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Gene Review

TGM5  -  transglutaminase 5

Homo sapiens

Synonyms: PSS2, Protein-glutamine gamma-glutamyltransferase 5, TG(X), TGASE5, TGASEX, ...
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Disease relevance of TGM5


High impact information on TGM5


Biological context of TGM5

  • Overexpressed transglutaminase 5 triggers cell death [7].
  • In addition to the previously described isoforms, full-length TGase 5 and Delta3 (deletion of exon 3), we identified two new splicing variants, Delta11 and Delta3Delta11 (deletion of exons 11 or 3, 11) [6].

Anatomical context of TGM5


Associations of TGM5 with chemical compounds

  • Chronic peroral administration of the antibiotic lincomycin to TGX rats in an attempt to suppress the enteric flora markedly decreased serum MMA levels [3].
  • The concentrations of MMA, MCA, and cystathionine were increased in kidney, liver, and spinal cord (SC) of TGX rats at 10 months [3].

Co-localisations of TGM5


Other interactions of TGM5


Analytical, diagnostic and therapeutic context of TGM5


  1. Expression of transglutaminase 5 in normal and pathologic human epidermis. Candi, E., Oddi, S., Paradisi, A., Terrinoni, A., Ranalli, M., Teofoli, P., Citro, G., Scarpato, S., Puddu, P., Melino, G. J. Invest. Dermatol. (2002) [Pubmed]
  2. Further evidence for the involvement of epidermal growth factor in the signaling pathway of vitamin B12 (cobalamin) in the rat central nervous system. Scalabrino, G., Tredici, G., Buccellato, F.R., Manfridi, A. J. Neuropathol. Exp. Neurol. (2000) [Pubmed]
  3. Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord. Scalabrino, G., Buccellato, F.R., Tredici, G., Morabito, A., Lorenzini, E.C., Allen, R.H., Lindenbaum, J. Exp. Neurol. (1997) [Pubmed]
  4. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Cassidy, A.J., van Steensel, M.A., Steijlen, P.M., van Geel, M., van der Velden, J., Morley, S.M., Terrinoni, A., Melino, G., Candi, E., McLean, W.H. Am. J. Hum. Genet. (2005) [Pubmed]
  5. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. Grenard, P., Bates, M.K., Aeschlimann, D. J. Biol. Chem. (2001) [Pubmed]
  6. Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro. Candi, E., Oddi, S., Terrinoni, A., Paradisi, A., Ranalli, M., Finazzi-Agró, A., Melino, G. J. Biol. Chem. (2001) [Pubmed]
  7. Overexpressed transglutaminase 5 triggers cell death. Cadot, B., Rufini, A., Pietroni, V., Ramadan, S., Guerrieri, P., Melino, G., Candi, E. Amino Acids (2004) [Pubmed]
  8. Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription-polymerase chain reaction with degenerate primers. Aeschlimann, D., Koeller, M.K., Allen-Hoffmann, B.L., Mosher, D.F. J. Biol. Chem. (1998) [Pubmed]
  9. Transglutaminase 5 expression in human hair follicle. Thibaut, S., Candi, E., Pietroni, V., Melino, G., Schmidt, R., Bernard, B.A. J. Invest. Dermatol. (2005) [Pubmed]
  10. Transglutaminase 5 is acetylated at the N-terminal end. Rufini, A., Vilbois, F., Paradisi, A., Oddi, S., Tartaglione, R., Leta, A., Bagetta, G., Guerrieri, P., Finazzi-Agro', A., Melino, G., Candi, E. Amino Acids (2004) [Pubmed]
  11. Subacute combined degeneration in totally gastrectomized rats: an ultrastructural study. Tredici, G., Buccellato, F.R., Cavaletti, G., Scalabrino, G. J. Submicrosc. Cytol. Pathol. (1998) [Pubmed]
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