with compatible A genes were mated [4].
  • Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor [6].
  • Moreover, we suggest that this complex represents a stabilized ATP bound form of Clp1 that requires the participation of other non-CFIA processing factors in order to initiate timely ATP hydrolysis during 3' end processing [6].

Anatomical context of COLEC12

  • When hSRCL type I and type II were expressed in CHO-K1 cells, they were localized in the plasma membrane forming clusters on the surface [1].
  • We show that scavenger receptor with C-type lectin (SRCL), a member of the scavenger receptor family containing coiled-coil, collagen-like, and C-type lectin/carbohydrate recognition domains, is expressed in cultured astrocytes and microglia [7].
  • Thus, Gfi1 selectively specifies IL7-dependent development of B cells from CLP1 progenitors, providing clues to the transcriptional networks integrating cytokine signals and lymphoid differentiation [8].

Associations of COLEC12 with chemical compounds

  • After PSP bolus injection, CLR and CLP were 252.8 +/- 57.9 and 350.0 +/- 41.3 mL/min/1.73 m2, respectively [9].
  • Therefore, we conclude that CLP is a trypsin-like serine protease [10].
  • The crystal structures of gamma-carboxyglutamic acid domains of coagulation factors X and IX have recently been clarified in structural studies of complexes between the gamma-carboxyglutamic acid domain of factors X and X-bp (a venom CLP) and between the gamma-carboxyglutamic acid domain of factors IX and IX-bp (a venom CLP) [11].

Analytical, diagnostic and therapeutic context of COLEC12

  • Northern blot analysis revealed that hSRCL type I and type II mRNAs are abundantly expressed in adult human tissues [1].
  • Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family [1].
  • An approximately 2.1-fold increase in immunofluorescence intensity was observed for the SRCL transfectants compared to control vector transfectants [2].
  • 293/EBNA-1 cells stably expressing SRCL were found to take up GalNAc but not mannose-conjugated particles on confocal microscopy [2].


  1. Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. Nakamura, K., Funakoshi, H., Miyamoto, K., Tokunaga, F., Nakamura, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen. Yoshida, T., Tsuruta, Y., Iwasaki, M., Yamane, S., Ochi, T., Suzuki, R. J. Biochem. (2003) [Pubmed]
  3. Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands. Coombs, P.J., Graham, S.A., Drickamer, K., Taylor, M.E. J. Biol. Chem. (2005) [Pubmed]
  4. The clp1 gene of the mushroom Coprinus cinereus is essential for A-regulated sexual development. Inada, K., Morimoto, Y., Arima, T., Murata, Y., Kamada, T. Genetics (2001) [Pubmed]
  5. Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene. Ohmori, H., Makita, Y., Funamizu, M., Chiba, S., Ohtani, K., Suzuki, Y., Wakamiya, N., Hata, A. J. Hum. Genet. (2003) [Pubmed]
  6. Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor. Noble, C.G., Beuth, B., Taylor, I.A. Nucleic Acids Res. (2007) [Pubmed]
  7. Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease. Nakamura, K., Ohya, W., Funakoshi, H., Sakaguchi, G., Kato, A., Takeda, M., Kudo, T., Nakamura, T. J. Neurosci. Res. (2006) [Pubmed]
  8. Transcriptional repressor gfi1 integrates cytokine-receptor signals controlling B-cell differentiation. Rathinam, C., Klein, C. PLoS ONE (2007) [Pubmed]
  9. Evaluation of two intravenous single-bolus methods for measuring effective renal plasma flow. Hirata-Dulas, C.A., Awni, W.M., Matzke, G.R., Halstenson, C.E., Guay, D.R. Am. J. Kidney Dis. (1994) [Pubmed]
  10. A fibrinolytic enzyme from a marine green alga, Codium latum. Matsubara, K., Hori, K., Matsuura, Y., Miyazawa, K. Phytochemistry (1999) [Pubmed]
  11. Structure-function relationships of C-type lectin-related proteins. Morita, T. Pathophysiol. Haemost. Thromb. (2005) [Pubmed]
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