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Gene Review

PSA1  -  mannose-1-phosphate guanylyltransferase

Saccharomyces cerevisiae S288c

Synonyms: ATP-mannose-1-phosphate guanylyltransferase, GDP-mannose pyrophosphorylase, MPG1, Mannose-1-phosphate guanyltransferase, NDP-hexose pyrophosphorylase, ...
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Disease relevance of PSA1


High impact information on PSA1


Chemical compound and disease context of PSA1

  • We examined the enzyme activity of a glutathione S-transferase fusion of each VIG9 gene to synthesize GDP mannose in the cell extracts of a heterologous Escherichia coli expression system [5].

Biological context of PSA1


Anatomical context of PSA1

  • These results suggest that greater exposure of flocculin on the cell surface, caused by either cell wall distortion (through depletion of Pkc1p) or aberrant regulation of mannosylation (through constitutive production of Srb1p), results in an increased flocculation ability [8].

Associations of PSA1 with chemical compounds


Other interactions of PSA1

  • In the alg1 and alg2 mutants, complemented with MPG1 gene, N-glycosylation of invertase was in part restored, to a degree comparable to that of the wild-type control [13].
  • A plasmid suppressor of alg1, PSA1, encodes a 361 amino-acid protein with homology to NDP-hexose pyrophosphorylases, the enzymes that catalyze the formation of activated sugar nucleotides [9].
  • The autonomously replicating plasmid YEpSS1, containing the S. cerevisiae SOD1 and SRB1 genes, was highly unstable in a wild-type strain [14].


  1. Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation. Hashimoto, H., Sakakibara, A., Yamasaki, M., Yoda, K. J. Biol. Chem. (1997) [Pubmed]
  2. Defect in cell wall integrity of the yeast saccharomyces cerevisiae caused by a mutation of the GDP-mannose pyrophosphorylase gene VIG9. Yoda, K., Kawada, T., Kaibara, C., Fujie, A., Abe, M., Hitoshi, n.u.l.l., Hashimoto, n.u.l.l., Shimizu, J., Tomishige, N., Noda, Y., Yamasaki, M. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  3. Cloning and characterization of a gene which determines osmotic stability in Saccharomyces cerevisiae. Stateva, L.I., Oliver, S.G., Trueman, L.J., Venkov, P.V. Mol. Cell. Biol. (1991) [Pubmed]
  4. Glycosylation deficiency phenotypes resulting from depletion of GDP-mannose pyrophosphorylase in two yeast species. Warit, S., Zhang, N., Short, A., Walmsley, R.M., Oliver, S.G., Stateva, L.I. Mol. Microbiol. (2000) [Pubmed]
  5. The VIG9 gene products from the human pathogenic fungi Candida albicans and Candida glabrata encode GDP-mannose pyrophosphorylase. Ohta, A., Chibana, H., Arisawa, M., Sudoh, M. Biochim. Biophys. Acta (2000) [Pubmed]
  6. Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast. Cullen, P.J., Schultz, J., Horecka, J., Stevenson, B.J., Jigami, Y., Sprague, G.F. Genetics (2000) [Pubmed]
  7. Isolation of a Trichoderma reesei cDNA encoding GTP: a-D-mannose-1-phosphate guanyltransferase involved in early steps of protein glycosylation. Kruszewska, J.S., Saloheimo, M., Penttilä, M., Palamarczyk, G. Curr. Genet. (1998) [Pubmed]
  8. Down-regulation of the expression of PKC1 and SRB1/PSA1/VIG9, two genes involved in cell wall integrity in Saccharomyces cerevisiae, causes flocculation. Zhang, N., Gardner, D.C., Oliver, S.G., Stateva, L.I. Microbiology (Reading, Engl.) (1999) [Pubmed]
  9. Over-expression of S. cerevisiae G1 cyclins restores the viability of alg1 N-glycosylation mutants. Benton, B.K., Plump, S.D., Roos, J., Lennarz, W.J., Cross, F.R. Curr. Genet. (1996) [Pubmed]
  10. Suppression of sorbitol dependence in a strain bearing a mutation in the SRB1/PSA1/VIG9 gene encoding GDP-mannose pyrophosphorylase by PDE2 overexpression suggests a role for the Ras/cAMP signal-transduction pathway in the control of yeast cell-wall biogenesis. Tomlin, G.C., Hamilton, G.E., Gardner, D.C., Walmsley, R.M., Stateva, L.I., Oliver, S.G. Microbiology (Reading, Engl.) (2000) [Pubmed]
  11. Decreased synthesis of alkali-soluble glucan in a cell-wall mutant of Saccharomyces cerevisiae. Blagoeva, J., Venkov, P. Biochem. Int. (1990) [Pubmed]
  12. L-ascorbic acid biosynthesis. Smirnoff, N. Vitam. Horm. (2001) [Pubmed]
  13. Overexpression of GDP-mannose pyrophosphorylase in Saccharomyces cerevisiae corrects defects in dolichol-linked saccharide formation and protein glycosylation. Janik, A., Sosnowska, M., Kruszewska, J., Krotkiewski, H., Lehle, L., Palamarczyk, G. Biochim. Biophys. Acta (2003) [Pubmed]
  14. Complementation of the Saccharomyces cerevisiae srb1-1 mutation: an autoselection system for stable plasmid maintenance. Rech, S.B., Stateva, L.I., Oliver, S.G. Curr. Genet. (1992) [Pubmed]
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