Gene Review:
RANBP2 - RAN binding protein 2
Homo sapiens
Synonyms:
358 kDa nucleoporin, ADANE, ANE1, E3 SUMO-protein ligase RanBP2, IIAE3, ...
- Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Mavlyutov, T.A., Cai, Y., Ferreira, P.A. Traffic (2002)
- An autologous oral DNA vaccine protects against murine melanoma. Xiang, R., Lode, H.N., Chao, T.H., Ruehlmann, J.M., Dolman, C.S., Rodriguez, F., Whitton, J.L., Overwijk, W.W., Restifo, N.P., Reisfeld, R.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Efficient amplification of melanoma-specific CD8+ T cells using artificial antigen presenting complex. Chang, J. Exp. Mol. Med. (2006)
- The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Pichler, A., Gast, A., Seeler, J.S., Dejean, A., Melchior, F. Cell (2002)
- A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Mahajan, R., Delphin, C., Guan, T., Gerace, L., Melchior, F. Cell (1997)
- Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. Ferreira, P.A., Nakayama, T.A., Pak, W.L., Travis, G.H. Nature (1996)
- RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. Swaminathan, S., Kiendl, F., Körner, R., Lupetti, R., Hengst, L., Melchior, F. J. Cell Biol. (2004)
- The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. Singh, B.B., Patel, H.H., Roepman, R., Schick, D., Ferreira, P.A. J. Biol. Chem. (1999)
- GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358. Yaseen, N.R., Blobel, G. J. Biol. Chem. (1999)
- The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. Kirsh, O., Seeler, J.S., Pichler, A., Gast, A., Müller, S., Miska, E., Mathieu, M., Harel-Bellan, A., Kouzarides, T., Melchior, F., Dejean, A. EMBO J. (2002)
- Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Zhang, H., Saitoh, H., Matunis, M.J. Mol. Cell. Biol. (2002)
- Nup358 integrates nuclear envelope breakdown with kinetochore assembly. Salina, D., Enarson, P., Rattner, J.B., Burke, B. J. Cell Biol. (2003)
- Parkin ubiquitinates and promotes the degradation of RanBP2. Um, J.W., Min, d.o. .S., Rhim, H., Kim, J., Paik, S.R., Chung, K.C. J. Biol. Chem. (2006)
- Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. Wu, J., Matunis, M.J., Kraemer, D., Blobel, G., Coutavas, E. J. Biol. Chem. (1995)
- Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210. Favreau, C., Worman, H.J., Wozniak, R.W., Frappier, T., Courvalin, J.C. Biochemistry (1996)
- Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity. Doyle, H.A., Zhou, J., Wolff, M.J., Harvey, B.P., Roman, R.M., Gee, R.J., Koski, R.A., Mamula, M.J. J. Biol. Chem. (2006)
- Role of proline residues in the expression and function of the human noradrenaline transporter. Paczkowski, F.A., Bryan-Lluka, L.J. J. Neurochem. (2004)
- RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Forler, D., Rabut, G., Ciccarelli, F.D., Herold, A., Köcher, T., Niggeweg, R., Bork, P., Ellenberg, J., Izaurralde, E. Mol. Cell. Biol. (2004)
- Solution structure of the Ran-binding domain 2 of RanBP2 and its interaction with the C terminus of Ran. Geyer, J.P., Döker, R., Kremer, W., Zhao, X., Kuhlmann, J., Kalbitzer, H.R. J. Mol. Biol. (2005)
- Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta. Villa Braslavsky, C.I., Nowak, C., Görlich, D., Wittinghofer, A., Kuhlmann, J. Biochemistry (2000)
- The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type. Pichler, A., Knipscheer, P., Saitoh, H., Sixma, T.K., Melchior, F. Nat. Struct. Mol. Biol. (2004)
- Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor. Ma, Z., Hill, D.A., Collins, M.H., Morris, S.W., Sumegi, J., Zhou, M., Zuppan, C., Bridge, J.A. Genes Chromosomes Cancer (2003)
- Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12. Nothwang, H.G., Rensing, C., Kübler, M., Denich, D., Brandl, B., Stubanus, M., Haaf, T., Kurnit, D., Hildebrandt, F. Genomics (1998)
- A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. Kehlenbach, R.H., Dickmanns, A., Kehlenbach, A., Guan, T., Gerace, L. J. Cell Biol. (1999)
- Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. Miyauchi, Y., Yogosawa, S., Honda, R., Nishida, T., Yasuda, H. J. Biol. Chem. (2002)
- RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Delphin, C., Guan, T., Melchior, F., Gerace, L. Mol. Biol. Cell (1997)
- Inhibitory effect of the polyinosinic-polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma. Fujimura, T., Nakagawa, S., Ohtani, T., Ito, Y., Aiba, S. Eur. J. Immunol. (2006)
- An altered peptide ligand for na??ve cytotoxic T lymphocyte epitope of TRP-2((180-188)) enhanced immunogenicity. Tang, Y., Lin, Z., Ni, B., Wei, J., Han, J., Wang, H., Wu, Y. Cancer Immunol. Immunother. (2007)