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Gene Review

aroE  -  shikimate 5-dehydrogenase

Escherichia coli O157:H7 str. Sakai

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Disease relevance of aroE


High impact information on aroE


Chemical compound and disease context of aroE


Biological context of aroE


Anatomical context of aroE

  • One of the mutants (cbt) was apparently defective in outer membrane ferri-enterochelin receptor activity. aroE derivatives (unable to synthesize enterochelin) of the four mutant classes and the parent strain produced increased amounts of two outer membranes polypeptides when grown under iron stress [11].

Associations of aroE with chemical compounds


Analytical, diagnostic and therapeutic context of aroE


  1. The sequence of the distal end of the E. coli ribosomal RNA rrnE operon indicates conserved features are shared by rrn operons. Liebke, H., Hatfull, G. Nucleic Acids Res. (1985) [Pubmed]
  2. Imidazole acetol phosphate aminotransferase in Zymomonas mobilis: molecular genetic, biochemical, and evolutionary analyses. Gu, W., Zhao, G., Eddy, C., Jensen, R.A. J. Bacteriol. (1995) [Pubmed]
  3. Pigment and virulence deficiencies associated with mutations in the aroE gene of Xanthomonas oryzae pv. oryzae. Goel, A.K., Rajagopal, L., Sonti, R.V. Appl. Environ. Microbiol. (2001) [Pubmed]
  4. Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori. Han, C., Wang, L., Yu, K., Chen, L., Hu, L., Chen, K., Jiang, H., Shen, X. FEBS J. (2006) [Pubmed]
  5. Cloning of cDNA encoding the bifunctional dehydroquinase.shikimate dehydrogenase of aromatic-amino-acid biosynthesis in Nicotiana tabacum. Bonner, C.A., Jensen, R.A. Biochem. J. (1994) [Pubmed]
  6. Conditionally lethal ribosomal protein mutants: characterization of a locus required for modification of 50S subunit proteins. Kushner, S.R., Maples, V.F., Champney, W.S. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  7. Site-directed mutagenesis of the active site region in the quinate/shikimate 5-dehydrogenase YdiB of Escherichia coli. Lindner, H.A., Nadeau, G., Matte, A., Michel, G., Ménard, R., Cygler, M. J. Biol. Chem. (2005) [Pubmed]
  8. Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities. Michel, G., Roszak, A.W., Sauvé, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M., Lapthorn, A.J. J. Biol. Chem. (2003) [Pubmed]
  9. Localized mutagenesis of the aroE-strA section of the Escherichia coli chromosome coding for ribosomal proteins. Berger, I., Geyl, D., Böck, A., Stöffler, G., Wittmann, H.G. Mol. Gen. Genet. (1975) [Pubmed]
  10. Crystallization and preliminary X-ray analysis of shikimate dehydrogenase from Escherichia coli. Maclean, J., Campbell, S.A., Pollock, K., Chackrewarthy, S., Coggins, J.R., Lapthorn, A.J. Acta Crystallogr. D Biol. Crystallogr. (2000) [Pubmed]
  11. Iron uptake in colicin B-resistant mutants of Escherichia coli K-12. Pugsley, A.P., Reeves, P. J. Bacteriol. (1976) [Pubmed]
  12. The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase. Benach, J., Lee, I., Edstrom, W., Kuzin, A.P., Chiang, Y., Acton, T.B., Montelione, G.T., Hunt, J.F. J. Biol. Chem. (2003) [Pubmed]
  13. Hydroaromatic equilibration during biosynthesis of shikimic acid. Knop, D.R., Draths, K.M., Chandran, S.S., Barker, J.L., von Daeniken, R., Weber, W., Frost, J.W. J. Am. Chem. Soc. (2001) [Pubmed]
  14. Cloning and expression of functional shikimate dehydrogenase (EC from Mycobacterium tuberculosis H37Rv. Magalhães, M.L., Pereira, C.P., Basso, L.A., Santos, D.S. Protein Expr. Purif. (2002) [Pubmed]
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