Gene Review:
ATCAY - ataxia, cerebellar, Cayman type
Homo sapiens
Synonyms:
Ataxia cayman type protein, BNIP-2-homology, BNIP-H, CLAC, Caytaxin, ...
- Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. Kowa, H., Sakakura, T., Matsuura, Y., Wakabayashi, T., Mann, D.M., Duff, K., Tsuji, S., Hashimoto, T., Iwatsubo, T. Am. J. Pathol. (2004)
- Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. Buschdorf, J.P., Li Chew, L., Zhang, B., Cao, Q., Liang, F.Y., Liou, Y.C., Zhou, Y.T., Low, B.C. J. Cell. Sci. (2006)
- CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. Osada, Y., Hashimoto, T., Nishimura, A., Matsuo, Y., Wakabayashi, T., Iwatsubo, T. J. Biol. Chem. (2005)
- Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. Bomar, J.M., Benke, P.J., Slattery, E.L., Puttagunta, R., Taylor, L.P., Seong, E., Nystuen, A., Chen, W., Albin, R.L., Patel, P.D., Kittles, R.A., Sheffield, V.C., Burmeister, M. Nat. Genet. (2003)
- CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. Hashimoto, T., Wakabayashi, T., Watanabe, A., Kowa, H., Hosoda, R., Nakamura, A., Kanazawa, I., Arai, T., Takio, K., Mann, D.M., Iwatsubo, T. EMBO J. (2002)
- Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site. Söderberg, L., Kakuyama, H., Möller, A., Ito, A., Winblad, B., Tjernberg, L.O., Näslund, J. J. Biol. Chem. (2005)
- Caytaxin deficiency disrupts signaling pathways in cerebellar cortex. Xiao, J., Gong, S., Ledoux, M.S. Neuroscience (2007)
- Expression and localization of Cayman ataxia-related protein, Caytaxin, is regulated in a developmental- and spatial-dependent manner. Hayakawa, Y., Itoh, M., Yamada, A., Mitsuda, T., Nakagawa, T. Brain Res. (2007)
- Efficiency of beta-adrenoceptor subtype coupling to cardiac adenylyl cyclase in cardiomyopathic and control hamsters. Witte, K., Schnecko, A., Olbrich, H.G., Lemmer, B. Eur. J. Pharmacol. (1995)
- Caytaxin deficiency causes generalized dystonia in rats. Xiao, J., Ledoux, M.S. Brain Res. Mol. Brain Res. (2005)
- Enantioselective affinity chromatography of a chiral drug by crystalline and carrier-bound antibody fab fragment. Vuolanto, A., Leisola, M., Jokela, J. Biotechnol. Prog. (2004)
- Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates. Söderberg, L., Dahlqvist, C., Kakuyama, H., Thyberg, J., Ito, A., Winblad, B., Näslund, J., Tjernberg, L.O. FEBS J. (2005)
- CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation. Kakuyama, H., Söderberg, L., Horigome, K., Winblad, B., Dahlqvist, C., Näslund, J., Tjernberg, L.O. Biochemistry (2005)