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Disease relevance of Neurophysiology

  • This historical vignette represents recognition of the legacy of those many creative pioneers in this field of study, primarily in the areas of development of functional and stereotactic methods, epilepsy surgery, human neurophysiology, pain, movement disorders, neuroendocrine surgery, and psychiatric illnesses [1].
  • West Nile virus neuropathy and other topics: the best of the IFCN/AAEM. Highlights of the Joint Meeting of the International Federation of Clinical Neurophysiology and the American Association of Electrodiagnostic Medicine, San Francisco, CA, September 16-20, 2003 [2].

Psychiatry related information on Neurophysiology


High impact information on Neurophysiology


Biological context of Neurophysiology


Anatomical context of Neurophysiology


Associations of Neurophysiology with chemical compounds

  • Jon Kaas received a Ph.D. in Psychology with Irving Diamond at Duke University and completed a postdoctoral fellowship with Clinton Woolsey in neurophysiology at the University of Wisconsin, where he also collaborated with Ray Guillery [19].
  • The existence and possible functional relevance of bradykinin and kallidin (the peptides), kallikreins (the proteolytic enzymes), and kininases (the peptidases) in neurophysiology and neuropathological states are discussed in this review [20].
  • Chemical-induced changes in the structure or persistent changes in behavior, neurochemistry, or neurophysiology of the nervous system are regarded as neurotoxic effects [21].
  • RESULTS: Infants with PD mothers did not show more high reactivity, behavioral inhibition, or ambivalent/resistant attachment but did demonstrate different neurophysiology (higher salivary cortisol and more disturbed sleep) than controls [22].
  • In the present paper, recent data on cerebro cerebellar interactions is reviewed, particularly focusing on cerebellar influences over the neurophysiology of primary motor and primary sensory cortices [23].

Gene context of Neurophysiology

  • As a model system to study the potential role of CPE in neurophysiology, we carried out electroretinography (ERG) and retinal morphological studies on Cpe-/- and Cpe fat/fat mutant mice [24].
  • Recently, knockout mice deficient in the CB1 cannabinoid receptor have been generated, and these animals result in an excellent tool to evaluate the neurophysiology of the endogenous cannabinoid system [25].
  • Much of the data on the involvement of plasminogen activators in neurophysiology and -pathology have been derived from studies on experimental animals [26].
  • 3. Knowledge of the heterogeneous distribution of the central endothelin receptor subtypes aids in understanding the neurophysiology of endothelins [27].
  • All subjects underwent a dedicated MRI study of the brainstem and the whole series of brainstem tests currently used in clinical neurophysiology: early (R1) and late (R2) blink reflex, early (SP1) and late (SP2) masseter inhibitory reflex, and the jaw jerk to chin tapping [28].

