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Gene Review

Dhh  -  desert hedgehog

Mus musculus

Synonyms: C78960, DHH, Desert hedgehog protein, HHG-3
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Disease relevance of Dhh


High impact information on Dhh


Biological context of Dhh

  • Rat Dhh complete coding sequence (CDS) was determined by assembling nucleotide positions 426397-426963, 429715-429976 and 430244-430898 of the AC114446.3 genome sequence [7].
  • Here, we identified and characterized rat Dhh and Ihh genes by using bioinformatics [7].
  • Thus the elucidation of Shh (and Dhh) target gene activation in the skin will likely identify those genes responsible for increasing the proliferative potential of epidermal basal cells and the mechanisms involved in regulating epidermal stem cell fate [2].
  • Analysis of a null mutant demonstrates that Dhh signaling plays an essential role in the regulation of mammalian spermatogenesis [8].
  • However, nothing is known of the roles of Dhh or Ihh, nor of the possible function of Shh during later embryogenesis [9].

Anatomical context of Dhh


Associations of Dhh with chemical compounds

  • These behavioral abnormalities of Dhh KO male mice may be due to lower testosterone levels with abnormal development of the testes caused by Dhh-null mutation [12].

Other interactions of Dhh

  • These findings suggest that a mechanism for fine-tuning the biological actions of Shh, Ihh, and Dhh, exists beyond the simple temporal and spatial control of their expression domains within the developing and adult organism [10].
  • These phenotypes associated also with the decreased expression of Sox9, Desert hedgehog, Hsd3beta, Platelet/endothelial cell adhesion molecule, and alpha-smooth muscle actin, which are markers of the Sertoli, Leydig, endothelial, and peritubular myoid cells of the developing testis [13].
  • The expression of Patched is lost in Dhh mutants [8].
  • Dhh expression is initiated in Sertoli cell precursors shortly after the activation of Sry and persists in the testis into the adult [8].
  • These results suggest that the Dhh-Ptc2 signaling pathway may be involved in the maintenance of adult nerves and may be one of the factors that directly or indirectly determines the response of peripheral nerves to injury [4].

Analytical, diagnostic and therapeutic context of Dhh


  1. Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Fukaya, M., Isohata, N., Ohta, H., Aoyagi, K., Ochiya, T., Saeki, N., Yanagihara, K., Nakanishi, Y., Taniguchi, H., Sakamoto, H., Shimoda, T., Nimura, Y., Yoshida, T., Sasaki, H. Gastroenterology (2006) [Pubmed]
  2. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Adolphe, C., Narang, M., Ellis, T., Wicking, C., Kaur, P., Wainwright, B. Development (2004) [Pubmed]
  3. Expression of hedgehog signalling components in adult mouse testis. Szczepny, A., Hime, G.R., Loveland, K.L. Dev. Dyn. (2006) [Pubmed]
  4. Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. Bajestan, S.N., Umehara, F., Shirahama, Y., Itoh, K., Sharghi-Namini, S., Jessen, K.R., Mirsky, R., Osame, M. J. Neurobiol. (2006) [Pubmed]
  5. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Yao, H.H., Whoriskey, W., Capel, B. Genes Dev. (2002) [Pubmed]
  6. Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Parmantier, E., Lynn, B., Lawson, D., Turmaine, M., Namini, S.S., Chakrabarti, L., McMahon, A.P., Jessen, K.R., Mirsky, R. Neuron (1999) [Pubmed]
  7. Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. Katoh, Y., Katoh, M. Int. J. Oncol. (2005) [Pubmed]
  8. Sertoli cell signaling by Desert hedgehog regulates the male germline. Bitgood, M.J., Shen, L., McMahon, A.P. Curr. Biol. (1996) [Pubmed]
  9. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Bitgood, M.J., McMahon, A.P. Dev. Biol. (1995) [Pubmed]
  10. Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Pathi, S., Pagan-Westphal, S., Baker, D.P., Garber, E.A., Rayhorn, P., Bumcrot, D., Tabin, C.J., Blake Pepinsky, R., Williams, K.P. Mech. Dev. (2001) [Pubmed]
  11. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. Clark, A.M., Garland, K.K., Russell, L.D. Biol. Reprod. (2000) [Pubmed]
  12. Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice. Umehara, F., Mishima, K., Egashira, N., Ogata, A., Iwasaki, K., Fujiwara, M. Behav. Brain Res. (2006) [Pubmed]
  13. Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Chi, L., Itäranta, P., Zhang, S., Vainio, S. Endocrinology (2006) [Pubmed]
  14. Schwann cell-derived desert hedgehog signals nerve sheath formation. Mirsky, R., Parmantier, E., McMahon, A.P., Jessen, K.R. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
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