The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

RPP2A  -  ribosomal protein P2A

Saccharomyces cerevisiae S288c

Synonyms: 60S acidic ribosomal protein P2-alpha, A2, L12EIB, L44, P2A, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RPP2A


High impact information on RPP2A

  • By gene disruption techniques with linearized DNA from these constructions, strains of Saccharomyces cerevisiae were obtained which lacked a functional gene for either protein L44 or protein L45 [2].
  • These data suggest that TOG mediates the association of hnRNP A2-positive granules with microtubules during transport and/or localization [3].
  • In neural cells, such as oligodendrocytes and neurons, transport of certain RNAs along microtubules is mediated by the cis-acting heterogeneous nuclear ribonucleoprotein A2 response element (A2RE) trafficking element and the cognate trans-acting heterogeneous nuclear ribonucleoprotein (hnRNP) A2 trafficking factor [3].
  • TOG coimmunoprecipitates with hnRNP A2 present in the cytoskeleton (CSK) fraction of neural cells, and both coprecipitate with microtubule stabilized pellets [3].
  • Sequencing of tryptic phosphopeptides has shown that acidic proteins YP1 alpha and YP2 alpha (L44) are also phosphorylated at positions near the carboxyl end [4].

Biological context of RPP2A


Anatomical context of RPP2A

  • The RPL44' gene from Saccharomyces cerevisiae encoding the ribosomal protein YP1 beta(L44') has been found to be linked to the STF1 gene, encoding a stabilizing factor of the F1F0-ATPase inhibitor protein from mitochondria [7].

Associations of RPP2A with chemical compounds

  • Two-dimensional polyacrylamide-gel electrophoretic analysis of yeast ribosomal proteins labelled in vivo with 32PO43- revealed that the proteins S2 and S10 of the 40S ribosomal subunit, and the proteins L9, L30, L44 and L45 of the 60S ribosomal subunit, are phosphorylated in vivo [8].
  • Core particles derived from yeast ribosomes by treatment with 50% ethanol and 0.4 M NH4Cl (P0.4 cores) are derived of the acidic proteins L44/45 functionally equivalent to the bacterial proteins L7 and L12 [9].
  • Furthermore, the secretion of alpha-amylase activity is drastically repressed by glucose in both Sw. occidentalis and a transformant of S. cerevisiae containing SW A2 [10].
  • Wild-type and mutant receptors were expressed in yeast cells and assayed for their ability to transactivate an estrogen-responsive reporter plasmid (ERE-CYCl-LacZ) that contained a single estrogen response element of the vitellogenin A2 gene promoter [11].
  • Upon genetically deleting the glycosylation site, the level of secretion decreased to 3.6 mg prophospholipase A2 per 1 [12].

Physical interactions of RPP2A

  • We previously identified an alternatively spliced variant of the chicken A subunit in which a 30 amino acid cassette (A1) containing the Walker consensus sequence for ATP binding is replaced by a 24 amino acid cassette (A2) that lacks this feature [13].

Other interactions of RPP2A

  • Purified ribosomal proteins together with specific rabbit antisera were used to identify the two smaller rRNP antigens as the acidic phosphoproteins of the large ribosomal subunit, designated P1/P2(L40/L41) (rat), eL7/eL12 (Artemia, brine shrimp), and A1/A2 (yeast) [14].

Analytical, diagnostic and therapeutic context of RPP2A


  1. Cell cycle function of a Medicago sativa A2-type cyclin interacting with a PSTAIRE-type cyclin-dependent kinase and a retinoblastoma protein. Roudier, F., Fedorova, E., Györgyey, J., Feher, A., Brown, S., Kondorosi, A., Kondorosi, E. Plant J. (2000) [Pubmed]
  2. Disruption of single-copy genes encoding acidic ribosomal proteins in Saccharomyces cerevisiae. Remacha, M., Santos, C., Ballesta, J.P. Mol. Cell. Biol. (1990) [Pubmed]
  3. The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. Kosturko, L.D., Maggipinto, M.J., D'Sa, C., Carson, J.H., Barbarese, E. Mol. Biol. Cell (2005) [Pubmed]
  4. The activity-controlling phosphorylation site is not the same in the four acidic ribosomal proteins from Saccharomyces cerevisiae. Naranda, T., Remacha, M., Ballesta, J.P. J. Biol. Chem. (1993) [Pubmed]
  5. Chromosome location of a family of genes encoding different acidic ribosomal proteins in Saccharomyces cerevisiae. Remacha, M., Ramirez, L., Marin, I., Ballesta, J.P. Curr. Genet. (1990) [Pubmed]
  6. Independent genes coding for three acidic proteins of the large ribosomal subunit from Saccharomyces cerevisiae. Remacha, M., Sáenz-Robles, M.T., Vilella, M.D., Ballesta, J.P. J. Biol. Chem. (1988) [Pubmed]
  7. RPL44 and RPL44', encoding acidic ribosomal phosphoproteins YP2 alpha(L44) and YP1 beta(L44'), are adjacent to rig and STF1 on Saccharomyces cerevisiae chromosomes XV and IV respectively. Rodriguez-Gabriel, M.A., Zambrano, R., Ballesta, J.P. Yeast (1994) [Pubmed]
  8. Modification of yeast ribosomal proteins. Phosphorylation. Kruiswijk, T., de Hey, J.T., Planta, R.J. Biochem. J. (1978) [Pubmed]
  9. Functional role of acidic ribosomal proteins. Interchangeability of proteins from bacterial and eukaryotic cells. Sánchez-Madrid, F., Vidales, F.J., Ballesta, J.P. Biochemistry (1981) [Pubmed]
  10. Isolation of a new gene (SW A2) encoding an alpha-amylase from Schwanniomyces occidentalis and its expression in Saccharomyces cerevisiae. Abarca, D., Fernández-Lobato, M., del Pozo, L., Jiménez, A. FEBS Lett. (1991) [Pubmed]
  11. Two transcription activation functions in the amino terminus of the mouse estrogen receptor that are affected by the carboxy terminus. Gandini, O., Kohno, H., Curtis, S., Korach, K.S. Steroids (1997) [Pubmed]
  12. The use of genetic engineering to obtain efficient production of porcine pancreatic phospholipase A2 by Saccharomyces cerevisiae. Bekkers, A.C., Franken, P.A., Van den Bergh, C.J., Verbakel, J.M., Verheij, H.M., De Haas, G.H. Biochim. Biophys. Acta (1991) [Pubmed]
  13. The presence of the alternatively spliced A2 cassette in the vacuolar H+-ATPase subunit A prevents assembly of the V1 catalytic domain. Hernando, N., David, P., Tarsio, M., Bartkiewicz, M., Horne, W.C., Kane, P.M., Baron, R. Eur. J. Biochem. (1999) [Pubmed]
  14. Identification of ribosomal protein autoantigens. Francoeur, A.M., Peebles, C.L., Heckman, K.J., Lee, J.C., Tan, E.M. J. Immunol. (1985) [Pubmed]
WikiGenes - Universities