Analytical, diagnostic and therapeutic context of Neurophysiology


  1. Reflections on a stereotactic and functional journey: the blessing and inspiration of working among giants. Marino, R. Neurosurgery (2005) [Pubmed]
  2. West Nile virus neuropathy and other topics: the best of the IFCN/AAEM. Highlights of the Joint Meeting of the International Federation of Clinical Neurophysiology and the American Association of Electrodiagnostic Medicine, San Francisco, CA, September 16-20, 2003. Kelly, J.J. Reviews in neurological diseases. (2004) [Pubmed]
  3. The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization. Hening, W. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2004) [Pubmed]
  4. Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein. Whittington, M.A., Sidle, K.C., Gowland, I., Meads, J., Hill, A.F., Palmer, M.S., Jefferys, J.G., Collinge, J. Nat. Genet. (1995) [Pubmed]
  5. Neurophysiology of epilepsy. Prince, D.A. Annu. Rev. Neurosci. (1978) [Pubmed]
  6. Prions and the immune system: a journey through gut, spleen, and nerves. Aguzzi, A. Adv. Immunol. (2003) [Pubmed]
  7. Cocaine addiction: psychology and neurophysiology. Gawin, F.H. Science (1991) [Pubmed]
  8. The computation of directional selectivity in the retina occurs presynaptic to the ganglion cell. Borg-Graham, L.J. Nat. Neurosci. (2001) [Pubmed]
  9. Interview with Apostolos P. Georgopoulos. Georgopoulos, A.P. Journal of cognitive neuroscience. (1998) [Pubmed]
  10. Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. Yocca, F.D. Journal of clinical psychopharmacology. (1990) [Pubmed]
  11. Newer antiepileptic drugs. Towards an improved risk-benefit ratio. Patsalos, P.N., Sander, J.W. Drug safety : an international journal of medical toxicology and drug experience. (1994) [Pubmed]
  12. Shaping multisensory action-space with tools: evidence from patients with cross-modal extinction. Farnè, A., Iriki, A., Làdavas, E. Neuropsychologia. (2005) [Pubmed]
  13. Susceptibility to demyelinating polyneuropathy in plasma cell dyscrasia may be influenced by amino acid position 9 of the HLA-DR beta chain. Vrethem, M., Ernerudh, J., Cruz, M., Olerup, O., Solders, G., Ekstedt, B., Andersen, O., Hillert, J. J. Neuroimmunol. (1993) [Pubmed]
  14. L-glutamate excitation of A10 dopamine neurons is preferentially mediated by activation of NMDA receptors: extra- and intracellular electrophysiological studies in brain slices. Wang, T., French, E.D. Brain Res. (1993) [Pubmed]
  15. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Waldinger, M.D., Berendsen, H.H., Blok, B.F., Olivier, B., Holstege, G. Behav. Brain Res. (1998) [Pubmed]
  16. Welander distal myopathy--an overview. Borg, K., Ahlberg, G., Anvret, M., Edström, L. Neuromuscul. Disord. (1998) [Pubmed]
  17. Caytaxin deficiency causes generalized dystonia in rats. Xiao, J., Ledoux, M.S. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  18. Physiology and glomerular projections of olfactory receptor neurons on the antenna of female Heliothis virescens (Lepidoptera: Noctuidae) responsive to behaviorally relevant odors. Hillier, N.K., Kleineidam, C., Vickers, N.J. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. (2006) [Pubmed]
  19. Interview with John Kaas. Kaas, J. Journal of cognitive neuroscience. (1999) [Pubmed]
  20. Pathophysiology of the kallikrein-kinin system in mammalian nervous tissue. Raidoo, D.M., Bhoola, K.D. Pharmacol. Ther. (1998) [Pubmed]
  21. Evolution and current status of neurotoxicity risk assessment. Tilson, H.A. Drug Metab. Rev. (1996) [Pubmed]
  22. Maternal panic disorder: infant temperament, neurophysiology, and parenting behaviors. Warren, S.L., Gunnar, M.R., Kagan, J., Anders, T.F., Simmens, S.J., Rones, M., Wease, S., Aron, E., Dahl, R.E., Sroufe, L.A. Journal of the American Academy of Child and Adolescent Psychiatry. (2003) [Pubmed]
  23. Neuronal plasticity of interrelated cerebellar and cortical networks. Molinari, M., Filippini, V., Leggio, M.G. Neuroscience (2002) [Pubmed]
  24. Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina. Zhu, X., Wu, K., Rife, L., Cawley, N.X., Brown, B., Adams, T., Teofilo, K., Lillo, C., Williams, D.S., Loh, Y.P., Craft, C.M. J. Neurochem. (2005) [Pubmed]
  25. Involvement of CB1 cannabinoid receptors in emotional behaviour. Martin, M., Ledent, C., Parmentier, M., Maldonado, R., Valverde, O. Psychopharmacology (Berl.) (2002) [Pubmed]
  26. Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Teesalu, T., Kulla, A., Simisker, A., Sirén, V., Lawrence, D.A., Asser, T., Vaheri, A. Thromb. Haemost. (2004) [Pubmed]
  27. The endothelin ETA receptor exists in the caudal solitary tract nucleus of the rat brain. Shibata, S., Niwa, M., Himeno, A., Gana, N.G., Shigematsu, K., Matsumoto, M., Yamashita, K., Sumikawa, K., Taniyama, K. Cell. Mol. Neurobiol. (1997) [Pubmed]
  28. Brainstem reflex circuits revisited. Cruccu, G., Iannetti, G.D., Marx, J.J., Thoemke, F., Truini, A., Fitzek, S., Galeotti, F., Urban, P.P., Romaniello, A., Stoeter, P., Manfredi, M., Hopf, H.C. Brain (2005) [Pubmed]
  29. Clinical neurophysiology referral patterns to a tertiary hospital--a prospective audit. Renganathan, R., O'Brien, S., Sweeney, B., Galvin, R., McNamara, B. Irish journal of medical science. (2004) [Pubmed]
  30. Imaging the Dopamine System with In Vivo [11C]raclopride Displacement Studies: Understanding the True Mechanism. Ginovart, N. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. (2005) [Pubmed]
  31. The neurophysiology of the alternating leg muscle activation (ALMA) during sleep: study of one patient before and after treatment with pramipexole. Cosentino, F.I., Iero, I., Lanuzza, B., Tripodi, M., Ferri, R. Sleep Med. (2006) [Pubmed]
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