Gene Review:
Fdft1 - farnesyl diphosphate farnesyl transferase 1
Rattus norvegicus
Synonyms:
FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, SQS, SS, Squalene synthase
- Differences in the effects of membrane depolarization on levels of preprosomatostatin mRNA and tyrosine hydroxylase mRNA in rat sympathetic neurons in vivo and in culture. Spiegel, K., Kremer, N.E., Kessler, J.A. Brain Res. Mol. Brain Res. (1989)
- Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. Mori, M., Li, G., Abe, I., Nakayama, J., Guo, Z., Sawashita, J., Ugawa, T., Nishizono, S., Serikawa, T., Higuchi, K., Shumiya, S. J. Clin. Invest. (2006)
- Squalene synthase: structure and regulation. Tansey, T.R., Shechter, I. Prog. Nucleic Acid Res. Mol. Biol. (2001)
- Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. Doerner, K.C., Gurley, E.C., Vlahcevic, Z.R., Hylemon, P.B. J. Lipid Res. (1995)
- Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. Brown, G.R., Clarke, D.S., Foubister, A.J., Freeman, S., Harrison, P.J., Johnson, M.C., Mallion, K.B., McCormick, J., McTaggart, F., Reid, A.C., Smith, G.J., Taylor, M.J. J. Med. Chem. (1996)
- The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. Chan, C., Andreotti, D., Cox, B., Dymock, B.W., Hutson, J.L., Keeling, S.E., McCarthy, A.D., Procopiou, P.A., Ross, B.C., Sareen, M., Scicinski, J.J., Sharratt, P.J., Snowden, M.A., Watson, N.S. J. Med. Chem. (1996)
- HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. Petras, S.F., Lindsey, S., Harwood, H.J. J. Lipid Res. (1999)
- Inhibition of squalene synthase in vitro by 3-(biphenyl-4-yl)-quinuclidine. Ward, W.H., Holdgate, G.A., Freeman, S., McTaggart, F., Girdwood, P.A., Davidson, R.G., Mallion, K.B., Brown, G.R., Eakin, M.A. Biochem. Pharmacol. (1996)
- Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase. Shechter, I., Klinger, E., Rucker, M.L., Engstrom, R.G., Spirito, J.A., Islam, M.A., Boettcher, B.R., Weinstein, D.B. J. Biol. Chem. (1992)
- Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase. Ericsson, J., Appelkvist, E.L., Thelin, A., Chojnacki, T., Dallner, G. J. Biol. Chem. (1992)
- Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-coa reductase inhibitors. Hiyoshi, H., Yanagimachi, M., Ito, M., Ohtsuka, I., Yoshida, I., Saeki, T., Tanaka, H. J. Lipid Res. (2000)
- Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. Hiyoshi, H., Yanagimachi, M., Ito, M., Yasuda, N., Okada, T., Ikuta, H., Shinmyo, D., Tanaka, K., Kurusu, N., Yoshida, I., Abe, S., Saeki, T., Tanaka, H. J. Lipid Res. (2003)
- Amygdaloid kindling of rats increases preprosomatostatin mRNA and somatostatin without affecting glutamic acid decarboxylase (GAD) mRNA or GAD. Shinoda, H., Schwartz, J.P., Nadi, N.S. Brain Res. Mol. Brain Res. (1989)
- Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation. Lindsey, S., Harwood, H.J. J. Biol. Chem. (1995)
- Chromosomal localization of genes involved in biosynthesis, metabolism or transport of cholesterol in the rat. Bonné, A.C., den Bieman, M.G., Gillissen, G.F., van Lith, H.A., van Zutphen, L.F. Cytogenet. Genome Res. (2002)
- Determination of isopentenyl diphosphate and farnesyl diphosphate in tissue samples with a comment on secondary regulation of polyisoprenoid biosynthesis. Bruenger, E., Rilling, H.C. Anal. Biochem. (1988)
- Effects of AP-V and bicuculline on somatostatin-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia. Fan, X.T., Ruan, H.Z., Xu, H.W., Zhang, J.H., Wu, X.G. Acta Pharmacol. Sin. (2001)