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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Drug Hypersensitivity

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Disease relevance of Drug Hypersensitivity


High impact information on Drug Hypersensitivity


Chemical compound and disease context of Drug Hypersensitivity


Biological context of Drug Hypersensitivity

  • In 77 enrolled patients, including those with previous iron dextran sensitivity, other drug allergies, or concurrent angiotensin-converting enzyme inhibitor use, we saw no serious adverse drug reactions and no change in intradialytic blood pressure associated with iron sucrose administration [16].

Anatomical context of Drug Hypersensitivity


Gene context of Drug Hypersensitivity


Analytical, diagnostic and therapeutic context of Drug Hypersensitivity


  1. Marked atypical lymphocytosis, hepatitis, and skin rash in sulfasalazine drug allergy. Poland, G.A., Love, K.R. Am. J. Med. (1986) [Pubmed]
  2. Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus. Coen, D.M., Fleming, H.E., Leslie, L.K., Retondo, M.J. J. Virol. (1985) [Pubmed]
  3. Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection. Chapman, T.M., Plosker, G.L., Perry, C.M. Drugs (2004) [Pubmed]
  4. The accuracy of the diagnosis of suspected paracetamol (acetaminophen) hypersensitivity: results of a single-blinded trial. Kvedariene, V., Bencherioua, A.M., Messaad, D., Godard, P., Bousquet, J., Demoly, P. Clin. Exp. Allergy (2002) [Pubmed]
  5. Angioedema associated with droperidol administration. Palombaro, J.F., Klingelberger, C.E. Annals of emergency medicine. (1996) [Pubmed]
  6. Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Martin, A.M., Nolan, D., Gaudieri, S., Almeida, C.A., Nolan, R., James, I., Carvalho, F., Phillips, E., Christiansen, F.T., Purcell, A.W., McCluskey, J., Mallal, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals. Brander, C., Mauri-Hellweg, D., Bettens, F., Rolli, H., Goldman, M., Pichler, W.J. J. Immunol. (1995) [Pubmed]
  8. Allergy in systemic lupus erythematosus. IgE levels and reaginic phenomenon. Goldman, J.A., Klimek, G.A., Ali, R. Arthritis Rheum. (1976) [Pubmed]
  9. Transient monoclonal proteins in drug hypersensitivity reactions. del Carpio, J., Espinoza, L.R., Lauter, S., Osterland, C.K. Am. J. Med. (1979) [Pubmed]
  10. Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity. Depta, J.P., Altznauer, F., Gamerdinger, K., Burkhart, C., Weltzien, H.U., Pichler, W.J. J. Allergy Clin. Immunol. (2004) [Pubmed]
  11. Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins. Meekins, C.V., Sullivan, T.J., Gruchalla, R.S. J. Allergy Clin. Immunol. (1994) [Pubmed]
  12. Atopy and anaphylactic reactions to suxamethonium. Charpin, D., Benzarti, M., Hémon, Y., Senft, M., Alazia, M., Arnaud, A., Vervloet, D., Charpin, J. J. Allergy Clin. Immunol. (1988) [Pubmed]
  13. Allergy to tartrazine in psychotropic drugs. Bhatia, M.S. The Journal of clinical psychiatry. (2000) [Pubmed]
  14. P450 2C18 catalyzes the metabolic bioactivation of phenytoin. Kinobe, R.T., Parkinson, O.T., Mitchell, D.J., Gillam, E.M. Chem. Res. Toxicol. (2005) [Pubmed]
  15. Synthesis and characterization of protein and polylysine conjugates of sulfamethoxazole and sulfanilic acid for investigation of sulfonamide drug allergy. Tatake, J.G., Knapp, M.M., Ressler, C. Bioconjug. Chem. (1991) [Pubmed]
  16. Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial. Charytan, C., Levin, N., Al-Saloum, M., Hafeez, T., Gagnon, S., Van Wyck, D.B. Am. J. Kidney Dis. (2001) [Pubmed]
  17. Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions. Davoine, F., Lavigne, S., Chakir, J., Ferland, C., Boulay, M.E., Laviolette, M. J. Allergy Clin. Immunol. (2002) [Pubmed]
  18. Prealbumin bearing lymphocytes as an indicator of hapten protein carrier in certain varieties of dermatitis. Husz, S., Hamerlinck, F., Cormane, R.H. Br. J. Dermatol. (1975) [Pubmed]
  19. Predictive capacity of histamine release for the diagnosis of drug allergy. Demoly, P., Lebel, B., Messaad, D., Sahla, H., Rongier, M., Daurès, J.P., Godard, P., Bousquet, J. Allergy (1999) [Pubmed]
  20. Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters. Del Sorbo, G., Andrade, A.C., Van Nistelrooy, J.G., Van Kan, J.A., Balzi, E., De Waard, M.A. Mol. Gen. Genet. (1997) [Pubmed]
  21. Distinct serum cytokine levels in drug- and measles-induced exanthema. Hari, Y., Urwyler, A., Hurni, M., Yawalkar, N., Dahinden, C., Wendland, T., Braathen, L.R., Matter, L., Pichler, W.J. Int. Arch. Allergy Immunol. (1999) [Pubmed]
  22. Effective acute desensitization for immediate-type hypersensitivity to human granulocyte-monocyte colony stimulating factor. Shahar, E., Krivoy, N., Pollack, S. Ann. Allergy Asthma Immunol. (1999) [Pubmed]
  23. Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype. Poot, M., Gollahon, K.A., Emond, M.J., Silber, J.R., Rabinovitch, P.S. FASEB J. (2002) [Pubmed]
  24. Assessment of preferential cleavage of an actively transcribed retroviral hybrid gene in murine cells by deoxyribonuclease I, bleomycin, neocarzinostatin, or ionizing radiation. Beckmann, R.P., Agostino, M.J., McHugh, M.M., Sigmund, R.D., Beerman, T.A. Biochemistry (1987) [Pubmed]
  25. Interstitial nephritis caused by methicillin. Studies in a case complicating staphylococcal sepsis with acute glomerulonephritis. Silverstein, R.L., Eigenbrodt, E.H., McPhaul, J.J. Am. J. Clin. Pathol. (1981) [Pubmed]
  26. Diagnosis and pathogenesis of the anaphylactic and anaphylactoid reactions to anaesthetics. Gueant, J.L., Aimone-Gastin, I., Namour, F., Laroche, D., Bellou, A., Laxenaire, M.C. Clin. Exp. Allergy (1998) [Pubmed]
  27. Adverse reactions to OsteoSet bone graft substitute, the incidence in a consecutive series. Lee, G.H., Khoury, J.G., Bell, J.E., Buckwalter, J.A. The Iowa orthopaedic journal. (2002) [Pubmed]
  28. Bronchoalveolar lavage in acute drug-hypersensitivity pneumonitis probably caused by phenytoin. Munn, N.J., Baughman, R.P., Ploysongsang, Y., Wirman, J.A., Bullock, W.E. South. Med. J. (1984) [Pubmed]
  29. Drug induced acute generalized exanthematous pustulosis. Katagiri, K., Takayasu, S. J. Dermatol. (1996) [Pubmed]
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