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Chemical Compound Review

Sulphental     4-[9-(4-hydroxyphenyl)-7,7- dioxo-8-oxa...

Synonyms: Fenolipuna, Sulphonthal, Sulfonphthal, PHENOL RED, CHEMBL258921, ...
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Disease relevance of PHENOL RED


Psychiatry related information on PHENOL RED


High impact information on PHENOL RED

  • Consistent with previous reports (Linsley, P. S., P. M. Wallace, J. Johnson, M. G. Gibson, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Science (Wash. DC). 257:792), T cell-dependent antibody production was profoundly inhibited in mCTLA4-H gamma 1 transgenic mice immunized with a protein antigen [7].
  • Flow of intestinal contents was measured by indicator (phenolsulfonphthalein) dilution over a 20-cm segment; flow was related to motility at the perfusion site [8].
  • Previous work has shown that actin binds specifically and saturably to liver membranes stripped of endogenous actin (Tranter, M. P., S. P. Sugrue, and M. A. Schwartz. 1989. J. Cell Biol. 109:2833-2840) [9].
  • We have isolated two bisphenolic compounds (4 and 5) that have a marked effect on K+ and Na+ concentrations in human cells from commercial preparations of the pH indicator dye phenol red (phenolsulfonphthalein) [10].
  • The coefficient of correlation between lysozyme concentration and the 15-min excretion rate of phenolsulfonphthalein (r = -0.70) was higher than that between beta 2-microglobulin concentration and the 15-min excretion rate of phenolsulfonphthalein (r = -0.46) [11].

Biological context of PHENOL RED


Anatomical context of PHENOL RED


Associations of PHENOL RED with other chemical compounds


Gene context of PHENOL RED

  • The concentrations of lysozyme and beta 2-microglobulin in urine increased in proportion to the decrease in the rate of excretion of phenolsulfonphthalein in these patients [11].
  • After PSP bolus injection, CLR and CLP were 252.8 +/- 57.9 and 350.0 +/- 41.3 mL/min/1.73 m2, respectively [12].
  • Phenol Red (phenolsulphonphthalein, PSP; 0.5 and 1 mmol l(-)(1)) slowed the FSR and abolished stimulation of the FSR by cAMP [25].
  • Group A showed significantly more severe hematuria (p < 0.05) than group B. Group A showed a significant decrease in glomerular filtration rate (GFR; p < 0.05): the mean values being 60.8 +/- 39 in group A and 94.5 +/- 32 ml/min in group B. Group A showed a significant decrease in the phenolsulfonphthalein excretion test (p < 0.05) [26].
  • At 90 minutes reperfusion the PR clearance showed 0.11 +/- 0.01 and 0.11 +/- 0.02 mg/30min/g-liver and the TC clearance 1.01 +/- 0.10 and 1.01 +/- 0.07 micromol/ml/30min/g-liver in the IPL and IdPL, respectively [27].

Analytical, diagnostic and therapeutic context of PHENOL RED


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  9. Binding of actin to liver cell membranes: the state of membrane-bound actin. Tranter, M.P., Sugrue, S.P., Schwartz, M.A. J. Cell Biol. (1991) [Pubmed]
  10. Bisphenolic compounds that enhance cell cation transport are found in commercial phenol red. Kym, P.R., Hummert, K.L., Nilsson, A.G., Lubin, M., Katzenellenbogen, J.A. J. Med. Chem. (1996) [Pubmed]
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  14. Physiologically based pharmacokinetic model for the renal clearance of salicyluric acid and the interaction with phenolsulfonphthalein in the dog. Russel, F.G., Wouterse, A.C., van Ginneken, C.A. Drug Metab. Dispos. (1987) [Pubmed]
  15. Pharmacokinetic analysis of the absorption enhancing action of decanoic acid and its derivatives in rats. Takahashi, K., Murakami, T., Kamata, A., Yumoto, R., Higashi, Y., Yata, N. Pharm. Res. (1994) [Pubmed]
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  17. Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs. Tanaka, T., Mizumoto, A., Mochiki, E., Suzuki, H., Itoh, Z., Omura, S. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  18. Phenolsulfonphthalein transport by potential-sensitive urate transport system. Itagaki, S., Shimamoto, S., Sugawara, M., Kobayashi, M., Miyazaki, K., Hirano, T., Iseki, K. Eur. J. Pharmacol. (2005) [Pubmed]
  19. Elimination of phenolsulfonphthalein from the cerebrospinal fluid via capillaries in central nervous system in cats by active transport. Zmajević, M., Klarica, M., Varda, R., Kudelić, N., Bulat, M. Neurosci. Lett. (2002) [Pubmed]
  20. Protective action of diethyldithiocarbamate and carbon disulfide against renal injury induced by chloroform in mice. Masuda, Y., Nakayama, N. Biochem. Pharmacol. (1983) [Pubmed]
  21. Effect of surfactants on absorption through membranes IV: effects of dioctyl sodium sulfosuccinate on absorption of a poorly absorbable drug, phenolsulfonphthalein, in humans. Khalafallah, N., Gouda, M.W., Khalil, S.A. Journal of pharmaceutical sciences. (1975) [Pubmed]
  22. Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Sakurai, Y., Motohashi, H., Ueo, H., Masuda, S., Saito, H., Okuda, M., Mori, N., Matsuura, M., Doi, T., Fukatsu, A., Ogawa, O., Inui, K. Pharm. Res. (2004) [Pubmed]
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  26. Significance of glomerular deposition of plasmin-alpha 2-plasmin inhibitor complexes in various glomerulopathies. Suzuki, S., Sato, H., Shimada, H., Takashima, N., Kishimoto, H., Ueno, M., Nishi, S., Wada, K., Takahashi, H., Shibata, A. Clin. Nephrol. (1993) [Pubmed]
  27. Development of the isolated dual perfused rat liver model as an improved reperfusion model for transplantation research. 't Hart, N.A., van der Plaats, A., Moers, C., Leuvenink, H.G., Wiersema-Buist, J., Verkerke, G.J., Rakhorst, G., Ploeg, R.J. The International journal of artificial organs. (2006) [Pubmed]
  28. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer. Yoshida, S., Matsui, M., Shirouzu, Y., Fujita, H., Yamana, H., Shirouzu, K. Ann. Surg. (1998) [Pubmed]
  29. Tetraethylammonium induced coronary spasm in isolated perfused rabbit heart: a hypothesis for the mechanism of coronary spasm. Iwaki, M., Mizobuchi, S., Nakaya, Y., Kawano, K., Niki, T., Mori, H. Cardiovasc. Res. (1987) [Pubmed]
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