Gene Review:
Lss - lanosterol synthase (2,3-oxidosqualene...
Rattus norvegicus
Synonyms:
2,3-epoxysqualene--lanosterol cyclase, Lanosterol synthase, OSC, Osc, Oxidosqualene--lanosterol cyclase
- Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. Mori, M., Li, G., Abe, I., Nakayama, J., Guo, Z., Sawashita, J., Ugawa, T., Nishizono, S., Serikawa, T., Higuchi, K., Shumiya, S. J. Clin. Invest. (2006)
- Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA. Abe, I., Prestwich, G.D. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Active site mapping of affinity-labeled rat oxidosqualene cyclase. Abe, I., Prestwich, G.D. J. Biol. Chem. (1994)
- Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. Barth, M.M., Binet, J.L., Thomas, D.M., de Fornel, D.C., Samreth, S., Schuber, F.J., Renaut, P.P. J. Med. Chem. (1996)
- Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles. Brown, G.R., Hollinshead, D.M., Stokes, E.S., Clarke, D.S., Eakin, M.A., Foubister, A.J., Glossop, S.C., Griffiths, D., Johnson, M.C., McTaggart, F., Mirrlees, D.J., Smith, G.J., Wood, R. J. Med. Chem. (1999)
- Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. Stach, D., Zheng, Y.F., Perez, A.L., Oehlschlager, A.C., Abe, I., Prestwich, G.D., Hartman, P.G. J. Med. Chem. (1997)
- Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. Viola, F., Brusa, P., Balliano, G., Ceruti, M., Boutaud, O., Schuber, F., Cattel, L. Biochem. Pharmacol. (1995)