Gene Review:
PTCH2 - patched 2
Homo sapiens
Synonyms:
PTC2, Protein patched homolog 2, UNQ560/PRO1121/PRO57079
- Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32. Smyth, I., Narang, M.A., Evans, T., Heimann, C., Nakamura, Y., Chenevix-Trench, G., Pietsch, T., Wicking, C., Wainwright, B.J. Hum. Mol. Genet. (1999)
- PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. Zaphiropoulos, P.G., Undén, A.B., Rahnama, F., Hollingsworth, R.E., Toftgård, R. Cancer Res. (1999)
- Carcinogenesis of basal cell carcinomas: genetics and molecular mechanisms. Lacour, J.P. Br. J. Dermatol. (2002)
- A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis type 1. Endo, H., Utani, A., Matsumoto, F., Kuroki, T., Yoshimoto, S., Ichinose, M., Shinkai, H. Br. J. Dermatol. (2003)
- Expression and function of sonic hedgehog pathway components in pituitary adenomas: evidence for a direct role in hormone secretion and cell proliferation. Vila, G., Theodoropoulou, M., Stalla, J., Tonn, J.C., Losa, M., Renner, U., Stalla, G.K., Paez-Pereda, M. J. Clin. Endocrinol. Metab. (2005)
- Loss of function effect of RET mutations causing Hirschsprung disease. Pasini, B., Borrello, M.G., Greco, A., Bongarzone, I., Luo, Y., Mondellini, P., Alberti, L., Miranda, C., Arighi, E., Bocciardi, R. Nat. Genet. (1995)
- Characterization of two patched receptors for the vertebrate hedgehog protein family. Carpenter, D., Stone, D.M., Brush, J., Ryan, A., Armanini, M., Frantz, G., Rosenthal, A., de Sauvage, F.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Pearse, R.V., Vogan, K.J., Tabin, C.J. Dev. Biol. (2001)
- Isoform-specific phosphorylation of fission yeast type 2C protein phosphatase. Kobayashi, T., Sadaie, M., Ohnishi, M., Wang, H., Ikeda, S., Hanada, M., Yanagawa, Y., Nakajima, T., Tamura, S. Biochem. Biophys. Res. Commun. (1998)
- Familial adenomatous polyposis-associated thyroid cancer: a clinical, pathological, and molecular genetics study. Soravia, C., Sugg, S.L., Berk, T., Mitri, A., Cheng, H., Gallinger, S., Cohen, Z., Asa, S.L., Bapat, B.V. Am. J. Pathol. (1999)
- Low prevalence of RET rearrangements (RET/PTC1, RET/PTC2, RET/PTC3, and ELKS-RET) in sporadic papillary thyroid carcinomas in Taiwan Chinese. Liu, R.T., Chou, F.F., Wang, C.H., Lin, C.L., Chao, F.P., Chung, J.C., Huang, C.C., Wang, P.W., Cheng, J.T. Thyroid (2005)
- ret/PTC-1, -2, and -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential? Sugg, S.L., Zheng, L., Rosen, I.B., Freeman, J.L., Ezzat, S., Asa, S.L. J. Clin. Endocrinol. Metab. (1996)
- Distinct roles of PTCH2 splice variants in Hedgehog signalling. Rahnama, F., Toftgård, R., Zaphiropoulos, P.G. Biochem. J. (2004)