Gene Review:
HAP1 - Hap1p
Saccharomyces cerevisiae S288c
Synonyms:
CYP1, CYP1 activatory protein, Heme activator protein 1, Heme-responsive zinc finger transcription factor HAP1, L9672.1, ...
- Functional dissection and sequence of yeast HAP1 activator. Pfeifer, K., Kim, K.S., Kogan, S., Guarente, L. Cell (1989)
- Yeast HAP1 activator binds to two upstream activation sites of different sequence. Pfeifer, K., Prezant, T., Guarente, L. Cell (1987)
- Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene. Pfeifer, K., Arcangioli, B., Guarente, L. Cell (1987)
- Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI. Kim, K.S., Guarente, L. Nature (1989)
- Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins: a binding site for the HAP1 (CYP1) protein in the UAS region of the yeast catalase T gene (CTT1). Winkler, H., Adam, G., Mattes, E., Schanz, M., Hartig, A., Ruis, H. EMBO J. (1988)
- Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein. King, D.A., Zhang, L., Guarente, L., Marmorstein, R. Nat. Struct. Biol. (1999)
- Internal deletions in the yeast transcriptional activator HAP1 have opposite effects at two sequence elements. Kim, K.S., Pfeifer, K., Powell, L., Guarente, L. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Heme binds to a short sequence that serves a regulatory function in diverse proteins. Zhang, L., Guarente, L. EMBO J. (1995)
- Inducibility of the response of yeast cells to peroxide stress. Collinson, L.P., Dawes, I.W. J. Gen. Microbiol. (1992)
- Effects of hap mutations on heme and cytochrome formation in yeast. Mattoon, J.R., Caravajal, E., Guthrie, D. Curr. Genet. (1990)
- A novel allele of HAP1 causes uninducible expression of HEM13 in Saccharomyces cerevisiae. Ushinsky, S.C., Keng, T. Genetics (1994)
- Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Zitomer, R.S., Lowry, C.V. Microbiol. Rev. (1992)
- The C6 zinc cluster dictates asymmetric binding by HAP1. Zhang, L., Guarente, L. EMBO J. (1996)
- Proline utilization in Saccharomyces cerevisiae: sequence, regulation, and mitochondrial localization of the PUT1 gene product. Wang, S.S., Brandriss, M.C. Mol. Cell. Biol. (1987)
- Regulation of the Saccharomyces cerevisiae DLD1 gene encoding the mitochondrial protein D-lactate ferricytochrome c oxidoreductase by HAP1 and HAP2/3/4/5. Lodi, T., Alberti, A., Guiard, B., Ferrero, I. Mol. Gen. Genet. (1999)
- Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4. Schneider, J.C., Guarente, L. Mol. Cell. Biol. (1991)
- The yeast activator HAP1--a GAL4 family member--binds DNA in a directly repeated orientation. Zhang, L., Guarente, L. Genes Dev. (1994)
- CYP1 (HAP1) is a determinant effector of alternative expression of heme-dependent transcribed genes in yeast [corrected]. Verdière, J., Gaisne, M., Labbe-Bois, R. Mol. Gen. Genet. (1991)
- Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1. Lee, H.C., Hon, T., Lan, C., Zhang, L. Mol. Cell. Biol. (2003)
- The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Hon, T., Lee, H.C., Hach, A., Johnson, J.L., Craig, E.A., Erdjument-Bromage, H., Tempst, P., Zhang, L. Mol. Cell. Biol. (2001)
- Regulation of the CYB2 gene expression: transcriptional co-ordination by the Hap1p, Hap2/3/4/5p and Adr1p transcription factors. Ramil, E., Agrimonti, C., Shechter, E., Gervais, M., Guiard, B. Mol. Microbiol. (2000)
- Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Monteiro, G., Pereira, G.A., Netto, L.E. Free Radic. Biol. Med. (2002)
- Positive and negative transcriptional control by heme of genes encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae. Thorsness, M., Schafer, W., D'Ari, L., Rine, J. Mol. Cell. Biol. (1989)
- Transcriptional regulation of the two sterol esterification genes in the yeast Saccharomyces cerevisiae. Jensen-Pergakes, K., Guo, Z., Giattina, M., Sturley, S.L., Bard, M. J. Bacteriol. (2001)
- A microarray-assisted screen for potential Hap1 and Rox1 target genes in Saccharomyces cerevisiae. Ter Linde, J.J., Steensma, H.Y. Yeast (2002)
- Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. Wilcox, L.J., Balderes, D.A., Wharton, B., Tinkelenberg, A.H., Rao, G., Sturley, S.L. J. Biol. Chem. (2002)
- HAP1 is nuclear but is bound to a cellular factor in the absence of heme. Zhang, L., Guarente, L. J. Biol. Chem. (1994)